KEGG   PATHWAY: pcoc04820
Entry
pcoc04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Phasianus colchicus (Ring-necked pheasant)
Class
Cellular Processes; Cell motility
Pathway map
pcoc04820  Cytoskeleton in muscle cells
pcoc04820

Organism
Phasianus colchicus (Ring-necked pheasant) [GN:pcoc]
Gene
116243191  COL1A2; collagen alpha-2(I) chain [KO:K06236]
116233567  COL1A1; collagen alpha-1(I) chain [KO:K06236]
116235945  COL3A1; collagen alpha-1(III) chain [KO:K19720]
116235944  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
116243470  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
116243511  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
116234186  collagen alpha-1(XXVII) chain-like [KO:K19721]
116234314  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
116234425  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
116226909  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
116240621  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
116229980  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
116233511  DCN; decorin [KO:K04660]
116239428  VCAN; versican core protein [KO:K06793]
116228212  ELN; elastin isoform X1 [KO:K14211]
116236015  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
116236017  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
116236043  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
116227157  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
116229306  THBS1; thrombospondin-1 [KO:K16857]
116239913  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
116235732  COMP; cartilage oligomeric matrix protein [KO:K04659]
116242529  THBS2; thrombospondin-2 [KO:K04659]
116225312  FBN1; fibrillin-1 [KO:K06825]
116236591  FBN2; fibrillin-2 [KO:K23342]
116240201  fibrillin-2-like [KO:K23342]
116230910  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116230911  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
116229773  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116229774  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
116242782  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
116242783  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
116231457  FBLN1; fibulin-1 isoform X1 [KO:K17307]
116238779  FBLN2; fibulin-2 [KO:K17307]
116238347  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
116228373  NID1; nidogen-1 [KO:K06826]
116234599  NID2; nidogen-2 [KO:K06826]
116236056  FN1; fibronectin isoform X1 [KO:K05717]
116240434  SDC1; syndecan-1 [KO:K06257]
116227630  SDC2; syndecan-2 [KO:K16336]
116230145  SDC3; syndecan-3 isoform X1 [KO:K16337]
116227612  SDC4; syndecan-4 isoform X1 [KO:K16338]
116242594  AGRN; agrin isoform X1 [KO:K06254]
116242193  DSC2; desmocollin-2 [KO:K07601]
116242182  DSG2; desmoglein-2 [KO:K07597]
116226832  PKP2; plakophilin-2 [KO:K12642]
116233640  JUP; junction plakoglobin [KO:K10056]
116226437  DSP; desmoplakin isoform X1 [KO:K10381]
116243216  VIM; vimentin [KO:K07606]
116232951  DES; desmin [KO:K07610]
116243146  LAMA2; laminin subunit alpha-2 [KO:K05637]
116226193  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
116239367  ITGA1; integrin alpha-1 [KO:K06480]
116239363  ITGA2; integrin alpha-2 [KO:K06481]
116233844  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
116233757  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
116234039  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
116232854  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
116235217  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
116243334  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
116238595  ITGA9; integrin alpha-9 [KO:K06585]
116225486  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
116235937  ITGAV; integrin alpha-V [KO:K06487]
116244388  ITGB1; integrin beta-1 [KO:K05719]
116232589  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
116227388  ITGB5; integrin beta-5 [KO:K06588]
116232931  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
116227022  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
116244612  TLN2; talin-2 [KO:K06271]
116239708  TLN1; talin-1 [KO:K06271]
116235080  VCL; vinculin isoform X1 [KO:K05700]
116228453  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
116237546  ACTB; actin, cytoplasmic 1 [KO:K05692]
116244547  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
116232509  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116234494  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
116241100  DAG1; dystroglycan [KO:K06265]
116233759  SGCA; alpha-sarcoglycan [KO:K12565]
116243292  SGCE; LOW QUALITY PROTEIN: epsilon-sarcoglycan [KO:K27061]
116225904  SGCB; beta-sarcoglycan [KO:K12566]
116232113  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
116244198  SGCG; gamma-sarcoglycan [KO:K12564]
116225982  SGCZ; zeta-sarcoglycan [KO:K27062]
116231422  SSPN; sarcospan [KO:K22194]
116232724  DMD; dystrophin isoform X1 [KO:K10366]
116235136  SNTA1; alpha-1-syntrophin [KO:K24063]
116243686  SNTB2; beta-2-syntrophin [KO:K24064]
116227710  SNTB1; beta-1-syntrophin [KO:K24064]
116242241  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
116238833  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
116242449  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
116230889  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
116234895  ATP1B4; protein ATP1B4 [KO:K01540]
116242440  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 isoform X1 [KO:K01540]
116226908  ANK3; ankyrin-3 isoform X1 [KO:K09259]
116234212  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
116231863  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
116228999  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
116237942  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
116226734  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
116238735  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
116235140  MYH7B; myosin-7B [KO:K24220]
116242433  MYH15; myosin-15 [KO:K24220]
