Entry Name NOD-like receptor signaling pathway
Description Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ko04621 NOD-like receptor signaling pathway
Drug Orthology K02161 BCL2; apoptosis regulator Bcl-2
K02373 FADD; FAS-associated death domain protein
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02581 NFKBIB; NF-kappa-B inhibitor beta
K02861 RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1 ]
K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K03174 TRAF3; TNF receptor-associated factor 3
K04079 HSP90A, htpG; molecular chaperone HtpG
K04403 MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404 MAP3K7IP2, TAB2; TAK1-binding protein 2
K04427 MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04448 JUN; transcription factor AP-1
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04513 RHOA; Ras homolog gene family, member A
K04519 IL1B; interleukin 1 beta
K04570 BCL2L1, bcl-xL; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K04612 CASR; calcium-sensing receptor
K04622 GPRC6A; G protein-coupled receptor family C group 6 member A
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1 ]
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K04741 CASP12; caspase 12 [EC:3.4.22.-]
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K04971 TRPV2; transient receptor potential cation channel subfamily V member 2
K04977 TRPM2; transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13 ]
K04982 TRPM7, CHAK1; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1 ]
K05130 IFNAR1; interferon receptor 1
K05131 IFNAR2; interferon receptor 2
K05220 P2RX7; P2X purinoceptor 7
K05411 IRF3; interferon regulatory factor 3
K05482 IL18, IL1F4; interleukin 18
K05505 CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3
K05842 TRIF; toll-like receptor adapter molecule 1
K05862 VDAC1; voltage-dependent anion channel protein 1
K06030 MFN2, FZO1; mitofusin 2 [EC:3.6.5.-]
K06630 YWHAE; 14-3-3 protein epsilon
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K08009 CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
K08336 ATG12; ubiquitin-like protein ATG12
K08339 ATG5; autophagy-related protein 5
K08341 GABARAP, ATG8, LC3; GABA(A) receptor-associated protein
K08598 yopJ; YopJ protease family
K08727 NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
K08846 RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1 ]
K08847 RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1 ]
K09447 IRF7; interferon regulatory factor 7
K09849 TRAF5; TNF receptor-associated factor 5
K10030 IL8, CXCL8; interleukin 8
K10160 TLR4, CD284; toll-like receptor 4
K10165 NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
K10435 MAP1LC; microtubule-associated protein 1 light chain
K10630 RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31 ]
K11030 pagA; protective antigen
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K11859 TNFAIP3, A20, OTUD7C; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12 ]
K11864 BRCC3, BRCC36; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
K12499 CCL5; C-C motif chemokine 5
K12648 MAVS, IPS1; mitochondrial antiviral-signaling protein
K12650 TANK; TRAF family member-associated NF-kappa-B activator
K12653 NLRX1; NLR family member X1
K12654 STING1, TMEM173, MITA; stimulator of interferon genes protein
K12792 TRIP6; thyroid receptor-interacting protein 6
K12793 MAP3K7IP3, TAB3; TAK1-binding protein 3
K12794 CARD9; caspase recruitment domain-containing protein 9
K12795 SUGT1, SGT1; suppressor of G2 allele of SKP1
K12796 ERBIN, ERBB2IP; erbb2-interacting protein
K12797 CARD6; caspase recruitment domain-containing protein 6
K12798 NLRP1, CARD7; NACHT, LRR and PYD domains-containing protein 1
K12799 PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
K12800 NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
K12801 CARD8, CARDINAL; caspase recruitment domain-containing protein 8
K12802 PYDC1; pyrin domain-containing protein 1
K12804 PSTPIP1; proline-serine-threonine phosphatase interacting protein 1
K12805 NLRC4, CARD12; NLR family CARD domain-containing protein 4
K12806 CARD16_17_18; caspase recruitment domain-containing protein 16/17/18
K12807 NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
K12966 AIM2; absent in melanoma 2
K13916 CAMP, LL37; cathelicidin antimicrobial peptide
K14139 IRGM, LRG47; immunity-related GTPase family M protein [EC:3.6.5.-]
K14624 CCL2, MCP1; C-C motif chemokine 2
