KEGG   PATHWAY: vvp04714
Entry
vvp04714                    Pathway                                
Name
Thermogenesis - Vulpes vulpes (red fox)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
vvp04714  Thermogenesis
vvp04714

Other DBs
GO: 1990845
Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112916126  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
112932168  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112932169  neuroendocrine secretory protein 55 [KO:K04632]
112911455  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112934273  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112908545  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112926558  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
112913504  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112921089  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
112929565  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112915982  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112923266  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112914158  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
112923501  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
112908063  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112924478  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112922611  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112930843  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
112918871  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
112924095  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
112935546  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
112908881  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
112915694  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
112924714  PRDM16; PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
112919335  ZNF516; zinc finger protein 516 isoform X1 [KO:K22411]
112930162  KDM1A; lysine-specific histone demethylase 1A [KO:K11450] [EC:1.14.99.66]
112934939  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
112921904  KDM3B; lysine-specific demethylase 3B [KO:K15601] [EC:1.14.11.65]
112916661  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
112908164  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
112922132  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
112907555  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
112922388  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
112908749  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
112916248  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
112920709  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
112921128  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
112917760  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
112920888  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
112929326  ACTB; LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
112926222  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
112935668  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
112931792  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
112935151  ARID1B; LOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 1B [KO:K11653]
112927240  DPF3; zinc finger protein DPF3 [KO:K22198]
112928426  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
112933683  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
112919386  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
112924977  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112913931  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112913932  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
112935862  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112935863  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112918943  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
112916383  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
112935584  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
112931222  FGF21; fibroblast growth factor 21 [KO:K22429]
112922976  PLIN1; perilipin-1 [KO:K08768]
112931218  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
112924122  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
112914482  MGLL; monoglyceride lipase [KO:K01054] [EC:3.1.1.23]
112933502  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
112926098  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112907666  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
112932888  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
112916245  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
112922478  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
112921100  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112916532  GCG; glucagon [KO:K05259]
112908263  bone morphogenetic protein 8B-like [KO:K16622]
112908382  CNR1; cannabinoid receptor 1 [KO:K04277]
112929727  NPPA; natriuretic peptides A [KO:K12334]
112929693  NPPB; natriuretic peptides B [KO:K12335]
112918863  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
112931969  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
112919705  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
112919342  KLB; beta-klotho [KO:K22404]
112916136  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112922278  FRS2; fibroblast growth factor receptor substrate 2 isoform X1 [KO:K12461]
112920790  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112921310  SOS2; son of sevenless homolog 2 [KO:K03099]
112935267  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112914428  HRAS; GTPase HRas isoform X1 [KO:K02833]
112917213  KRAS; GTPase KRas isoform X1 [KO:K07827]
112916766  NRAS; GTPase NRas [KO:K07828]
112919120  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
112931755  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
112932959  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
112933571  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
112928006  TSC1; hamartin isoform X1 [KO:K07206]
112909041  TSC2; tuberin isoform X1 [KO:K07207]
112916202  RHEB; GTP-binding protein Rheb [KO:K07208]
112920880  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
112929738  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112908983  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
112931404  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
112917940  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112924182  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
112925882  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
112922008  RPS6; 40S ribosomal protein S6 [KO:K02991]
112922500  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
112916119  ACSL5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
112917090  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
112932002  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
112934793  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
4355757  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4355758  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4355759  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4355760  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4355761  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4355762  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4355763  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
112922840  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
112910060  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
112924059  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
112933775  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
112914646  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
112935439  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
112935521  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
112924170  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
112924173  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
112925281  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
112908003  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
112921285  LOW QUALITY PROTEIN: protein AF-9-like [KO:K03944]
112910581  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112930992  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
112934215  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
112909425  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
112926594  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112922356  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1 [KO:K03948]
112923930  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
112935100  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
112935298  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
112933985  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
112909652  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
112927842  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
112917371  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
112908750  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
112908301  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
112911844  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
