KEGG   PATHWAY: smau04514
Entry
smau04514                   Pathway                                
Name
Cell adhesion molecules - Scophthalmus maximus (turbot)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
smau04514  Cell adhesion molecules
smau04514

Other DBs
GO: 0050839
Organism
Scophthalmus maximus (turbot) [GN:smau]
Gene
124850731  uncharacterized protein LOC124850731 [KO:K06492]
118315868  uncharacterized protein LOC118315868 [KO:K06449]
118301021  T-cell surface antigen CD2-like isoform X1 [KO:K06449]
118283356  vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
118299474  igsf11; immunoglobulin superfamily member 11 [KO:K06791]
118300190  zgc:165604; immunoglobulin superfamily member 11 [KO:K06791]
118285256  butyrophilin subfamily 2 member A2 [KO:K06745]
118299819  CD276 antigen isoform X1 [KO:K05413]
118282697  cd28; cytotoxic T-lymphocyte protein 4 [KO:K06538]
118318756  ICOS ligand [KO:K06710]
118316572  H-2 class II histocompatibility antigen, A-U alpha chain isoform X1 [KO:K06752]
118316590  H-2 class II histocompatibility antigen, E-S beta chain isoform X1 [KO:K06752]
118285121  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
118284801  mamu class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
118288947  M1-specific T cell receptor beta chain-like [KO:K10785]
118315132  cd4-1; CD4-1 molecule [KO:K06454]
118291636  H-2 class I histocompatibility antigen, L-D alpha chain isoform X1 [KO:K06751]
118292341  BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
118292360  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
118292497  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
118292263  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
124849783  major histocompatibility complex class I-related gene protein-like [KO:K06751]
124849784  major histocompatibility complex class I-related gene protein-like [KO:K06751]
124849785  major histocompatibility complex class I-related gene protein-like [KO:K06751]
118292361  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
118309077  cd8a; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
118308978  cd8b; uncharacterized protein cd8b [KO:K06459]
118302278  cd276; CD276 antigen isoform X1 [KO:K06746]
118320353  vtcn1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
118316527  cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118315341  tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118299692  CD166 antigen homolog A isoform X1 [KO:K06547]
118300154  CD166 antigen homolog isoform X1 [KO:K06547]
118291739  deleted in malignant brain tumors 1 protein-like isoform X1 [KO:K06456]
118291238  cd226; CD226 antigen isoform X1 [KO:K06567]
118315053  si:ch73-22o12.1; nectin-2 isoform X1 [KO:K06531]
118313260  zmp:0000001082; integrin alpha-D [KO:K05718]
118283150  itgb2; integrin beta-2 [KO:K06464]
118316330  si:dkey-33i11.1; B-cell receptor CD22 [KO:K06467]
118312331  B-cell receptor CD22-like isoform X1 [KO:K06467]
118312332  B-cell receptor CD22 isoform X1 [KO:K06467]
118312535  uncharacterized protein LOC118312535 [KO:K06467]
118312694  sialoadhesin isoform X1 [KO:K06467]
118312695  B-cell receptor CD22-like isoform X1 [KO:K06467]
124849358  B-cell receptor CD22-like [KO:K06467]
118299253  si:dkey-24p1.1; B-cell receptor CD22 isoform X1 [KO:K06467]
118315041  B-cell receptor CD22 isoform X1 [KO:K06467]
118311883  myelin-associated glycoprotein-like [KO:K06467]
118318805  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
118301317  nectin3b; nectin-3-like protein isoform X1 [KO:K06592]
118299303  nectin3a; nectin-3-like protein [KO:K06592]
118299767  claudin-3-like [KO:K06087]
118300039  claudin-15 isoform X1 [KO:K06087]
118300058  cldn2; claudin-2 [KO:K06087]
118309861  cldn19; claudin-19 isoform X1 [KO:K06087]
118300246  putative claudin-24 [KO:K06087]
118300583  cldn29; claudin 29 [KO:K06087]
118300584  claudin-4 isoform X1 [KO:K06087]
118300585  claudin-like protein ZF-A89 [KO:K06087]
118300586  claudin-4-like [KO:K06087]
118310520  cldn10a; claudin-10a [KO:K06087]
118282505  claudin-14 [KO:K06087]
118282590  claudin-10 isoform X1 [KO:K06087]
118282591  claudin-10 isoform X1 [KO:K06087]
