Entry Name B cell receptor signaling pathway - Pongo abelii (Sumatran orangutan)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map pon04662 B cell receptor signaling pathway
Ortholog table Other DBs Organism Pongo abelii (Sumatran orangutan) [GN:
pon ]
Gene 100438225 CD79A; B-cell antigen receptor complex-associated protein alpha chain isoform X1 [KO:K06506 ]
100449702 CD79B; B-cell antigen receptor complex-associated protein beta chain isoform X1 [KO:K06507 ]
100456577 DAPP1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide isoform X2 [KO:K12229 ]
112129584 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100460856 BANK1; B-cell scaffold protein with ankyrin repeats isoform X2 [KO:K26239 ]
100174530 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
100455542 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100436675 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X9 [KO:K04348 ] [EC:3.1.3.16 ]
100436209 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
100450332 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
100458008 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333 ]
100461490 CARD11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
100452420 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
100461595 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100446325 NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872 ]
100174298 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
100173589 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
100437617 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100432846 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100453779 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103889133 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100453137 FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560 ]
103888690 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
100433990 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1 [KO:K06512 ]
100442931 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily B member 5 [KO:K06512 ]
100459365 LILRA4; leukocyte immunoglobulin-like receptor subfamily A member 4 isoform X1 [KO:K06512 ]
100459988 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512 ]
100434743 LILRB4; leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1 [KO:K06512 ]
100434369 leukocyte immunoglobulin-like receptor subfamily A member 2 isoform X3 [KO:K06512 ]
100458638 LILRB3; leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1 [KO:K06512 ]
112130091 LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512 ]
112128484 LILRA5; leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X2 [KO:K06512 ]
100432416 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform X1 [KO:K06512 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related pon04610 Complement and coagulation cascades
pon04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
