KEGG   PATHWAY: mun00230
Entry
mun00230                    Pathway                                
Name
Purine metabolism - Meriones unguiculatus (Mongolian gerbil)
Class
Metabolism; Nucleotide metabolism
Pathway map
mun00230  Purine metabolism
mun00230

Module
mun_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mun00230]
mun_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mun00230]
mun_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mun00230]
mun_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mun00230]
mun_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mun00230]
mun_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mun00230]
mun_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mun00230]
Other DBs
GO: 0006163 0042278
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110541407  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
110552777  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
110560543  Nudt5; ADP-sugar pyrophosphatase isoform X2 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
110540378  Pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
110554834  Pgm2; phosphopentomutase isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
110539776  Prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
110566486  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
110558645  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
110554639  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
110565015  Ppat; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
110541947  Gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
110551719  Pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
110565016  Paics; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
110550440  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
110557289  Atic; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
110545196  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
110547737  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X2 [KO:K01081] [EC:3.1.3.5]
110549948  Nt5c1a; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
110549991  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
110542216  Nt5c1b; cytosolic 5'-nucleotidase 1B isoform X5 [KO:K01081] [EC:3.1.3.5]
110556648  Nt5c2; cytosolic purine 5'-nucleotidase isoform X5 [KO:K01081] [EC:3.1.3.5]
110558864  trifunctional nucleotide phosphoesterase protein YfkN-like [KO:K01081] [EC:3.1.3.5]
110558759  Nt5e; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
110549710  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
110561841  Lacc1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
110563135  Hprt1; hypoxanthine-guanine phosphoribosyltransferase isoform X2 [KO:K00760] [EC:2.4.2.8]
110562959  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X3 [KO:K00088] [EC:1.1.1.205]
110565350  Impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
110548666  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
110548690  Nme3; nucleoside diphosphate kinase 3 isoform X2 [KO:K00940] [EC:2.7.4.6]
110549936  Nme7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
110552059  Nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
110552060  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
132648361  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
110564519  Nme6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
110555437  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
110546327  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
110557023  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
110566250  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
110550202  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
110554941  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
110546974  Entpd5; nucleoside diphosphate phosphatase ENTPD5 [KO:K01511] [EC:3.6.1.6]
110565692  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
110552037  U8 snoRNA-decapping enzyme isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
110541621  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
110558618  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
110557067  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
110547105  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
110566507  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
110556516  Gmpr2; GMP reductase 2 isoform X2 [KO:K00364] [EC:1.7.1.7]
110556605  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
110564923  Gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
110552177  Guk1; guanylate kinase isoform X2 [KO:K00942] [EC:2.7.4.8]
110541570  Rrm1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
110556931  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
110564262  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
110561581  Hddc2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
110551248  Dguok; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
110540094  Dck; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
110553371  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
110560777  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
110555169  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110550962  Adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
110555185  Adcy3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
110556521  Adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
110547229  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110559444  Adcy6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
110560723  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110561696  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110545944  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110561746  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
110566017  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
110550450  Gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
110566519  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
110566016  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
110552758  Gucy2c; guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
110560570  guanylate cyclase D [KO:K12321] [EC:4.6.1.2]
110551701  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
110542656  Gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
110560937  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
110554242  Npr1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
110561887  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
110554671  Pde1c; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
110562902  Pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3 [KO:K13755] [EC:3.1.4.17]
110557591  Pde1b; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
110550791  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
110565496  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
110549429  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
110563856  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
110546700  Pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
110553620  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
110558284  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
110561637  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
110548796  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
110552747  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
110553310  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
110559759  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
110564711  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
110552493  Adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
110558969  Adss1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
110545516  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
110541129  Ampd3; AMP deaminase 3 isoform X3 [KO:K01490] [EC:3.5.4.6]
110558451  Ampd1; LOW QUALITY PROTEIN: AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
110548873  Adk; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
110548228  Ada; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
110548693  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
110555924  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
110546290  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
110559042  Ak4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
110563248  Ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
110556064  Ak5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
110565224  Ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
110539854  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
110547008  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
110557033  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
110555255  Ntpcr; cancer-related nucleoside-triphosphatase isoform X3 [KO:K06928] [EC:3.6.1.15]
110553647  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
110539863  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
110562135  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7 [KO:K13293] [EC:3.1.4.53]
110555768  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
110549146  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X4 [KO:K13293] [EC:3.1.4.53]
110562364  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
110554632  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
110562183  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
110540078  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
110540896  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
110565012  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
110552105  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
110562926  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
110566091  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
110555015  uricase [KO:K00365] [EC:1.7.3.3]
110553896  5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
110558584  Allc; probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mun00030  Pentose phosphate pathway
mun00220  Arginine biosynthesis
mun00250  Alanine, aspartate and glutamate metabolism
mun00260  Glycine, serine and threonine metabolism
mun00340  Histidine metabolism
mun00630  Glyoxylate and dicarboxylate metabolism
mun00730  Thiamine metabolism
mun00740  Riboflavin metabolism
mun00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system