Entry Name NOD-like receptor signaling pathway
Description Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ko04621 NOD-like receptor signaling pathway
Ortholog table Drug Orthology K08727 nucleotide-binding oligomerization domain-containing protein 1
K08846 receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1 ]
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K02581 NF-kappa-B inhibitor beta
K04734 NF-kappa-B inhibitor alpha
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K03156 tumor necrosis factor superfamily, member 2
K05505 C-X-C motif chemokine 1/2/3
K13916 cathelicidin antimicrobial peptide
K10165 nucleotide-binding oligomerization domain-containing protein 2
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 transcription factor AP-1
K17890 autophagy-related protein 16-1
K08339 autophagy-related protein 5
K08336 ubiquitin-like protein ATG12
K08341 GABA(A) receptor-associated protein
K10435 microtubule-associated protein 1 light chain
K12795 suppressor of G2 allele of SKP1
K20894 shank-associated RH domain-interacting protein
K10630 RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31 ]
K12797 caspase recruitment domain-containing protein 6
K12792 thyroid receptor-interacting protein 6
K12796 erbb2-interacting protein
K16060 baculoviral IAP repeat-containing protein 2/3
K09849 TNF receptor-associated factor 5
K12794 caspase recruitment domain-containing protein 9
K12648 mitochondrial antiviral-signaling protein
K03174 TNF receptor-associated factor 3
K07211 inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K12650 TRAF family member-associated NF-kappa-B activator
K05411 interferon regulatory factor 3
K09447 interferon regulatory factor 7
K12798 NACHT, LRR and PYD domains-containing protein 1
K12799 apoptosis-associated speck-like protein containing a CARD
K02161 apoptosis regulator Bcl-2
K04570 Bcl-2-like 1 (apoptosis regulator Bcl-X)
K12800 NACHT, LRR and PYD domains-containing protein 3
K04977 transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13 ]
K04982 transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1 ]
K04971 transient receptor potential cation channel subfamily V member 2
K04612 calcium-sensing receptor
K04622 G protein-coupled receptor family C group 6 member A
K04958 inositol 1,4,5-triphosphate receptor type 1
K04959 inositol 1,4,5-triphosphate receptor type 2
K04960 inositol 1,4,5-triphosphate receptor type 3
K05862 voltage-dependent anion channel protein 1
K15040 voltage-dependent anion channel protein 2
K15041 voltage-dependent anion channel protein 3
K20858 calcium uniporter protein, mitochondrial
K21356 mitofusin 1 [EC:3.6.5.-]
K06030 mitofusin 2 [EC:3.6.5.-]
K02861 receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K08847 receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1 ]
K21421 NADPH oxidase 2 [EC:1.-.-.-]
K08009 cytochrome b-245, alpha polypeptide
K20910 thioredoxin-interacting protein
K11864 BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
K04079 molecular chaperone HtpG
K12801 caspase recruitment domain-containing protein 8
K15838 G-protein signaling modulator 3
K14139 immunity-related GTPase family M protein [EC:3.6.5.-]
K12802 pyrin domain-containing protein 1
K20911 pyrin domain-containing protein 2
K12804 proline-serine-threonine phosphatase interacting protein 1
K02373 FAS-associated death domain protein
K04741 caspase 12 [EC:3.4.22.-]
K12806 caspase recruitment domain-containing protein 16/17/18
K20863 NACHT, LRR and PYD domains-containing protein 6
K20864 NACHT, LRR and PYD domains-containing protein 7
K20865 NACHT, LRR and PYD domains-containing protein 12
K12807 baculoviral IAP repeat-containing protein 1
K12805 NLR family CARD domain-containing protein 4
K20897 guanylate-binding protein 2
K20898 guanylate-binding protein 5
K20914 gamma-interferon-inducible protein 16
K20915 tumor suppressor p53-binding protein 1
K20916 pyrin domain-only protein 3
K04513 Ras homolog gene family, member A
K20899 guanylate-binding protein 1/3/4/7
K11220 signal transducer and activator of transcription 1
K11221 signal transducer and activator of transcription 2
K04693 interferon regulatory factor 9
K05842 toll-like receptor adapter molecule 1
K04729 myeloid differentiation primary response protein MyD88
K12654 stimulator of interferon genes protein
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Vandenabeele P, Bertrand MJ
Title The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
Journal Reference Authors Strober W, Murray PJ, Kitani A, Watanabe T
Title Signalling pathways and molecular interactions of NOD1 and NOD2.
Journal Reference Authors Estornes Y, Bertrand MJ
Title IAPs, regulators of innate immunity and inflammation.
Journal Reference Authors Jakopin Z
Title Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
Journal Reference Authors Caruso R, Warner N, Inohara N, Nunez G
Title NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Journal Reference Authors Murray PJ
Title Beyond peptidoglycan for Nod2.
Journal Reference Authors Lecat A, Piette J, Legrand-Poels S
Title The protein Nod2: an innate receptor more complex than previously assumed.
Journal Reference Authors Man SM, Kanneganti TD
Title Converging roles of caspases in inflammasome activation, cell death and innate immunity.
Journal Reference Authors Broz P, Dixit VM
Title Inflammasomes: mechanism of assembly, regulation and signalling.
Journal Reference Authors Man SM, Kanneganti TD
Title Regulation of inflammasome activation.
Journal Reference Authors Jo EK, Kim JK, Shin DM, Sasakawa C
Title Molecular mechanisms regulating NLRP3 inflammasome activation.
Journal Reference Authors Broz P, Monack DM
Title Newly described pattern recognition receptors team up against intracellular pathogens.
Journal Reference Authors Rathinam VA, Vanaja SK, Fitzgerald KA
Title Regulation of inflammasome signaling.
Journal Reference Authors Sutterwala FS, Haasken S, Cassel SL
Title Mechanism of NLRP3 inflammasome activation.
Journal Reference Authors Latz E, Xiao TS, Stutz A
Title Activation and regulation of the inflammasomes.
Journal Reference Authors Blander JM
Title A long-awaited merger of the pathways mediating host defence and programmed cell death.
Journal Reference Authors von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
Title Recognition of bacteria by inflammasomes.
Journal Reference Authors Abais JM, Xia M, Zhang Y, Boini KM, Li PL
Title Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
Journal Reference Authors Storek KM, Monack DM
Title Bacterial recognition pathways that lead to inflammasome activation.
Journal Reference Authors Hu H, Sun SC
Title Ubiquitin signaling in immune responses.
Journal Reference Authors Guo H, Callaway JB, Ting JP
Title Inflammasomes: mechanism of action, role in disease, and therapeutics.
Journal Reference Authors Man SM, Kanneganti TD
Title Gasdermin D: the long-awaited executioner of pyroptosis.
Journal Reference Authors Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Title TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Journal Reference Authors Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
Title IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
Journal Reference Authors Heilig R, Broz P
Title Function and mechanism of the pyrin inflammasome.
Journal Reference Authors Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
Title RNase L activates the NLRP3 inflammasome during viral infections.
Journal Related ko04064 NF-kappa B signaling pathway
ko04620 Toll-like receptor signaling pathway
LinkDB All DBs