118282593  claudin-10-like isoform X3 [KO:K06087]
118300737  claudin-7-B [KO:K06087]
118310856  cldn15la; claudin 15-like a [KO:K06087]
118317058  claudin-34-like isoform X1 [KO:K06087]
118288740  cldnk; claudin k [KO:K06087]
118288817  cldni; claudin i [KO:K06087]
118311502  cldn1; claudin-1 [KO:K06087]
118317713  claudin-1 [KO:K06087]
118317794  claudin-18 isoform X1 [KO:K06087]
118318027  cldn34a; claudin-34 [KO:K06087]
118318715  putative claudin-24 [KO:K06087]
118301055  cldn7a; claudin-7-A [KO:K06087]
118301121  cldn12; claudin-12 [KO:K06087]
118284745  cldn23.1; claudin 23a [KO:K06087]
118301333  cldn5b; claudin-5b [KO:K06087]
118313118  claudin-9-like [KO:K06087]
118285743  cldn23l; claudin-23 [KO:K06087]
118291309  claudin-11-like [KO:K06087]
118291377  cldn15a; claudin-15a [KO:K06087]
118313864  cldn26; putative claudin-24 [KO:K06087]
118313908  cldn5a; claudin 5a [KO:K06087]
118285858  cldn11a; claudin-11a [KO:K06087]
118300587  claudin-4 [KO:K06087]
118290002  claudin-20-like [KO:K06087]
118286414  claudin-20 [KO:K06087]
118292222  cldn35; claudin-4 [KO:K06087]
118305245  cldn10e; claudin-10 [KO:K06087]
118305261  claudin-10 [KO:K06087]
118305277  claudin-10-like [KO:K06087]
118310968  cldn18; claudin-18 [KO:K06087]
118294753  cldn8.2; claudin-8 [KO:K06087]
118294769  cldn8.1; claudin-8 [KO:K06087]
118294785  claudin-4 [KO:K06087]
118298802  claudin-1 [KO:K06087]
118299110  claudin-9-like [KO:K06087]
118299221  claudin-4 [KO:K06087]
118299222  claudin-4-like [KO:K06087]
118299224  cldnj; claudin j [KO:K06087]
118299225  claudin-4 [KO:K06087]
118299226  cldne; claudin e [KO:K06087]
118299228  cldnf; claudin f [KO:K06087]
118318049  si:ch73-61d6.3; occludin isoform X1 [KO:K06088]
118301283  oclna; occludin [KO:K06088]
118300461  f11r.1; F11 receptor, tandem duplicate 1 [KO:K06089]
118300944  jam2a; junctional adhesion molecule 2A isoform X1 [KO:K06735]
118282874  jam2b; junctional adhesion molecule 2b isoform X1 [KO:K06735]
118299813  jam3a; junctional adhesion molecule 3B [KO:K06785]
118300922  jam3b; junctional adhesion molecule 3B isoform X1 [KO:K06785]
118301061  esama; endothelial cell adhesion molecule a [KO:K06787]
118299135  esamb; endothelial cell-selective adhesion molecule isoform X1 [KO:K06787]
118283835  cdh5; cadherin-5 [KO:K06533]
118288996  pecam1a; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
118312726  pecam1b; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
118311989  cd99; CD99 molecule isoform X1 [KO:K06520]
118313738  cd99l2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
118287144  integrin alpha-M isoform X1 [KO:K06461]
118317871  P-selectin isoform X2 [KO:K06496]
118282930  itga4; integrin alpha-4 [KO:K06483]
118291086  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
118283311  itga9; integrin alpha-9 [KO:K06585]
118317775  vcam1b; vascular cell adhesion protein 1b [KO:K06527]
118317870  E-selectin-like isoform X1 [KO:K06495]
118317321  cd34; uncharacterized protein cd34 [KO:K06474]
118309121  si:ch211-286o17.1; uncharacterized protein si:ch211-286o17.1 [KO:K06474]
118302839  Golgi apparatus protein 1-like isoform X1 [KO:K06816]
118314878  glg1a; Golgi apparatus protein 1 isoform X1 [KO:K06816]
118317868  E-selectin isoform X1 [KO:K06494]
118282634  si:ch211-214p13.3; nectin-1 isoform X1 [KO:K06081]
118301493  nectin-1-like isoform X2 [KO:K06081]
118299202  nectin1b; nectin cell adhesion molecule 1b isoform X4 [KO:K06081]
118311202  cdh2; cadherin-2 [KO:K06736]
118300902  ncam1a; neural cell adhesion molecule 1a isoform X4 [KO:K06491]
118312164  neural cell adhesion molecule 2-like isoform X1 [KO:K06491]
118313102  ncam3; neural cell adhesion molecule 1 isoform X2 [KO:K06491]
118299197  ncam1b; neural cell adhesion molecule 1b isoform X5 [KO:K06491]
118316290  l1cama; neural cell adhesion molecule L1.2 isoform X1 [KO:K06550]
118317358  neural cell adhesion molecule L1.1-like isoform X1 [KO:K06550]
118300611  cadm1a; cell adhesion molecule 1a isoform X1 [KO:K06781]
118299198  cadm1b; cell adhesion molecule 1b isoform X1 [KO:K06781]
118318409  negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
