KEGG   PATHWAY: oki04115
Entry
oki04115                    Pathway                                
Name
p53 signaling pathway - Oncorhynchus kisutch (coho salmon)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
oki04115  p53 signaling pathway
oki04115

Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109909170  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
109876183  serine/threonine-protein kinase Chk2-like [KO:K06641] [EC:2.7.11.1]
109895648  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
109884023  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
109881514  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
109902873  gorab; RAB6-interacting golgin [KO:K19748]
109885927  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
109885926  E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
109891067  mdm4; protein Mdm4 isoform X1 [KO:K10127]
109897084  cellular tumor antigen p53-like isoform X1 [KO:K04451]
109906265  cellular tumor antigen p53-like [KO:K04451]
109873031  tp53; cellular tumor antigen p53 isoform X2 [KO:K04451]
109909512  ppp1r13l; relA-associated inhibitor [KO:K27356]
109896771  cyclin-dependent kinase inhibitor 1B isoform X2 [KO:K06625]
109891106  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
109879117  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
109895960  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
109889644  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
109895467  G1/S-specific cyclin-D1 [KO:K04503]
109867514  G1/S-specific cyclin-D1-like [KO:K04503]
109885836  G1/S-specific cyclin-D1 [KO:K04503]
109889568  G1/S-specific cyclin-D2 isoform X2 [KO:K10151]
109897410  G1/S-specific cyclin-D2-like [KO:K10151]
109896687  G1/S-specific cyclin-D2-like [KO:K10151]
109864549  G1/S-specific cyclin-D2 [KO:K10151]
109883676  G1/S-specific cyclin-D2-like [KO:K10151]
109867280  G1/S-specific cyclin-D2 isoform X2 [KO:K10151]
109891102  G1/S-specific cyclin-D2-like [KO:K10152]
109882619  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
109894658  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
109907201  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
109904398  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
109893282  cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
109901970  G1/S-specific cyclin-E2 [KO:K06626]
109908176  G1/S-specific cyclin-E2 [KO:K06626]
109895481  G1/S-specific cyclin-E1 [KO:K06626]
109886072  G1/S-specific cyclin-E1 [KO:K06626]
109894563  cyclin-dependent kinase 2-like isoform X2 [KO:K02206] [EC:2.7.11.22]
109882628  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109868902  protein reprimo A [KO:K10128]
109902467  protein reprimo A-like [KO:K10128]
109867955  G2/mitotic-specific cyclin-B1 [KO:K05868]
109874313  G2/mitotic-specific cyclin-B1 [KO:K05868]
109895006  G2/mitotic-specific cyclin-B1 [KO:K05868]
109887808  G2/mitotic-specific cyclin-B2 [KO:K21770]
109905879  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
109895385  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
109890002  cyclin-dependent kinase 1-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109899760  cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109896151  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109889097  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
109868689  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109868714  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109898068  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109872257  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109902355  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109902765  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
109874104  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109874105  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109883147  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
109875313  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
109897761  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
109869671  zinc finger protein 385A-like isoform X1 [KO:K26543]
109890231  zinc finger protein 385A-like isoform X1 [KO:K26543]
109908593  zinc finger protein 385A-like [KO:K26543]
109895790  zinc finger protein 385A isoform X1 [KO:K26543]
109889950  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109899109  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
109883840  pidd1; LOW QUALITY PROTEIN: p53-induced death domain-containing protein 1 [KO:K10130]
109868307  tumor necrosis factor receptor superfamily member 10B [KO:K04722]
109872299  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
109873941  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
109896106  tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
109872357  caspase-8 [KO:K04398] [EC:3.4.22.61]
109870629  caspase-8 isoform X3 [KO:K04398] [EC:3.4.22.61]
109866944  caspase-8-like [KO:K04398] [EC:3.4.22.61]
109880007  caspase-8 isoform X2 [KO:K04398] [EC:3.4.22.61]
109867112  BH3-interacting domain death agonist [KO:K04726]
109893341  apoptosis regulator BAX-like isoform X2 [KO:K02159]
