KEGG   PATHWAY: rphi04148
Entry
rphi04148                   Pathway                                
Name
Efferocytosis - Ruditapes philippinarum (Manila clam)
Class
Cellular Processes; Transport and catabolism
Pathway map
rphi04148  Efferocytosis
rphi04148

Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132712765  [KO:K02187] [EC:3.4.22.56]
132712766  [KO:K04397] [EC:3.4.22.60]
132712767  [KO:K02187] [EC:3.4.22.56]
132712872  [KO:K08765] [EC:2.3.1.21]
132713188  [KO:K24068]
132713195  [KO:K26811]
132713405  [KO:K05725] [EC:2.7.10.2]
132713483  [KO:K06129] [EC:3.1.1.5]
132713523  [KO:K00411] [EC:7.1.1.8]
132713544  [KO:K23285]
132713553  [KO:K06704] [EC:3.4.24.81]
132713580  [KO:K08530]
132713894  [KO:K08268]
132714358  [KO:K20179]
132714667  [KO:K06704] [EC:3.4.24.81]
132714705  [KO:K03987]
132715541  [KO:K07888]
132715829  [KO:K20184]
132715987  [KO:K17253]
132716085  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132716161  [KO:K06704] [EC:3.4.24.81]
132716179  [KO:K24068]
132716619  [KO:K07293] [EC:3.1.3.48]
132717017  [KO:K26935]
132718789  [KO:K20182]
132719291  [KO:K02187] [EC:3.4.22.56]
132719644  [KO:K01581] [EC:4.1.1.17]
132719719  [KO:K04261]
132719732  [KO:K01476] [EC:3.5.3.1]
132719801  [KO:K04392]
132719952  [KO:K24318]
132720177  [KO:K05641]
132720393  [KO:K02187] [EC:3.4.22.56]
132720727  [KO:K24068]
132721796  [KO:K06059] [EC:3.4.24.86]
132721819  [KO:K06059] [EC:3.4.24.86]
132722141  [KO:K04392]
132722461  [KO:K08179]
132723485  [KO:K07881]
132723728  [KO:K08179]
132724129  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132724159  [KO:K04438]
132724823  [KO:K04368] [EC:2.7.12.2]
132724888  [KO:K07299]
132724957  [KO:K20180]
132725050  [KO:K08530]
132725464  [KO:K08765] [EC:2.3.1.21]
132725606  [KO:K00461] [EC:1.13.11.34]
132726881  [KO:K08524]
132728138  [KO:K19501]
132729246  [KO:K05870]
132731261  [KO:K01052] [EC:3.1.1.13]
132731289  [KO:K04718] [EC:2.7.1.91]
132731484  [KO:K04397] [EC:3.4.22.60]
132731502  [KO:K06704] [EC:3.4.24.81]
132731503  [KO:K06704] [EC:3.4.24.81]
132731730  [KO:K24068]
132731799  [KO:K06535]
132732172  [KO:K04371] [EC:2.7.11.24]
132732396  [KO:K06704] [EC:3.4.24.81]
132732397  [KO:K06704] [EC:3.4.24.81]
132732424  [KO:K04392]
132732543  [KO:K17253]
132733704  [KO:K04515] [EC:2.7.11.17]
132734566  [KO:K04438]
132734567  [KO:K04438]
132735294  [KO:K11987] [EC:1.14.99.1]
132735627  [KO:K06704] [EC:3.4.24.81]
132735969  [KO:K16343] [EC:3.1.1.4]
132736179  [KO:K04397] [EC:3.4.22.60]
132736180  [KO:K04397] [EC:3.4.22.60]
132736528  [KO:K10223] [EC:1.14.99.38]
132736891  [KO:K04441] [EC:2.7.11.24]
132736951  [KO:K00461] [EC:1.13.11.34]
132737182  [KO:K04397] [EC:3.4.22.60]
132737183  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
132737340  [KO:K11987] [EC:1.14.99.1]
132739217  [KO:K04504]
132739438  [KO:K20183]
132739439  [KO:K20183]
132739591  [KO:K05853] [EC:7.2.2.10]
132739707  [KO:K26934]
132739841  [KO:K06259]
132740604  [KO:K23678]
132740673  [KO:K01581] [EC:4.1.1.17]
132740682  [KO:K01581] [EC:4.1.1.17]
132741417  [KO:K13708]
132742252  [KO:K04397] [EC:3.4.22.60]
132742392  [KO:K20178]
132742403  [KO:K04261]
132742405  [KO:K04261]
132742408  [KO:K04261]
132742566  [KO:K24068]
132742712  [KO:K04443] [EC:2.7.11.1]
132743313  [KO:K24068]
132743605  [KO:K14802] [EC:7.6.2.1]
132744104  [KO:K04261]
132744168  [KO:K06704] [EC:3.4.24.81]
132744778  [KO:K04261]
132744926  [KO:K02187] [EC:3.4.22.56]
132745336  [KO:K00411] [EC:7.1.1.8]
132745464  [KO:K04550]
132745710  [KO:K03987]
132746359  [KO:K04397] [EC:3.4.22.60]
132746430  [KO:K12366]
132746723  [KO:K09355]
132746934  [KO:K08765] [EC:2.3.1.21]
132747047  [KO:K26935]
132747297  [KO:K04397] [EC:3.4.22.60]
132747636  [KO:K26811]
132748333  [KO:K03986]
132748366  [KO:K19501]
132748702  [KO:K24068]
132749019  [KO:K04261]
132749167  [KO:K04368] [EC:2.7.12.2]
132749562  [KO:K24068]
132749566  [KO:K04441] [EC:2.7.11.24]
132749997  [KO:K17398] [EC:2.1.1.37]
132750515  [KO:K04397] [EC:3.4.22.60]
132750516  [KO:K04397] [EC:3.4.22.60]
132750712  [KO:K09097]
132750885  [KO:K19480]
132752043  [KO:K02187] [EC:3.4.22.56]
132752075  [KO:K07897]
132752568  [KO:K02187] [EC:3.4.22.56]
132753730  [KO:K07299]
132754139  [KO:K00461] [EC:1.13.11.34]
132754549  [KO:K04261]
132755592  [KO:K01581] [EC:4.1.1.17]
132755595  [KO:K01581] [EC:4.1.1.17]
132755597  [KO:K01581] [EC:4.1.1.17]
132755960  [KO:K04392]
132756112  [KO:K20177]
132756467  [KO:K08535]
132756980  [KO:K20181]
132757137  [KO:K00461] [EC:1.13.11.34]
132757280  [KO:K24068]
132757366  [KO:K08536]
132757808  [KO:K08057]
132759084  [KO:K00461] [EC:1.13.11.34]
132760575  [KO:K06129] [EC:3.1.1.5]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
rphi00010  Glycolysis / Gluconeogenesis
rphi04140  Autophagy - animal
rphi04145  Phagosome
KO pathway
ko04148   

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