KEGG   PATHWAY: mrv04217
Entry
mrv04217                    Pathway                                
Name
Necroptosis - Mauremys reevesii (Reeves's turtle)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
mrv04217  Necroptosis
mrv04217

Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120392459  TNF; tumor necrosis factor isoform X1 [KO:K03156]
120400408  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120384429  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120392446  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120392485  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120386646  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120402445  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
120396472  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
120371556  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
120372466  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
120397349  sharpin [KO:K10630] [EC:2.3.2.31]
120380894  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
120380881  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
120384287  uncharacterized protein LOC120384287 [KO:K17595]
120384596  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
120381282  SPATA2; spermatogenesis-associated protein 2 isoform X1 [KO:K17595]
120384494  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
120395122  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
120379753  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
120398869  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
120402879  FADD; FAS-associated death domain protein [KO:K02373]
120374759  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
120374760  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
120374824  CFLAR; LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
120381149  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
120395781  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
120396927  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
120405867  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
120368697  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
120369938  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
120372510  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
120406042  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
120406375  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
120381105  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
120406422  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
120370470  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120368580  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
120397042  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120370991  glutamate dehydrogenase, mitochondrial-like isoform X1 [KO:K00261] [EC:1.4.1.3]
120409124  GLUD1; glutamate dehydrogenase 1, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
120370624  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
120386907  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
120381821  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
120403273  PYGL; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
120369030  PYGM; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
120400963  PYGB; glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
120405833  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120368657  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120369865  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120384207  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
120384523  ferritin heavy chain A-like isoform X1 [KO:K00522] [EC:1.16.3.1]
120384524  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
120384527  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
120384539  ferritin heavy chain A-like isoform X1 [KO:K00522] [EC:1.16.3.1]
120384541  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
120384542  ferritin heavy chain A [KO:K00522] [EC:1.16.3.1]
120384543  ferritin heavy chain B-like isoform X1 [KO:K00522] [EC:1.16.3.1]
120384546  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
120404773  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
120388374  FTL; ferritin light chain [KO:K00522] [EC:1.16.3.1]
120392593  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120403377  PLA2G4B; LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
120384955  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120404423  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
120404471  LOW QUALITY PROTEIN: cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404486  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404503  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404532  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120404546  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
120405295  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
120380092  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380093  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380100  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380338  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120380930  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
120370232  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
120369426  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
120400983  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
120388744  CAPN12; calpain-12 isoform X1 [KO:K03853] [EC:3.4.22.53]
120400953  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
120395263  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
120384303  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
120388886  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120368662  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
120403840  NACHT, LRR and PYD domains-containing protein 3-like [KO:K12800]
120403842  NACHT, LRR and PYD domains-containing protein 3-like isoform X1 [KO:K12800]
120403845  NACHT, LRR and PYD domains-containing protein 3-like [KO:K12800]
120403206  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
120403207  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
120403214  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
120395022  caspase a-like [KO:K12799]
120395026  uncharacterized protein LOC120395026 [KO:K12799]
120395027  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
120404080  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
120387352  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
120397289  interleukin-1 beta-like [KO:K04519]
120399668  interleukin-1 beta-like [KO:K04519]
120393189  charged multivesicular body protein 2a [KO:K12191]
120394314  charged multivesicular body protein 2a [KO:K12191]
120395572  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
120380651  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
120396408  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
120383791  CHMP6; charged multivesicular body protein 6 [KO:K12195]
120384841  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
120399026  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
120372411  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
120384554  CHMP1A; charged multivesicular body protein 1a isoform X1 [KO:K12197]
120398762  CHMP5; charged multivesicular body protein 5 isoform X1 [KO:K12198]
120399336  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
120373012  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
120404875  HMGB1; high mobility group protein B1 isoform X1 [KO:K10802]
120372443  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
120397671  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
120403085  tumor necrosis factor receptor superfamily member 6-like [KO:K04722]
120370739  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120368627  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120407278  interferon beta-2-like [KO:K05414]
120407284  interferon beta-like [KO:K05414]
120407285  interferon beta-like [KO:K05414]
120407286  interferon beta-like [KO:K05414]
120407287  interferon epsilon-like [KO:K05414]
120407288  interferon beta-like [KO:K05414]
120407289  interferon beta-like [KO:K05414]
120407291  interferon beta-like [KO:K05414]
120407292  interferon beta-like [KO:K05414]
120407293  interferon epsilon-like [KO:K05414]
120407294  interferon beta-like [KO:K05414]
120407295  interferon beta-like [KO:K05414]
120407296  interferon kappa-like [KO:K05414]
120407297  interferon epsilon-like [KO:K05414]
120407300  interferon beta-like [KO:K05414]
120407302  interferon beta-like [KO:K05414]
120407541  interferon beta-like [KO:K05414]
120407717  interferon beta-like [KO:K05414]
120408182  interferon epsilon-like [KO:K05414]
120387499  IFNG; interferon gamma [KO:K04687]
120406639  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
120395610  interferon alpha/beta receptor 2-like [KO:K05131]
120379609  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
120400602  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
120398127  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
120369825  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120407999  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
120391643  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
120390943  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
120374631  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
120391254  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
120392259  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
120374670  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
120392110  signal transducer and activator of transcription 5B [KO:K11224]
120392261  signal transducer and activator of transcription 5B-like [KO:K11224]
120391151  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
120379815  IRF9; interferon regulatory factor 9 [KO:K04693]
120401970  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
120386592  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
120407821  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
120391899  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
120407044  TLR3; toll-like receptor 3 [KO:K05401]
120380931  ZBP1; Z-DNA-binding protein 1 [KO:K12965]
120390404  USP21; ubiquitin carboxyl-terminal hydrolase 21 isoform X1 [KO:K21634] [EC:3.4.19.12]
120370131  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
120404508  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
120400383  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
120401872  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
120401815  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
120408780  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
120388365  apoptosis regulator BAX-like isoform X1 [KO:K02159]
120388370  apoptosis regulator BAX-like isoform X1 [KO:K02159]
120371667  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
120403373  late histone H2A.1-like [KO:K11251]
120395647  histone H2A-beta, sperm-like [KO:K11251]
120395695  late histone H2A.2.2-like [KO:K11251]
120374059  histone H2A.J [KO:K11251]
120374068  histone H2A.J [KO:K11251]
120395746  histone H2A-beta, sperm-like [KO:K11251]
120395747  late histone H2A.2.2-like [KO:K11251]
120374077  histone H2A.J [KO:K11251]
120374087  histone H2A type 2-C [KO:K11251]
120374089  histone H2A type 2-C [KO:K11251]
120374094  histone H2A type 2-C [KO:K11251]
120374213  histone H2A type 2-C-like [KO:K11251]
120397136  histone H2A-like [KO:K11251]
120375699  histone H2AX [KO:K11251]
120397727  histone H2A.V isoform X1 [KO:K11251]
120407063  histone H2A.Z isoform X1 [KO:K11251]
120388622  histone H2A.J-like [KO:K11251]
120388702  histone H2A.J-like [KO:K11251]
120388703  histone H2A type 2-C-like [KO:K11251]
120388956  histone H2A.J-like [KO:K11251]
120409086  histone H2A type 2-B [KO:K11251]
120409181  core histone macro-H2A.2 isoform X1 [KO:K11251]
120369952  core histone macro-H2A.1 isoform X1 [KO:K11251]
120399014  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
120368942  peptidyl-prolyl cis-trans isomerase A-like [KO:K03767] [EC:5.2.1.8]
120398465  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
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pathway
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mrv04210  Apoptosis
KO pathway
ko04217   
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