KEGG   PATHWAY: ppug04068
Entry
ppug04068                   Pathway                                
Name
FoxO signaling pathway - Pungitius pungitius (ninespine stickleback)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
ppug04068  FoxO signaling pathway
ppug04068

Other DBs
GO: 0009267
Organism
Pungitius pungitius (ninespine stickleback) [GN:ppug]
Gene
119217376  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
119210068  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
119197865  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
119227800  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119195082  transforming growth factor beta-3 proprotein-like [KO:K13377]
119198357  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
119219642  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
119229310  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
119197680  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
119198112  mothers against decapentaplegic homolog 4-like [KO:K04501]
119224476  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
119218763  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
119226199  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
119198624  mothers against decapentaplegic homolog 3 [KO:K23605]
119196208  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
119209121  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
119226447  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
119217013  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119226713  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
119209826  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
119225005  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b isoform X1 [KO:K07199]
119198785  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
119219742  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
119228510  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
119209338  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
119229449  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
119220941  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
119216337  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
119226275  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
119211374  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119210080  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
119220189  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
119220793  ep300b; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
119218111  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
119212555  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
119214011  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
119219989  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
119222591  solute carrier family 2, facilitated glucose transporter member 4-like isoform X1 [KO:K07191]
119213781  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119210947  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119212533  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119226214  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
119194222  serine/threonine-protein kinase 4-like [KO:K04411]
119207003  insulin-like growth factor I [KO:K05459]
119210507  igf1; insulin-like growth factor I [KO:K05459]
119198402  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
119195567  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
119215349  ins; insulin [KO:K04526]
119209490  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
119217181  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
119215070  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
119222532  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
119213930  insulin receptor substrate 2-like [KO:K07187]
119228584  irs2b; insulin receptor substrate 2 [KO:K07187]
119222867  insulin receptor substrate 2-B [KO:K07187]
119213100  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
119209321  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119222704  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119217096  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
119223188  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119226302  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119209332  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119209420  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
119216917  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
119216976  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
119224672  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
119213165  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119213096  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
119214000  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
119224939  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119214113  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119212840  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119213889  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119227745  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119211112  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119217961  akt3b; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119219595  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
119195264  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119222443  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
119198674  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
119215831  forkhead box protein O1-A-like [KO:K07201]
119210253  foxo1a; forkhead box protein O1-A [KO:K07201]
119219610  foxo6b; forkhead box protein O6b [KO:K09408]
119228109  foxo3a; forkhead box protein O3a [KO:K09408]
119194549  foxo3b; forkhead box protein O3B [KO:K09408]
119211188  foxo4; forkhead box protein O4 [KO:K12358]
119197981  forkhead box protein O3-like [KO:K17847]
119227715  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
119195374  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
119226710  homer protein homolog 1 [KO:K15010]
119209114  homer protein homolog 3-like isoform X1 [KO:K15010]
119216507  homer3b; homer protein homolog 3b isoform X1 [KO:K15010]
119224704  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
119226014  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
119222444  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
119229976  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
119213123  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
119219903  casein kinase I [KO:K08960] [EC:2.7.11.1]
119219687  interleukin-6-like [KO:K05405]
119194249  il10; interleukin-10 [KO:K05443]
119220174  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119211628  egf; pro-epidermal growth factor [KO:K04357]
119198448  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
119204022  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
119219897  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
119228081  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119217531  son of sevenless homolog 1-like [KO:K03099]
119196409  GTPase HRas [KO:K02833]
119220140  zgc:55558 [KO:K07827]
119195920  kras; GTPase KRas isoform X1 [KO:K07827]
119210797  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
119221983  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
119224747  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119195764  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119209642  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
119216703  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
119219913  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119224898  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119221846  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
119222286  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
119222347  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119210172  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119210173  mapk12b; mitogen-activated protein kinase 12b isoform X1 [KO:K04441] [EC:2.7.11.24]
119229842  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
119196584  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119194166  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
119220676  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
119214233  foxg1b; forkhead box protein G1b [KO:K09385]
119227405  foxg1a; forkhead box protein G1 [KO:K09385]
119211229  foxg1c; forkhead box protein G1c [KO:K09385]
119227097  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
119199458  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
119193944  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
119211129  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
119222960  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
119196637  G1/S-specific cyclin-D1-like [KO:K04503]
119196950  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119220523  ccndx; cyclin Dx [KO:K10151]
119210383  G1/S-specific cyclin-D2-like [KO:K10151]
119196050  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
119226279  ccng2; cyclin-G2 [KO:K10146]
119225195  cyclin-G2-like [KO:K10146]
119217634  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119218475  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
119210451  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
119229970  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
119196337  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
119211423  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
119196387  rbl2; retinoblastoma-like protein 2 [KO:K16332]
119217929  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
119225563  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
119209629  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
119227173  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
119226722  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
119226767  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
119209885  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
119216270  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
119217248  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
119225616  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
119210096  cd40lg; CD40 ligand [KO:K04389]
119217173  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119214319  bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
119198677  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
119227889  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
119208292  bcl6ab; BCL6A transcription repressor b isoform X1 [KO:K15618]
119216731  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
119226315  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
119214104  bnip4; BCL2 interacting protein 4 [KO:K15464]
119221863  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
119196602  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119196798  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
119197290  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
119196562  cat; catalase [KO:K03781] [EC:1.11.1.6]
119194694  sod2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
119215964  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
119198660  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
119194038  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
119212915  LOW QUALITY PROTEIN: glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
119212917  g6pca.2; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
119212944  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
119227036  interleukin-7 receptor subunit alpha-like [KO:K05072]
119209859  Krueppel-like factor 2 [KO:K17845]
119217024  Krueppel-like factor 2 [KO:K17845]
119217083  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
119216649  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
119196032  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
119196233  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
119194960  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
119197926  fbxo32; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
ppug00010  Glycolysis / Gluconeogenesis
ppug00020  Citrate cycle (TCA cycle)
ppug00190  Oxidative phosphorylation
ppug04010  MAPK signaling pathway
ppug04110  Cell cycle
ppug04120  Ubiquitin mediated proteolysis
ppug04140  Autophagy - animal
ppug04210  Apoptosis
ppug04350  TGF-beta signaling pathway
ppug04910  Insulin signaling pathway
KO pathway
ko04068   
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