Entry
Name
Spliceosome - Triplophysa dalaica
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Triplophysa dalaica [GN:
tdw ]
Gene
130438476 slu7; LOW QUALITY PROTEIN: pre-mRNA-splicing factor SLU7 [KO:K12819 ]
130424736 snrpb; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086 ]
130408090 snrpd3l; small nuclear ribonucleoprotein D3 polypeptide, like [KO:K11088 ]
130438355 tcerg1a; transcription elongation regulator 1a isoform X1 [KO:K12824 ]
130407320 sf3a1; LOW QUALITY PROTEIN: splicing factor 3A subunit 1 [KO:K12825 ]
130428019 u2af1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836 ]
130433489 u2af2a; U2 small nuclear RNA auxiliary factor 2a isoform X1 [KO:K12837 ]
130417297 puf60a; poly(U)-binding-splicing factor PUF60a isoform X1 [KO:K12838 ]
130417793 puf60b; poly(U)-binding-splicing factor PUF60-B isoform X1 [KO:K12838 ]
130436649 smndc1; survival of motor neuron-related-splicing factor 30 [KO:K12839 ]
130430057 cherp; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841 ]
130417285 u2surp; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842 ]
130419248 zgc:163098; U2 snRNP-associated SURP motif-containing protein [KO:K12842 ]
130430800 lsm7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626 ]
130425661 snu13a; SNU13 homolog, small nuclear ribonucleoprotein a (U4/U6.U5) [KO:K12845 ]
130439351 snu13b; SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5) [KO:K12845 ]
130419365 snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
130407573 sart1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984 ]
130426028 eftud2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
130415612 snrnp40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
130440299 hspa1b; LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283 ]
130428391 hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283 ]
130417201 acin1a; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875 ]
130409234 hnrnpa1b; heterogeneous nuclear ribonucleoprotein A1b [KO:K12741 ]
130427173 hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
130410143 hnrnpa1a; heterogeneous nuclear ribonucleoprotein A1a [KO:K12741 ]
130417230 hnrnpc; heterogeneous nuclear ribonucleoproteins C1/C2 [KO:K12884 ]
130420003 hnrpkl; heterogeneous nuclear ribonucleoprotein K, like isoform X1 [KO:K12886 ]
130440386 hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
130430343 hnrnpm; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
130437214 hnrnpua; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
130434341 hnrnpub; heterogeneous nuclear ribonucleoprotein Ub isoform X1 [KO:K12888 ]
130431227 srsf5a; serine and arginine rich splicing factor 5a isoform X1 [KO:K12893 ]
130410406 serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896 ]
130419297 srsf7a; serine and arginine rich splicing factor 7a isoform X1 [KO:K12896 ]
130416007 tra2a; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
130415437 serine/arginine-rich splicing factor 10-like isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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