K15040 VDAC2; voltage-dependent anion channel protein 2
K15041 VDAC3; voltage-dependent anion channel protein 3
K15838 GPSM3, AGS4; G-protein signaling modulator 3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K17890 ATG16L1; autophagy-related protein 16-1
K20858 MCU; calcium uniporter protein, mitochondrial
K20863 NLRP6, NALP6; NACHT, LRR and PYD domains-containing protein 6
K20864 NLRP7, NALP7; NACHT, LRR and PYD domains-containing protein 7
K20865 NLRP12; NACHT, LRR and PYD domains-containing protein 12
K20894 SHARPIN; shank-associated RH domain-interacting protein
K20897 GBP2; guanylate-binding protein 2
K20898 GBP5; guanylate-binding protein 5
K20899 GBP1_3_4_7; guanylate-binding protein 1/3/4/7
K20909 ANTXR; anthrax toxin receptor
K20910 TXNIP; thioredoxin-interacting protein
K20911 PYDC2, POP2; pyrin domain-containing protein 2
K20914 IFI16; gamma-interferon-inducible protein 16
K20915 TP53BP1, P202; tumor suppressor p53-binding protein 1
K20916 POP3; pyrin domain-only protein 3
K21356 MFN1; mitofusin 1 [EC:3.6.5.-]
K21421 NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
K23126 DEFB103; beta-defensin 103
K23691 PKN2; serine/threonine-protein kinase N2
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Vandenabeele P, Bertrand MJ
Title The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
Journal Reference Authors Strober W, Murray PJ, Kitani A, Watanabe T
Title Signalling pathways and molecular interactions of NOD1 and NOD2.
Journal Reference Authors Estornes Y, Bertrand MJ
Title IAPs, regulators of innate immunity and inflammation.
Journal Reference Authors Jakopin Z
Title Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
Journal Reference Authors Caruso R, Warner N, Inohara N, Nunez G
Title NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Journal Reference Authors Murray PJ
Title Beyond peptidoglycan for Nod2.
Journal Reference Authors Lecat A, Piette J, Legrand-Poels S
Title The protein Nod2: an innate receptor more complex than previously assumed.
Journal Reference Authors Man SM, Kanneganti TD
Title Converging roles of caspases in inflammasome activation, cell death and innate immunity.
Journal Reference Authors Broz P, Dixit VM
Title Inflammasomes: mechanism of assembly, regulation and signalling.
Journal Reference Authors Man SM, Kanneganti TD
Title Regulation of inflammasome activation.
Journal Reference Authors Jo EK, Kim JK, Shin DM, Sasakawa C
Title Molecular mechanisms regulating NLRP3 inflammasome activation.
Journal Reference Authors Broz P, Monack DM
Title Newly described pattern recognition receptors team up against intracellular pathogens.
Journal Reference Authors Rathinam VA, Vanaja SK, Fitzgerald KA
Title Regulation of inflammasome signaling.
Journal Reference Authors Sutterwala FS, Haasken S, Cassel SL
Title Mechanism of NLRP3 inflammasome activation.
Journal Reference Authors Latz E, Xiao TS, Stutz A
Title Activation and regulation of the inflammasomes.
Journal Reference Authors Blander JM
Title A long-awaited merger of the pathways mediating host defence and programmed cell death.
Journal Reference Authors von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
Title Recognition of bacteria by inflammasomes.
Journal Reference Authors Abais JM, Xia M, Zhang Y, Boini KM, Li PL
Title Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
Journal Reference Authors Storek KM, Monack DM
Title Bacterial recognition pathways that lead to inflammasome activation.
Journal Reference Authors Hu H, Sun SC
Title Ubiquitin signaling in immune responses.
Journal Reference Authors Guo H, Callaway JB, Ting JP
Title Inflammasomes: mechanism of action, role in disease, and therapeutics.
Journal Reference Authors Man SM, Kanneganti TD
Title Gasdermin D: the long-awaited executioner of pyroptosis.
Journal Reference Authors Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
Title TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Journal Reference Authors Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
Title IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
Journal Reference Authors Heilig R, Broz P
Title Function and mechanism of the pyrin inflammasome.
Journal Reference Authors Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
Title RNase L activates the NLRP3 inflammasome during viral infections.
Journal Related ko04064 NF-kappa B signaling pathway
ko04620 Toll-like receptor signaling pathway
