KEGG   PATHWAY: oor04360
Entry
oor04360                    Pathway                                
Name
Axon guidance - Orcinus orca (killer whale)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
oor04360  Axon guidance
oor04360

Other DBs
GO: 0007411
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101289600  NTNG1; netrin-G1 isoform X1 [KO:K07522]
101277339  NTNG2; netrin-G2 isoform X2 [KO:K16359]
101278282  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
101277322  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
101275242  NTN1; netrin-1 [KO:K06843]
101272437  NTN3; netrin-3 [KO:K06844]
101285519  NTN4; netrin-4 isoform X1 [KO:K06845]
101282051  netrin receptor DCC [KO:K06765]
101281412  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101285216  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101274365  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
101273749  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
101283119  TRPC4; short transient receptor potential channel 4 [KO:K04967]
101274142  TRPC5; short transient receptor potential channel 5 [KO:K04968]
101274391  TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969]
101271019  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
101278517  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X3 [KO:K04348] [EC:3.1.3.16]
101286888  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7 [KO:K04348] [EC:3.1.3.16]
105748080  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
101272877  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101289855  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101285271  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101289117  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101275490  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101279266  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101274018  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101269741  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101278177  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101270289  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101287352  ABLIM2; actin-binding LIM protein 2 isoform X2 [KO:K07520]
101284222  ABLIM1; actin-binding LIM protein 1 isoform X5 [KO:K07520]
101276368  ABLIM3; actin-binding LIM protein 3 [KO:K07520]
101277943  NCK1; cytoplasmic protein NCK1 isoform X1 [KO:K07365]
101276477  cytoplasmic protein NCK1-like [KO:K07365]
101288086  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
101272383  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101272214  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
101278812  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101271942  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101288739  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101273830  RHOA; transforming protein RhoA [KO:K04513]
101278979  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101289250  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101275008  UNC5B; netrin receptor UNC5B isoform X1 [KO:K07521]
101282045  UNC5D; netrin receptor UNC5D [KO:K07521]
101288242  UNC5C; netrin receptor UNC5C isoform X2 [KO:K07521]
101281712  UNC5A; netrin receptor UNC5A isoform X2 [KO:K07521]
101288182  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X5 [KO:K07293] [EC:3.1.3.48]
101284587  RGMA; repulsive guidance molecule A isoform X2 [KO:K23096]
101279480  NEO1; neogenin isoform X6 [KO:K06766]
101270012  MYL5; myosin light chain 5 isoform X2 [KO:K12753]
101270950  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101290058  myosin regulatory light chain 12B [KO:K12757]
101289494  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
101272295  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101290254  LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609]
101273504  EFNA1; ephrin-A1 isoform X4 [KO:K05462]
101273928  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101274162  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
101270772  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101289545  EFNA2; ephrin-A2 [KO:K05462]
101285159  EFNB3; ephrin-B3 isoform X1 [KO:K05463]
101283099  EFNB1; ephrin-B1 isoform X3 [KO:K05463]
101282157  EFNB2; ephrin-B2 [KO:K05463]
101270456  EPHA1; ephrin type-A receptor 1 isoform X1 [KO:K05102] [EC:2.7.10.1]
101275767  EPHA2; ephrin type-A receptor 2 isoform X4 [KO:K05103] [EC:2.7.10.1]
101270211  EPHA3; ephrin type-A receptor 3 [KO:K05104] [EC:2.7.10.1]
101277721  EPHA4; ephrin type-A receptor 4 isoform X1 [KO:K05105] [EC:2.7.10.1]
101277666  EPHA5; ephrin type-A receptor 5 isoform X4 [KO:K05106] [EC:2.7.10.1]
101289645  EPHA6; ephrin type-A receptor 6 isoform X1 [KO:K05107] [EC:2.7.10.1]
101283296  EPHA7; ephrin type-A receptor 7 isoform X1 [KO:K05108] [EC:2.7.10.1]
101271520  EPHA8; ephrin type-A receptor 8 isoform X1 [KO:K05109] [EC:2.7.10.1]
101276364  EPHB1; ephrin type-B receptor 1 [KO:K05110] [EC:2.7.10.1]
101272607  EPHB2; ephrin type-B receptor 2 isoform X1 [KO:K05111] [EC:2.7.10.1]
101276616  EPHB3; ephrin type-B receptor 3 isoform X2 [KO:K05112] [EC:2.7.10.1]
101276506  EPHB4; ephrin type-B receptor 4 [KO:K05113] [EC:2.7.10.1]
101273628  EPHB6; ephrin type-B receptor 6 isoform X1 [KO:K05114] [EC:2.7.10.1]
101281151  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101284498  ENAH; protein enabled homolog isoform X5 [KO:K05746]
101276781  LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
101275044  RASA1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
101279850  NGEF; ephexin-1 isoform X2 [KO:K07525]
101271947  GTPase HRas-like isoform X4 [KO:K02833]
101286301  HRAS; GTPase HRas isoform X2 [KO:K02833]
101281897  KRAS; GTPase KRas isoform X2 [KO:K07827]
101276138  NRAS; GTPase NRas [KO:K07828]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101274780  NCK2; cytoplasmic protein NCK2 [KO:K19862]
101287887  RGS3; regulator of G-protein signaling 3 isoform X4 [KO:K07524]
101282620  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