116235564  myosin heavy chain, skeletal muscle, adult isoform X1 [KO:K24220]
116235565  myosin heavy chain, skeletal muscle, adult-like [KO:K24220]
116235571  myosin heavy chain, skeletal muscle, adult-like [KO:K24220]
116235572  myosin heavy chain, skeletal muscle, adult-like [KO:K24220]
116235573  myosin-1B-like [KO:K24220]
116235574  myosin-1B-like [KO:K24220]
116240188  myosin-7 [KO:K17751]
116228246  myosin-7-like [KO:K17751]
116237475  MYH11; myosin-11 isoform X1 [KO:K10352]
116232668  MYH10; myosin-10 isoform X1 [KO:K10352]
116233292  MYH9; myosin-9 isoform X1 [KO:K10352]
116235997  MYL1; myosin light chain 1/3, skeletal muscle isoform [KO:K05738]
116238242  MYL3; myosin light chain 3 [KO:K12749]
116233806  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
116228589  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116236856  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116226761  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
116228992  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
116238780  MYBPH; myosin-binding protein H [KO:K24494]
116242793  ACTA1; actin, alpha skeletal muscle [KO:K10354]
116229100  actin, alpha cardiac muscle 1-like isoform X1 [KO:K12314]
116229330  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
116239338  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
116238743  TNNI1; troponin I, slow skeletal muscle isoform X1 [KO:K10371]
116239626  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
116225705  TNNC2; troponin C, skeletal muscle [KO:K12042]
116242983  TNNI2; troponin I, fast skeletal muscle isoform X1 [KO:K12043]
116242895  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
116239621  TNNI3; troponin I, cardiac muscle [KO:K12044]
116238742  TNNT2; troponin T, cardiac muscle [KO:K12045]
116244609  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
116239687  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
116237314  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
116235681  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
116234048  TTN; titin [KO:K12567] [EC:2.7.11.1]
116232194  MYOT; myotilin isoform X1 [KO:K19875]
116233695  TCAP; telethonin [KO:K19879]
116231245  SYNPO2; synaptopodin-2 [KO:K24066]
116227277  NEB; nebulin [KO:K18267]
116243343  NEBL; nebulette [KO:K25865]
116235120  MYOZ1; myozenin-1 [KO:K26050]
116231243  MYOZ2; myozenin-2 [KO:K26050]
116232144  MYOZ3; myozenin-3 [KO:K26050]
116232232  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
116238914  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
116235104  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
116236881  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
116243973  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
116231832  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
116242559  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
116238261  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
116231791  NRAP; nebulin-related-anchoring protein [KO:K24421]
116234999  MYPN; myopalladin [KO:K22028]
116231275  PDLIM5; PDZ and LIM domain protein 5 [KO:K19867]
116232068  PDLIM7; PDZ and LIM domain protein 7 [KO:K19867]
116234702  LDB3; LIM domain-binding protein 3 [KO:K19867]
116244689  tropomodulin-3-like [KO:K10370]
116244690  tropomodulin-2 [KO:K10370]
116238464  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
116239450  TMOD1; tropomodulin-1 [KO:K10370]
116239998  ZYX; zyxin isoform X1 [KO:K06273]
116229642  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
116236517  FHL2; four and a half LIM domains protein 2 [KO:K14380]
116230036  FHL3; four and a half LIM domains protein 3 isoform X1 [KO:K24414]
116237052  LMOD3; leiomodin-3 [KO:K22030]
116244305  LMOD2; leiomodin-2 [KO:K22030]
116238733  LMOD1; leiomodin-1 [KO:K22030]
116240085  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
116231724  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
116236088  formin-like protein 3 [KO:K23957]
116227464  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
116233852  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
116228803  inverted formin-2-like isoform X1 [KO:K23958]
116228802  inverted formin-2-like [KO:K23958]
116236623  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
116229622  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
116229664  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
116243324  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
116228485  FMN2; formin-2 isoform X1 [KO:K02184]
116230161  MYOM3; myomesin-3 [KO:K24495]
116226180  MYOM1; myomesin-1 [KO:K24495]
116240521  MYOM2; myomesin-2 [KO:K24495]
116239950  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
116242528  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
116231257  ANK2; ankyrin-2 [KO:K09255]
116241362  creatine kinase M-type-like [KO:K27382] [EC:2.7.3.2]
116230664  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
116236243  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
116229909  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
116243043  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
116236991  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
116238752  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
116238304  OBSCN; obscurin [KO:K17531] [EC:2.7.11.1]
116237306  PLEC; plectin [KO:K10388]
116228877  SYNE3; nesprin-3 [KO:K21761]
116241268  SYNE1; nesprin-1 isoform X1 [KO:K19326]
116236794  SYNE2; nesprin-2 isoform X1 [KO:K19346]
116237611  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
116233348  SUN2; SUN domain-containing protein 2 [KO:K19347]
116237925  TMEM43; transmembrane protein 43 [KO:K27488]
116230962  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
116236207  LMNB2; lamin-B2 [KO:K07611]
116225352  lamin-L(III)-like [KO:K07611]
116238181  LMNB1; lamin-B1 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
pcoc04512  ECM-receptor interaction
pcoc04814  Motor proteins
KO pathway
ko04820   
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