KEGG   PATHWAY: vvp00230
Entry
vvp00230                    Pathway                                
Name
Purine metabolism - Vulpes vulpes (red fox)
Class
Metabolism; Nucleotide metabolism
Pathway map
vvp00230  Purine metabolism
vvp00230

Module
vvp_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:vvp00230]
vvp_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:vvp00230]
vvp_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:vvp00230]
vvp_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:vvp00230]
vvp_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:vvp00230]
vvp_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:vvp00230]
vvp_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:vvp00230]
Other DBs
GO: 0006163 0042278
Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112919664  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
112924903  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
112933374  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
112926066  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
112919204  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
112915815  PRPS1L1; LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
112932388  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
112932027  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
112923710  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
112909277  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
112924876  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
112923709  uncharacterized protein LOC112923709 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
112934035  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
112922580  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
112924547  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
112908202  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
112920781  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
112924969  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
112932132  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
112915593  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
112926432  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
112914844  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
112933917  LACC1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
112927879  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
112907865  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
112928904  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
112911784  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
112912156  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
112917880  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
112917881  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
112909096  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
112923489  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
112925166  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
112921630  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
112914147  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
112911431  ENTPD8; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
112926807  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
112933230  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
112927264  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
112930096  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
112933009  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112927541  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
112925401  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
112926548  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
112920527  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
112922106  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
112911971  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
112928709  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
112927720  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
112916984  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
112930931  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
112916732  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
112923681  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
112921522  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
112907687  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
112911455  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112934273  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112908545  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112926558  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
112913504  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112921089  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112929565  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112915982  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112923266  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112914158  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
112923501  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
112925911  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
112933458  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
112933413  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
112910844  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
112917486  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
112924739  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
112928727  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
112932078  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
112914554  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
112918863  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
112930835  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
112911290  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
112935413  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
112934859  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
112928681  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
112917482  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
112926998  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
112930974  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
112928761  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
112918680  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
112913921  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
112925456  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
112920894  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
112917256  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13760]
112907998  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
112932957  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
112916550  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
112930306  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
112923534  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
112927068  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
112916827  AMPD1; LOW QUALITY PROTEIN: AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
112918270  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
112924649  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
112920078  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
112917432  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
112927915  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
112911845  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
112907921  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
112928003  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
112924460  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
112930239  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
112931743  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
112908199  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
112918386  adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
112922146  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
112910958  GTP:AMP phosphotransferase AK3, mitochondrial-like isoform X1 [KO:K00944] [EC:2.7.4.10]
112932420  GTP:AMP phosphotransferase AK3, mitochondrial-like isoform X1 [KO:K00944] [EC:2.7.4.10]
112912730  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
112927347  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
112912249  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
112913792  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
112908189  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
112935316  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
112913090  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
112907877  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
112919460  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
112929823  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
112921341  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
112919739  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
112909469  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
112914045  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
112931985  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
112934193  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
112924412  uricase isoform X1 [KO:K00365] [EC:1.7.3.3]
112927787  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
vvp00030  Pentose phosphate pathway
vvp00220  Arginine biosynthesis
vvp00250  Alanine, aspartate and glutamate metabolism
vvp00260  Glycine, serine and threonine metabolism
vvp00340  Histidine metabolism
vvp00630  Glyoxylate and dicarboxylate metabolism
vvp00730  Thiamine metabolism
vvp00740  Riboflavin metabolism
vvp00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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