101270504  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101276500  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101277471  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101271719  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101282064  SLIT1; slit homolog 1 protein [KO:K06838]
101289133  SLIT2; slit homolog 2 protein isoform X1 [KO:K06839]
101272351  SLIT3; slit homolog 3 protein [KO:K06850]
101271297  ROBO1; roundabout homolog 1 isoform X1 [KO:K06753]
101270406  ROBO2; roundabout homolog 2 isoform X1 [KO:K06754]
101288434  ROBO3; LOW QUALITY PROTEIN: roundabout homolog 3 [KO:K06755]
101289420  SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526]
101286379  SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X3 [KO:K07526]
101274068  SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X3 [KO:K07526]
101273232  SEMA3C; semaphorin-3C [KO:K06840]
101274386  SEMA3E; semaphorin-3E [KO:K06840]
101274882  SEMA3A; semaphorin-3A [KO:K06840]
101275132  SEMA3D; semaphorin-3D [KO:K06840]
101275583  SEMA3F; semaphorin-3F isoform X3 [KO:K06840]
101276748  SEMA3B; semaphorin-3B isoform X1 [KO:K06840]
101270696  SEMA3G; semaphorin-3G isoform X2 [KO:K06840]
101290045  PLXNA4; plexin-A4 isoform X3 [KO:K06820]
101269343  PLXNA2; plexin-A2 isoform X3 [KO:K06820]
101269203  PLXNA1; plexin-A1 isoform X1 [KO:K06820]
101273762  PLXNA3; plexin-A3 isoform X4 [KO:K06820]
101283100  NRP1; neuropilin-1 isoform X2 [KO:K06724]
101278883  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
101279549  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
101273335  LIM domain kinase 2 isoform X4 [KO:K05744] [EC:2.7.11.1]
101286878  CFL2; cofilin-2 [KO:K05765]
101275319  cofilin-2 [KO:K05765]
101272563  CFL1; cofilin-1 [KO:K05765]
101281772  cofilin-1-like [KO:K05765]
101269490  RHOD; rho-related GTP-binding protein RhoD [KO:K07530]
101271776  RND1; rho-related GTP-binding protein Rho6 [KO:K07531]
101272462  FES; tyrosine-protein kinase Fes/Fps isoform X1 [KO:K07527] [EC:2.7.10.2]
101290030  DPYSL5; dihydropyrimidinase-related protein 5 isoform X2 [KO:K07529]
101279812  DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528]
101281610  CDK5; cyclin-dependent kinase 5 isoform X2 [KO:K02090] [EC:2.7.11.22]
101283259  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101277700  SEMA4F; semaphorin-4F isoform X1 [KO:K06521]
101283983  SEMA4G; semaphorin-4G [KO:K06521]
101277037  SEMA4B; semaphorin-4B [KO:K06521]
101282629  SEMA4A; semaphorin-4A [KO:K06521]
101287670  SEMA4C; semaphorin-4C [KO:K06521]
101281241  SEMA4D; semaphorin-4D isoform X1 [KO:K06521]
101284928  SEMA5A; semaphorin-5A isoform X1 [KO:K06841]
101271288  SEMA5B; semaphorin-5B [KO:K06841]
101274247  SEMA6D; semaphorin-6D isoform X3 [KO:K06842]
101269981  SEMA6B; semaphorin-6B isoform X1 [KO:K06842]
101274406  SEMA6C; semaphorin-6C isoform X3 [KO:K06842]
101281481  SEMA6A; semaphorin-6A isoform X1 [KO:K06842]
101288252  PLXNB2; plexin-B2 [KO:K06821]
101283630  PLXNB1; plexin-B1 isoform X2 [KO:K06821]
101282210  PLXNB3; plexin-B3 isoform X1 [KO:K06821]
101280136  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101272984  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101273601  RRAS; ras-related protein R-Ras [KO:K07829]
101285016  SEMA7A; semaphorin-7A isoform X1 [KO:K06529]
101288393  PLXNC1; plexin-C1 [KO:K06572]
101283510  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101270161  SHH; sonic hedgehog protein [KO:K11988]
101284461  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101275764  SMO; smoothened homolog isoform X1 [KO:K06226]
101276350  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101289017  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101272014  BOC; brother of CDO isoform X1 [KO:K20020]
101278965  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
101289426  WNT5B; protein Wnt-5b [KO:K00444]
101285690  FZD3; frizzled-3 isoform X2 [KO:K02329]
101274452  RYK; tyrosine-protein kinase RYK isoform X2 [KO:K05128] [EC:2.7.10.1]
101279065  LOW QUALITY PROTEIN: tyrosine-protein kinase RYK-like [KO:K05128] [EC:2.7.10.1]
101269181  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X16 [KO:K04515] [EC:2.7.11.17]
101287513  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
101281498  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X8 [KO:K04515] [EC:2.7.11.17]
101271879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101270876  WNT4; protein Wnt-4 isoform X2 [KO:K00408]
101278075  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101278974  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101283011  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101277568  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101285437  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101281352  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101270868  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101280921  PARD3; partitioning defective 3 homolog isoform X3 [KO:K04237]
101283233  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101284950  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101288617  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
101286488  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101284187  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101289880  SSH2; protein phosphatase Slingshot homolog 2 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101271213  SSH1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101283186  BMP7; bone morphogenetic protein 7 isoform X2 [KO:K16621]
101281504  GDF7; growth/differentiation factor 7 [KO:K20013]
101276638  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
101287667  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
oor04010  MAPK signaling pathway
oor04060  Cytokine-cytokine receptor interaction
oor04310  Wnt signaling pathway
oor04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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