112930692  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
112912796  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
112909583  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112921738  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
112906994  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
112922878  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
112913474  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
112926224  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
112927561  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
112908162  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
112914900  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
112915972  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
112909101  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
112907284  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
112931904  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
112928610  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
112919969  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
112935419  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
112911821  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
112923137  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
112922747  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
112931258  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
112935305  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
112920884  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 isoform X1 [KO:K24726]
112935451  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
112929796  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
112910067  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
112925062  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
112925986  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
112911861  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
4355756  CYTB; cytochrome b [KO:K00412]
112911146  cytochrome c1, heme protein, mitochondrial [KO:K00413]
112912006  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
112908289  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
112914767  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
112931295  cytochrome b-c1 complex subunit 7 [KO:K00417]
112917073  cytochrome b-c1 complex subunit 8 [KO:K00418]
112909861  cytochrome b-c1 complex subunit 9 [KO:K00419]
112935582  cytochrome b-c1 complex subunit 10 [KO:K00420]
4355753  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4355754  COX2; cytochrome c oxidase subunit II [KO:K02261]
4355755  COX3; cytochrome c oxidase subunit III [KO:K02262]
112909925  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
112924604  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112935489  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
112909475  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
112915186  cytochrome c oxidase subunit 5B, mitochondrial isoform X1 [KO:K02265]
112929276  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1 [KO:K02266]
112932900  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112934250  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
112909354  cytochrome c oxidase subunit 6B2 [KO:K02267]
112928325  cytochrome c oxidase subunit 6B1 [KO:K02267]
112924081  cytochrome c oxidase subunit 6B1 [KO:K02267]
112907642  cytochrome c oxidase subunit 6B1-like [KO:K02267]
112916951  cytochrome c oxidase subunit 6C [KO:K02268]
112928553  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
112916609  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
112926364  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
112909193  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
112933364  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
112917594  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112931001  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
112915513  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112924328  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
112911812  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
112923333  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
112924910  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
112917890  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
112921130  cytochrome c oxidase assembly protein COX14 [KO:K18181]
112914733  cytochrome c oxidase assembly protein COX15 homolog isoform X1 [KO:K02259] [EC:1.17.99.9]
112927223  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [KO:K18182]
112913466  cytochrome c oxidase copper chaperone [KO:K02260]
112909234  cytochrome c oxidase assembly protein COX18, mitochondrial isoform X1 [KO:K17797]
112929294  cytochrome c oxidase assembly protein COX19 isoform X1 [KO:K18183]
112923537  cytochrome c oxidase assembly protein COX20, mitochondrial isoform X1 [KO:K18184]
112925819  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
112910762  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
112928664  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
112915178  cytochrome c oxidase assembly factor 5 [KO:K18178]
112927358  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
112914712  cytochrome c oxidase assembly factor 7 [KO:K18180]
112918846  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
112922371  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
112933524  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
112907088  ATP synthase subunit delta, mitochondrial-like [KO:K02134]
112935517  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
112932252  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
112909275  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
4355751  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
112907195  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
112916561  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
112917836  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
112921187  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
112933281  ATP synthase subunit d, mitochondrial-like [KO:K02138]
112911717  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
112917673  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
112933484  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
112920787  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
4355752  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
112920349  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
112926120  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
112911902  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
112924162  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
112935810  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
112931178  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
PMID:27251423
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
PMID:24100998
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
PMID:25154875
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
PMID:26201764
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
PMID:26271143
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
PMID:26482876
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
PMID:28448947
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
PMID:24872083
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
PMID:15545214
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
PMID:20935662
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
PMID:15964803
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
PMID:27045525
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
PMID:25948511
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
PMID:25578880
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
PMID:27264172
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
PMID:27693079
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
PMID:15024092
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
PMID:21317437
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
PMID:28723567
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
PMID:27794497
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
PMID:27984203
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
PMID:29052591
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
PMID:20514071
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
PMID:25390014
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
PMID:27681418
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
PMID:22302939
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
PMID:24820868
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
PMID:22020112
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
PMID:26303601
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
PMID:28955734
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
vvp00020  Citrate cycle (TCA cycle)
vvp00190  Oxidative phosphorylation
vvp04010  MAPK signaling pathway
vvp04022  cGMP-PKG signaling pathway
vvp04024  cAMP signaling pathway
vvp04150  mTOR signaling pathway
vvp04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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