KEGG   PATHWAY: xco03440
Entry
xco03440                    Pathway                                
Name
Homologous recombination - Xiphophorus couchianus (Monterrey platyfish)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
xco03440  Homologous recombination
xco03440

Other DBs
GO: 0000724
Organism
Xiphophorus couchianus (Monterrey platyfish) [GN:xco]
Gene
114160943  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
114153478  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
114161901  mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
114142137  nbn; nibrin [KO:K10867]
114161922  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114151962  brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
114148948  bard1; BRCA1-associated RING domain protein 1 [KO:K10683]
114136741  rbbp8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
114133435  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
114137102  topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
114150162  abraxas1; BRCA1-A complex subunit Abraxas 1 isoform X1 [KO:K20774]
114152595  uimc1; BRCA1-A complex subunit RAP80 isoform X1 [KO:K20775]
114151581  babam1; BRISC and BRCA1-A complex member 1 [KO:K20776]
114134541  babam2; BRISC and BRCA1-A complex member 2 isoform X1 [KO:K12173]
114149658  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
114155338  LOW QUALITY PROTEIN: lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
114143898  palb2; partner and localizer of BRCA2 [KO:K10897]
114161835  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
114150946  sycp3; synaptonemal complex protein 3 [KO:K19528]
114133454  rpa1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
114153522  replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
114139588  rpa2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
114155489  replication protein A 32 kDa subunit-like [KO:K10739]
114155653  rpa3; replication protein A 14 kDa subunit [KO:K10740]
114158462  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
114159083  rad52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
114140480  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
114152541  rad51d; DNA repair protein RAD51 homolog 4 [KO:K10871]
114136768  xrcc2; DNA repair protein XRCC2 isoform X1 [KO:K10879]
114158972  xrcc3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
114150382  rad54l; DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
114142313  rad54b; DNA repair and recombination protein RAD54B isoform X1 [KO:K10877] [EC:5.6.2.-]
114160466  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
114154082  pold2; DNA polymerase delta subunit 2 [KO:K02328]
114147227  pold3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
114144947  pold4; DNA polymerase delta subunit 4 [KO:K03505]
114161024  blm; Bloom syndrome protein isoform X1 [KO:K10901] [EC:5.6.2.4]
114154862  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
114160058  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
114157995  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
114151909  eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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