KEGG   PATHWAY: pcub03040
Entry
pcub03040                   Pathway                                
Name
Spliceosome - Psilocybe cubensis (magic mushroom)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pcub03040  Spliceosome
pcub03040

Other DBs
GO: 0005681
Organism
Psilocybe cubensis (magic mushroom) [GN:pcub]
Gene
JR316_0000234  [KO:K12897]
JR316_0000371  [KO:K12818] [EC:3.6.4.13]
JR316_0000417  [KO:K12847]
JR316_0000499  [KO:K12852]
JR316_0000631  [KO:K12826]
JR316_0000725  [KO:K11097]
JR316_0000834  [KO:K11096]
JR316_0000931  [KO:K12839]
JR316_0001099  [KO:K12624]
JR316_0001113  [KO:K12816]
JR316_0001116  [KO:K10599] [EC:2.3.2.27]
JR316_0001140  [KO:K11092]
JR316_0001254  [KO:K12815] [EC:3.6.4.13]
JR316_0001658  [KO:K12830]
JR316_0001930  [KO:K12621]
JR316_0002013  [KO:K12848]
JR316_0002069  [KO:K12819]
JR316_0002090  [KO:K12842]
JR316_0002338  [KO:K11088]
JR316_0002345  [KO:K12836]
JR316_0002520  [KO:K12863]
JR316_0002631  [KO:K12623]
JR316_0003228  [KO:K12825]
JR316_0003288  [KO:K12860]
JR316_0003366  [KO:K12871]
JR316_0003437  [KO:K12893]
JR316_0003445  [KO:K06063]
JR316_0003458  [KO:K12883]
JR316_0003523  [KO:K03283]
JR316_0003542  [KO:K12831]
JR316_0003558  [KO:K11094]
JR316_0003591  [KO:K12872]
JR316_0003646  [KO:K12867]
JR316_0003675  [KO:K12849]
JR316_0003703  [KO:K12858] [EC:3.6.4.13]
JR316_0003820  [KO:K03283]
JR316_0003924  [KO:K12733] [EC:5.2.1.8]
JR316_0003941  [KO:K12845]
JR316_0004031  [KO:K12829]
JR316_0004346  [KO:K12857]
JR316_0004490  [KO:K12811] [EC:3.6.4.13]
JR316_0004676  [KO:K12622]
JR316_0004722  [KO:K11098]
JR316_0004726  [KO:K12824]
JR316_0004795  [KO:K12864]
JR316_0004872  [KO:K12833]
JR316_0004873  [KO:K13025] [EC:3.6.4.13]
JR316_0004946  [KO:K12844]
JR316_0006051  [KO:K12823] [EC:3.6.4.13]
JR316_0006063  [KO:K11093]
JR316_0006067  [KO:K12817]
JR316_0006267  [KO:K11984]
JR316_0006873  [KO:K12813] [EC:3.6.4.13]
JR316_0007104  [KO:K12856]
JR316_0007564  [KO:K12855]
JR316_0007970  [KO:K12662]
JR316_0008068  [KO:K12834]
JR316_0008151  [KO:K12828]
JR316_0008170  [KO:K12837]
JR316_0008218  [KO:K11086]
JR316_0008842  [KO:K12881]
JR316_0008901  [KO:K12627]
JR316_0009050  [KO:K12869]
JR316_0009260  [KO:K11087]
JR316_0009525  [KO:K12854] [EC:3.6.4.13]
JR316_0009927  [KO:K12843]
JR316_0009964  [KO:K12625]
JR316_0010869  [KO:K12626]
JR316_0012150  [KO:K09567] [EC:5.2.1.8]
JR316_0012156  [KO:K12859]
JR316_0012422  [KO:K12862]
JR316_0012472  [KO:K12877]
JR316_0012623  [KO:K12820] [EC:3.6.4.13]
JR316_0012956  [KO:K12870]
JR316_0013157  [KO:K12868]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

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