109893357  apoptosis regulator BAX isoform X1 [KO:K02159]
109895513  apoptosis regulator BAX-like [KO:K02159]
109885786  apoptosis regulator BAX-like isoform X1 [KO:K02159]
109893143  apoptosis regulator BAX isoform X1 [KO:K02159]
109897545  apoptosis regulator BAX-like isoform X1 [KO:K02159]
109894540  apoptosis regulatory protein Siva isoform X1 [KO:K22744]
109904001  apoptosis regulatory protein Siva [KO:K22744]
109897764  bcl-2-like protein 1 [KO:K04570]
109869528  bcl-2-like protein 1 [KO:K04570]
109890954  bcl-2-like protein 1 [KO:K04570]
109907974  bcl-2-like protein 1 isoform X1 [KO:K04570]
109909828  apoptosis regulator Bcl-2-like [KO:K02161]
109899300  apoptosis regulator Bcl-2-like [KO:K02161]
109872384  apoptosis regulator Bcl-2-like [KO:K02161]
109874825  apoptosis regulator Bcl-2-like [KO:K02161]
109904320  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
109892717  etoposide-induced protein 2.4 homolog [KO:K10134]
109872777  etoposide-induced protein 2.4 homolog [KO:K10134]
109891461  protein shisa-5 isoform X1 [KO:K10135]
109880441  protein shisa-4 isoform X1 [KO:K10135]
109875865  p53 apoptosis effector related to PMP-22-like [KO:K10136]
109870106  p53 apoptosis effector related to PMP-22 [KO:K10136]
109897962  zinc finger matrin-type protein 3-like isoform X2 [KO:K10137]
109902988  zmat3; zinc finger matrin-type protein 3 isoform X2 [KO:K10137]
109889311  E3 ubiquitin-protein ligase Siah1 isoform X2 [KO:K04506] [EC:2.3.2.27]
109867486  E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
109890126  cytochrome c-like [KO:K08738]
109870995  cytochrome c [KO:K08738]
109908435  cytochrome c iso-1/iso-2-like [KO:K08738]
109866923  cytochrome c [KO:K08738]
109878550  apoptotic protease-activating factor 1-like isoform X1 [KO:K02084]
109882975  apoptotic protease-activating factor 1-like [KO:K02084]
109869567  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
109905000  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109901037  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109894209  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
109882220  caspase-3-like [KO:K02187] [EC:3.4.22.56]
109889859  aifm2; apoptosis-inducing factor 2 [KO:K22745]
116353052  insulin-like growth factor-binding protein 3 [KO:K10138]
109898102  insulin-like growth factor-binding protein 3 [KO:K10138]
109872345  insulin-like growth factor-binding protein 3 [KO:K10138]
109896659  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
109896674  insulin-like growth factor I isoform X1 [KO:K05459]
109896857  plasminogen activator inhibitor 1 [KO:K03982]
109880450  plasminogen activator inhibitor 1 [KO:K03982]
109901437  adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
109906949  adhesion G protein-coupled receptor B1-like [KO:K04596]
109903749  adhesion G protein-coupled receptor B1 [KO:K04596]
109888736  CD82 antigen [KO:K06509]
109886907  CD82 antigen-like [KO:K06509]
116361828  CD82 antigen-like [KO:K06509]
109877885  CD82 antigen-like [KO:K06509]
109881734  leukocyte antigen CD37 [KO:K06509]
109894521  thrombospondin-1-like [KO:K16857]
109878706  thrombospondin-1-like [KO:K16857]
109866447  thrombospondin-1 isoform X1 [KO:K16857]
109904020  thrombospondin-1 [KO:K16857]
109885077  ddb2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
109900601  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
109866461  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
109903300  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
109905173  sestrin-3 isoform X2 [KO:K10141]
109875672  sestrin-3-like [KO:K10141]
109892645  sestrin-3-like [KO:K10141]
109864759  sestrin-3-like isoform X1 [KO:K10141]
109901007  sestrin-1-like isoform X1 [KO:K10141]
109866278  sesn1; sestrin-1 isoform X1 [KO:K10141]
109907331  sestrin-2-like isoform X1 [KO:K20394]
109889949  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109870175  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109899723  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109865358  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109878903  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
109878161  metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
109869105  metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
109871927  cop1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
109874805  E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
109877000  RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
109895712  RING finger and CHY zinc finger domain-containing protein 1-like isoform X1 [KO:K10144] [EC:2.3.2.27]
109878332  cyclin-G1 isoform X1 [KO:K10145]
109879493  ccng1; cyclin-G1 [KO:K10145]
109875991  cyclin-G2 [KO:K10146]
109868291  cyclin-G2 [KO:K10146]
109877226  cyclin-G2 [KO:K10146]
109895721  cyclin-G2-like isoform X1 [KO:K10146]
109872804  protein phosphatase 1D isoform X1 [KO:K10147] [EC:3.1.3.16]
109880954  protein phosphatase 1D-like [KO:K10147] [EC:3.1.3.16]
109907899  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
oki04110  Cell cycle
oki04210  Apoptosis
oki04218  Cellular senescence
KO pathway
ko04115   
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