KEGG   PATHWAY: ocu04723
Entry
ocu04723                    Pathway                                
Name
Retrograde endocannabinoid signaling - Oryctolagus cuniculus (rabbit)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
ocu04723  Retrograde endocannabinoid signaling
ocu04723

Other DBs
GO: 0071926
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100338809  vesicular glutamate transporter 3 isoform X1 [KO:K12302]
100339044  vesicular glutamate transporter 1 [KO:K12302]
100349381  vesicular glutamate transporter 2 isoform X1 [KO:K12302]
100348217  glutamate receptor 1 isoform X1 [KO:K05197]
100357153  glutamate receptor 2 isoform X1 [KO:K05198]
100341980  glutamate receptor 3 isoform X2 [KO:K05199]
100338204  glutamate receptor 4 isoform X1 [KO:K05200]
100101555  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100357261  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100009585  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100356201  metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100340633  metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100340719  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100348672  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
100350395  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100341512  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
103347536  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100009505  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100356806  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100008939  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100352578  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [KO:K13985] [EC:3.1.4.54]
100037720  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100037719  PRKCB; protein kinase C beta type isoform I [KO:K19662] [EC:2.7.11.13]
100009102  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100342661  diacylglycerol lipase-alpha isoform X1 [KO:K13806] [EC:3.1.1.116]
100339619  diacylglycerol lipase-beta isoform X1 [KO:K13806] [EC:3.1.1.116]
100009248  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100355792  monoacylglycerol lipase ABHD6 [KO:K13700] [EC:3.1.1.23]
100343219  fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
100339826  cannabinoid receptor 1 [KO:K04277]
100338391  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100359147  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100339066  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100342283  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
100337783  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
127489280  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100356799  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100346625  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
100338332  guanine nucleotide-binding protein subunit beta-4 isoform X2 [KO:K04538]
100008941  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100352954  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100348350  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X2 [KO:K04540]
103350926  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108178480  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
100355417  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108177128  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100342201  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
108176185  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
103350153  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
127489712  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100342450  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108178552  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
100009366  G protein-activated inward rectifier potassium channel 1 [KO:K04997]
100008865  G protein-activated inward rectifier potassium channel 2 [KO:K05000]
100345513  G protein-activated inward rectifier potassium channel 3 [KO:K05002]
100352473  G protein-activated inward rectifier potassium channel 4 [KO:K04999]
100009265  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
100008979  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100350614  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
103346035  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
100344161  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100341695  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103347035  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100009201  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100343958  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100346742  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100354934  adenylate cyclase type 6 isoform X8 [KO:K08046] [EC:4.6.1.1]
100357357  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100337882  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100340877  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100338398  monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
808226  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808230  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808221  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808225  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808222  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808224  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808223  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
127486372  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100358684  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X2 [KO:K03943] [EC:7.1.1.2]
103346740  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
100351141  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100356593  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X2 [KO:K03948]
100347823  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108175419  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
100348563  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100349288  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
100352718  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100347938  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100352330  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
100342678  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
100349320  acyl carrier protein, mitochondrial [KO:K03955]
100341993  acyl carrier protein, mitochondrial-like [KO:K03955]
100349642  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
100355529  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103346555  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103348994  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
127484881  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
100350704  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
100354603  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100345777  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100339082  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
100347288  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
127488114  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
100346817  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
100008594  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
127486440  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
127486401  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100339424  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100341941  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
100352168  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
100355349  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100344233  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
100342714  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100345307  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
127490235  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
127486867  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
103350693  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100347545  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100350638  vesicular inhibitory amino acid transporter [KO:K15015]
100345340  regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
100349107  gamma-aminobutyric acid receptor subunit alpha-3 isoform X3 [KO:K05175]
100340943  gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
100339882  gamma-aminobutyric acid receptor subunit alpha-4 isoform X1 [KO:K05175]
100356785  gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
100357047  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 precursor [KO:K05175]
100339376  gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
100341200  gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
100340127  gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
100356357  gamma-aminobutyric acid receptor subunit beta-2 isoform X2 [KO:K05181]
100356092  gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
100357302  gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
108178364  gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
100348213  gamma-aminobutyric acid receptor subunit delta isoform X1 [KO:K05184]
100349357  gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
100352807  gamma-aminobutyric acid receptor subunit theta isoform X1 [KO:K05192]
100339970  gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
100341013  gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
100341270  gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
100341192  gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
ocu00190  Oxidative phosphorylation
ocu04020  Calcium signaling pathway
ocu04721  Synaptic vesicle cycle
ocu04724  Glutamatergic synapse
ocu04727  GABAergic synapse
KO pathway
ko04723   
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