118311462  netrin-G1-like isoform X1 [KO:K07522]
118291139  ntng1a; netrin-G1 isoform X1 [KO:K07522]
118315771  lrrc4ca; leucine rich repeat containing 4C, genome duplicate a [KO:K07523]
118302818  lrrc4cb; leucine-rich repeat-containing protein 4C [KO:K07523]
118285395  ntng2b; netrin-G2 [KO:K16359]
118314011  netrin-G2 isoform X3 [KO:K16359]
118318564  lrrc4.1; leucine-rich repeat-containing protein 4 [KO:K16351]
118315499  lrrc4.2; leucine-rich repeat-containing protein 4.2 [KO:K16351]
118310337  ptprfb; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
118318237  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
118287946  lrrc4bb; leucine-rich repeat-containing protein 4B [KO:K16360]
118289464  lrrc4ba; leucine-rich repeat-containing protein 4B [KO:K16360]
118292162  sdc2; syndecan-2 [KO:K16336]
118307309  syndecan-2 [KO:K16336]
118292168  sdc3; syndecan-3 [KO:K16337]
118309347  sdc4; syndecan-4 isoform X1 [KO:K16338]
118320435  itgav; integrin alpha-V [KO:K06487]
118291677  itgb8; integrin beta-8 isoform X1 [KO:K06591]
118302043  itga8; integrin alpha-8 [KO:K06584]
118287677  nrxn1a; neurexin 1a isoform X1 [KO:K07377]
118300857  nrxn2b; neurexin 2b isoform X2 [KO:K07377]
118283604  neurexin-1a isoform X1 [KO:K07377]
118286342  nrxn3a; neurexin 3a isoform X1 [KO:K07377]
118300404  nlgn3b; neuroligin-3b isoform X1 [KO:K07378]
118282938  neuroligin-4, X-linked-like [KO:K07378]
118318645  nlgn1; neuroligin-1 [KO:K07378]
118301406  nlgn2a; neuroligin-2a isoform X1 [KO:K07378]
118313165  nlgn4xa; neuroligin 4 X-linked a [KO:K07378]
118319712  nlgn3a; neuroligin-3a isoform X1 [KO:K07378]
118301086  nlgn2b; neuroligin-2b [KO:K07378]
118311196  receptor-type tyrosine-protein phosphatase S-like isoform X1 [KO:K06778] [EC:3.1.3.48]
118317967  ptprsa; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
118314005  SLIT and NTRK-like protein 1 [KO:K25832]
118319862  slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
118319843  slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]
118315866  SLIT and NTRK-like protein 5 [KO:K25836]
118282774  slitrk5b; SLIT and NTRK-like protein 5 [KO:K25836]
118313982  slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
118282529  receptor-type tyrosine-protein phosphatase delta-like isoform X4 [KO:K06777] [EC:3.1.3.48]
118312831  ptprdb; protein tyrosine phosphatase receptor type Db isoform X1 [KO:K06777] [EC:3.1.3.48]
118299723  slitrk3a; SLIT and NTRK-like protein 3 [KO:K25834]
118285790  SLIT and NTRK-like protein 3 [KO:K25834]
118310493  cadm3; cell adhesion molecule 3 isoform X3 [KO:K06780]
118285742  nrcama; neuronal cell adhesion molecule a isoform X1 [KO:K06756]
118315013  neuronal cell adhesion molecule-like isoform X1 [KO:K06756]
118285807  cntn1b; contactin 1b isoform X1 [KO:K06759]
118315527  contactin-1a-like isoform X1 [KO:K06759]
118311348  receptor-type tyrosine-protein phosphatase mu-like isoform X1 [KO:K05693] [EC:3.1.3.48]
118290961  receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
118309674  cntn2; contactin-2 [KO:K06760]
118316994  nfascb; neurofascin [KO:K06757]
118309157  nfasca; neurofascin homolog (chicken) a isoform X1 [KO:K06757]
118288456  cntnap1; contactin-associated protein 1 [KO:K07379]
118310637  cntnap2b; contactin-associated protein-like 2b isoform X2 [KO:K07380]
118291463  cntnap2a; contactin-associated protein-like 2a isoform X2 [KO:K07380]
118310995  mpz; myelin protein P0 isoform X2 [KO:K06770]
118300503  myelin-associated glycoprotein isoform X1 [KO:K06771]
118313761  myelin-associated glycoprotein isoform X1 [KO:K06771]
118315912  B-cadherin-like isoform X1 [KO:K05689]
118283500  cadherin-1 [KO:K05689]
118283039  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
118311752  itga6b; integrin alpha-6b isoform X1 [KO:K06485]
118319755  integrin alpha-6 [KO:K06485]
118309853  cadherin-4 isoform X1 [KO:K06797]
118316962  cadherin-4-like isoform X1 [KO:K06797]
118302338  cdh15; cadherin-15 [KO:K06809]
118302157  neo1a; neogenin 1a isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
smau04520  Adherens junction
smau04530  Tight junction
KO pathway
ko04514   
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