KEGG   PATHWAY: npd04621
Entry
npd04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Nothoprocta perdicaria (Chilean tinamou)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
npd04621  NOD-like receptor signaling pathway
npd04621

Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112952613  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
112960327  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
112950571  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
112948431  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112953853  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112958044  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112957315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112950535  IL1B; interleukin-1 beta [KO:K04519]
112948749  IL18; interleukin-18 isoform X1 [KO:K05482]
112942428  IL6; interleukin-6 [KO:K05405]
112950070  interleukin-8-like [KO:K10030]
112950072  interleukin-8-like [KO:K10030]
112950088  interleukin-8-like [KO:K10030]
112956740  C-C motif chemokine 5-like [KO:K12499]
112951549  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
112948961  antimicrobial peptide THP2 [KO:K21100]
112946540  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112947715  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112951648  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112954154  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112954523  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112948967  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112956827  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112959724  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112959727  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112959234  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112959267  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112943557  JUN; transcription factor AP-1 [KO:K04448]
112949225  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
112945119  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
112958909  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
112947476  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
112955779  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
112949898  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
112950033  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X1 [KO:K10435]
112956471  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
112952023  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
112943349  SUGT1; protein SGT1 homolog [KO:K12795]
112944519  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
112945322  ERBIN; erbin isoform X1 [KO:K12796]
112943708  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112956027  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112955136  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112943501  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112955855  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
112954930  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
112955527  skin secretory protein xP2-like [KO:K12648]
112955397  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112958829  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112944634  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
112958645  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
112943579  IRF7; interferon regulatory factor 7 [KO:K09447]
112956287  interferon beta-like [KO:K05414]
112951392  interferon kappa-like [KO:K05414]
112948733  NLRX1; NLR family member X1 [KO:K12653]
112950091  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
112951100  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
112957238  ANTXRL; anthrax toxin receptor-like [KO:K20909]
112956725  caspase-1-like [KO:K01370] [EC:3.4.22.36]
112943408  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
112949757  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112948531  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
112959012  PANX1; pannexin-1 [KO:K03443]
112944863  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
112952774  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
112954601  transient receptor potential cation channel subfamily V member 2-like [KO:K04971]
112960119  CASR; extracellular calcium-sensing receptor [KO:K04612]
112954207  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
112952062  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
112958919  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112958952  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112944112  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112950663  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112959174  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112952833  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
112951455  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
112953854  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
112952227  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
112950418  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
112956646  DHX33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
112952572  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
112959575  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
112947649  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112948151  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
112953322  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
112954155  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
112949947  cytochrome b-245 light chain [KO:K08009]
112950655  TXNIP; thioredoxin-interacting protein [KO:K20910]
112948527  thioredoxin [KO:K03671]
112958442  TXN2; thioredoxin, mitochondrial [KO:K03671]
112951226  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
112948665  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
112956927  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112956379  CARD8; caspase recruitment domain-containing protein 8 [KO:K12801]
112946732  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
112956289  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
112956309  caspase-8-like [KO:K04398] [EC:3.4.22.61]
112943547  FADD; FAS-associated death domain protein [KO:K02373]
112952061  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K20865]
112953052  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
112954148  TP53BP1; TP53-binding protein 1 [KO:K20915]
112953407  RHOA; transforming protein RhoA [KO:K04513]
112946116  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
112954600  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
112953617  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
112953615  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112945520  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112957333  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
112954430  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112955622  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
112955980  TLR4; toll-like receptor 4 [KO:K10160]
112943864  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112958106  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112956803  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112944344  TMEM173; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
npd04010  MAPK signaling pathway
npd04140  Autophagy - animal
npd04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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