KEGG   PATHWAY: oki04110
Entry
oki04110                    Pathway                                
Name
Cell cycle - Oncorhynchus kisutch (coho salmon)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
oki04110  Cell cycle
oki04110

Other DBs
GO: 0000278
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109864404  [KO:K06624]
109864462  [KO:K09392]
109864549  [KO:K10151]
109864566  [KO:K08866] [EC:2.7.12.1]
109864859  [KO:K06627]
109864860  [KO:K13376]
109864917  [KO:K03868] [EC:2.3.2.32]
109864919  mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
109865201  [KO:K06629]
109865375  [KO:K25163]
109865398  [KO:K03353]
109865887  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
109866059  [KO:K02213]
109866256  [KO:K11268] [EC:2.3.1.-]
109866260  [KO:K11584]
109866411  [KO:K16197]
109866563  [KO:K02178] [EC:2.7.11.1]
109866626  [KO:K06067] [EC:3.5.1.98]
109866829  [KO:K06636]
109866855  [KO:K06632] [EC:2.7.11.1]
109867203  ddx11; ATP-dependent DNA helicase DDX11 isoform X2 [KO:K11273] [EC:5.6.2.7]
109867280  [KO:K10151]
109867294  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109867316  [KO:K16332]
109867393  [KO:K11479] [EC:2.7.11.1]
109867514  [KO:K04503]
109867518  [KO:K04682]
109867800  [KO:K09993]
109867809  [KO:K06632] [EC:2.7.11.1]
109867928  [KO:K06672]
109867936  [KO:K04501]
109867950  [KO:K03349]
109867955  [KO:K05868]
109868300  [KO:K16198]
109868449  [KO:K04382] [EC:3.1.3.16]
109868689  [KO:K04402]
109868714  [KO:K04402]
109869060  [KO:K06670]
109869136  [KO:K10500]
109869437  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
109869536  [KO:K06636]
109869539  [KO:K17454]
109869785  [KO:K03083] [EC:2.7.11.26]
109869852  [KO:K16197]
109869933  [KO:K25163]
109870007  [KO:K04498] [EC:2.3.1.48]
109870437  [KO:K04683]
109870679  [KO:K03083] [EC:2.7.11.26]
109870917  [KO:K03353]
109871060  [KO:K06671]
109871429  [KO:K04683]
109871649  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
109871771  [KO:K03347]
109871974  [KO:K02212] [EC:5.6.2.3]
109872001  [KO:K11266]
109872257  [KO:K04402]
109872349  cdc20; cell division cycle protein 20 homolog [KO:K03363]
109872785  [KO:K03355]
109872962  [KO:K04382] [EC:3.1.3.16]
109873031  tp53; cellular tumor antigen p53 isoform X2 [KO:K04451]
109873114  [KO:K10779]
109873272  [KO:K17390]
109873349  [KO:K13375]
109873360  [KO:K03094]
109873451  [KO:K06630]
109873645  [KO:K21771]
109873704  [KO:K03349]
109873830  [KO:K06619] [EC:2.7.10.2]
109873979  ccna1; cyclin-A1 [KO:K06627]
109873995  [KO:K04382] [EC:3.1.3.16]
109874034  [KO:K16198]
109874051  [KO:K17390]
109874104  [KO:K04402]
109874105  [KO:K04402]
109874187  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
109874254  [KO:K03355]
109874256  cdc25c; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
109874313  [KO:K05868]
109874437  [KO:K13375]
109874461  [KO:K02542] [EC:5.6.2.3]
109874485  [KO:K02212] [EC:5.6.2.3]
109874548  [KO:K03364]
109874683  [KO:K03347]
109874868  [KO:K03364]
109874911  [KO:K04682]
109874940  [KO:K04377]
109874974  [KO:K16332]
109875040  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
109875044  [KO:K11547]
109875054  [KO:K06672]
109875136  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
109875313  [KO:K04402]
109875329  [KO:K11266]
109875635  rb1; retinoblastoma-associated protein [KO:K06618]
109875641  [KO:K06671]
109875810  [KO:K04501]
109876183  [KO:K06641] [EC:2.7.11.1]
109876409  [KO:K04498] [EC:2.3.1.48]
109876576  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
109876588  [KO:K06620]
109876628  crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
109876793  [KO:K16197]
109877018  [KO:K04500]
109877354  mtbp; mdm2-binding protein isoform X1 [KO:K26116]
109878079  [KO:K25229]
109878147  [KO:K09389]
109878219  [KO:K04685]
109878238  [KO:K03354]
109878339  [KO:K04382] [EC:3.1.3.16]
109878616  [KO:K06671]
109878643  [KO:K16198]
109879087  [KO:K02540] [EC:5.6.2.3]
109879117  [KO:K06625]
109879168  orc2; origin recognition complex subunit 2 [KO:K02604]
109879201  [KO:K06671]
109879386  [KO:K25228]
109879529  [KO:K13377]
109879859  [KO:K06619] [EC:2.7.10.2]
109880001  mcm6; DNA replication licensing factor MCM6 isoform X1 [KO:K02542] [EC:5.6.2.3]
109880053  cdc20b; cell division cycle protein 20 homolog B [KO:K03363]
109880228  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
109880541  [KO:K04382] [EC:3.1.3.16]
109881019  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
109881484  [KO:K06631] [EC:2.7.11.21]
109881514  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
109881561  [KO:K04802]
109881809  [KO:K06620]
109882449  [KO:K04682]
109882619  [KO:K02089] [EC:2.7.11.22]
109882628  [KO:K02206] [EC:2.7.11.22]
109882711  [KO:K13375]
109882804  [KO:K06670]
109883069  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
109883077  cdc25b; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
109883147  [KO:K04402]
109883210  [KO:K06629]
109883380  [KO:K13377]
109883520  [KO:K05866] [EC:3.1.3.48]
109883521  [KO:K06671]
109883676  [KO:K10151]
109883693  [KO:K09993]
109883694  [KO:K09993]
109883786  [KO:K23605]
109883797  [KO:K10779]
109884023  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
109884083  anapc4; anaphase-promoting complex subunit 4 isoform X4 [KO:K03351]
109884179  [KO:K02606]
109884502  [KO:K04382] [EC:3.1.3.16]
109884665  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
109884707  [KO:K21771]
109885447  [KO:K11584]
109885558  [KO:K06671]
109885596  [KO:K16332]
109885719  [KO:K10779]
109885836  [KO:K04503]
109885926  [KO:K06643] [EC:2.3.2.27]
109885927  [KO:K06643] [EC:2.3.2.27]
109886072  [KO:K06626]
109886073  [KO:K06620]
109886264  [KO:K04683]
109886270  [KO:K02180]
109886546  cdt1; DNA replication factor Cdt1 [KO:K10727]
109886656  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
109886712  [KO:K06679]
109886797  [KO:K10779]
109886933  [KO:K11267]
109887229  [KO:K06679]
109887396  [KO:K02180]
109887708  [KO:K06670]
109887722  [KO:K06620]
109887808  [KO:K21770]
109887857  [KO:K03358]
109887964  [KO:K06623]
109888272  [KO:K23605]
109888282  [KO:K16197]
109888389  [KO:K04682]
109888459  [KO:K06632] [EC:2.7.11.1]
109889082  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
109889097  [KO:K04402]
109889221  [KO:K11266]
109889380  [KO:K03358]
109889568  [KO:K10151]
109889574  e2f4; transcription factor E2F4 [KO:K04682]
109889610  [KO:K16332]
109889637  [KO:K11479] [EC:2.7.11.1]
109889644  [KO:K04503]
109889686  [KO:K09993]
109889848  [KO:K11584]
109889981  [KO:K25163]
109890002  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109890033  mtrf1l; peptide chain release factor 1-like, mitochondrial isoform X2 [KO:K10292]
109890347  [KO:K02606]
109890683  [KO:K03083] [EC:2.7.11.26]
109890756  [KO:K04377]
109890786  [KO:K16197]
109890956  [KO:K16197]
109891009  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
109891040  [KO:K04377]
109891102  [KO:K10152]
109891106  [KO:K06625]
109891773  [KO:K10779]
109891999  [KO:K02209] [EC:5.6.2.3]
109892486  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
109892488  [KO:K06672]
109892493  [KO:K04501]
109892655  [KO:K06671]
109892859  anapc13; anaphase-promoting complex subunit 13 isoform X1 [KO:K12456]
109892911  [KO:K06630]
109892950  [KO:K04382] [EC:3.1.3.16]
109892951  [KO:K03094]
109893030  [KO:K16198]
109893209  [KO:K03350]
109893282  [KO:K02091] [EC:2.7.11.22]
109893810  [KO:K09389]
109894180  [KO:K02213]
109894438  [KO:K11584]
109894503  [KO:K13377]
109894550  [KO:K06637] [EC:2.7.11.1]
109894563  [KO:K02206] [EC:2.7.11.22]
109894588  [KO:K06067] [EC:3.5.1.98]
109894642  [KO:K16197]
109894658  [KO:K02089] [EC:2.7.11.22]
109894692  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
109895006  [KO:K05868]
109895324  [KO:K06632] [EC:2.7.11.1]
109895385  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
109895461  [KO:K10727]
109895467  [KO:K04503]
109895481  [KO:K06626]
109895489  orc6; origin recognition complex subunit 6 [KO:K02608]
109895591  [KO:K04501]
109895630  [KO:K06634]
109895648  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
109895715  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
109895782  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
109895809  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
109895832  espl1; separin [KO:K02365] [EC:3.4.22.49]
109895960  [KO:K06625]
109896039  cdc45; cell division control protein 45 homolog [KO:K06628]
109896049  [KO:K04802]
109896151  [KO:K04402]
109896152  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
109896413  [KO:K11584]
109896474  [KO:K02537]
109896617  orc5; origin recognition complex subunit 5 [KO:K02607]
109896687  [KO:K10151]
109896771  [KO:K06625]
109896833  [KO:K06624]
109896882  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
109897084  [KO:K04451]
109897345  [KO:K04498] [EC:2.3.1.48]
109897410  [KO:K10151]
109897708  ticrr; treslin isoform X1 [KO:K26117]
109897719  [KO:K06632] [EC:2.7.11.1]
109898068  [KO:K04402]
109898294  [KO:K03350]
109898526  [KO:K03868] [EC:2.3.2.32]
109898529  [KO:K04498] [EC:2.3.1.48]
109898577  [KO:K03868] [EC:2.3.2.32]
109898654  [KO:K02209] [EC:5.6.2.3]
109899466  [KO:K04377]
109899651  [KO:K11584]
109899746  [KO:K25163]
109899760  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109899782  [KO:K03348]
109899783  [KO:K10292]
109899905  [KO:K02540] [EC:5.6.2.3]
109899951  mad2l1bp; MAD2L1-binding protein isoform X1 [KO:K26093]
109899985  [KO:K04498] [EC:2.3.1.48]
109900525  [KO:K06637] [EC:2.7.11.1]
109900602  [KO:K16197]
109900636  [KO:K02178] [EC:2.7.11.1]
109900747  [KO:K11268] [EC:2.3.1.-]
109900809  knl1; kinetochore scaffold 1 [KO:K11542]
109900944  [KO:K11584]
109901017  [KO:K03364]
109901337  [KO:K11584]
109901359  [KO:K06629]
109901607  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
109901938  [KO:K04501]
109901970  [KO:K06626]
109902227  [KO:K13376]
109902355  [KO:K04402]
109902469  [KO:K11266]
109902619  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
109902637  [KO:K03364]
109902765  [KO:K04402]
109902870  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
109902920  [KO:K08866] [EC:2.7.12.1]
109902942  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
109903713  [KO:K06670]
109903809  [KO:K11584]
109903892  [KO:K16197]
109903961  [KO:K06067] [EC:3.5.1.98]
109904055  [KO:K13377]
109904116  [KO:K11584]
109904367  [KO:K06067] [EC:3.5.1.98]
109904398  [KO:K02091] [EC:2.7.11.22]
109905293  [KO:K06627]
109905370  [KO:K03456]
109905504  [KO:K06630]
109905697  [KO:K16198]
109905879  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
109906035  [KO:K06635]
109906265  [KO:K04451]
109906776  [KO:K03083] [EC:2.7.11.26]
109906849  [KO:K02537]
109907038  [KO:K06670]
109907126  [KO:K06067] [EC:3.5.1.98]
109907201  [KO:K02091] [EC:2.7.11.22]
109907239  sgo1; shugoshin 1 isoform X1 [KO:K11580]
109907610  [KO:K06670]
109907728  [KO:K16197]
109907933  [KO:K04501]
109908064  [KO:K10500]
109908098  [KO:K17454]
109908176  [KO:K06626]
109908316  [KO:K06636]
109908449  [KO:K04501]
109908800  [KO:K04377]
109908852  [KO:K03456]
109908950  [KO:K06630]
109909109  [KO:K16198]
109909170  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
109909284  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
109909835  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
109909924  [KO:K03347]
109910179  [KO:K06671]
109910338  [KO:K13376]
116355402  [KO:K04498] [EC:2.3.1.48]
116358899  [KO:K06631] [EC:2.7.11.21]
116359793  [KO:K04683]
116362113  [KO:K26116]
116363463  [KO:K11547]
116364453  [KO:K25229]
116373141  [KO:K22399]
116375765  [KO:K06623]
Reference
PMID:7908906
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Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
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J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
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Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
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Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
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Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
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Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
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Nature 408:307-10 (2000)
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PMID:7973727
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Science 266:1376-80 (1994)
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Curr Biol 13:R104-14 (2003)
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Annu Rev Genet 38:203-32 (2004)
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Cell Cycle 9:3904-12 (2010)
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Related
pathway
oki03030  DNA replication
oki04010  MAPK signaling pathway
oki04120  Ubiquitin mediated proteolysis
oki04210  Apoptosis
KO pathway
ko04110   

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