KEGG   PATHWAY: rfq04150
Entry
rfq04150                    Pathway                                
Name
mTOR signaling pathway - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
rfq04150  mTOR signaling pathway
rfq04150

Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:rfq]
Gene
117034645  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
117030501  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
117025193  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
117036068  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117033051  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117038023  ATP6V1B2; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, brain isoform [KO:K02147]
117032899  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
117034032  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
117023472  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
117032756  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
117021067  V-type proton ATPase subunit E 1-like isoform X1 [KO:K02150]
117028887  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
117018272  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
117032408  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
117018613  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
117020879  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
117033947  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117030245  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
117015383  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
117023779  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR2-like [KO:K20398]
117022406  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117037116  ragulator complex protein LAMTOR3-like [KO:K04370]
117024836  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
117014251  LAMTOR5; ragulator complex protein LAMTOR5 isoform X1 [KO:K16344]
117013273  FLCN; folliculin isoform X1 [KO:K09594]
117016740  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
117037834  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
117027006  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
117031867  RRAGA; ras-related GTP-binding protein A [KO:K16185]
117019032  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
117027477  RRAGC; ras-related GTP-binding protein C [KO:K16186]
117027265  SESN2; sestrin-2 [KO:K20394]
117017246  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
117024717  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
117012451  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
117011831  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
117019795  WDR24; GATOR complex protein WDR24 [KO:K20408]
117035225  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
117025311  protein SEC13 homolog [KO:K14004]
117037010  SEC13; protein SEC13 homolog [KO:K14004]
117017444  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
117037213  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
117019442  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
117025370  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
117011701  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
117012918  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117034482  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
117026614  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117033902  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
117019556  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
117019418  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
117016332  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
117017319  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
117012293  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
117032949  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
117011763  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
117015837  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
117017538  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
117013180  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
117021620  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
117025830  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
117022153  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
117036900  eukaryotic translation initiation factor 4E-like [KO:K03259]
117016787  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
117013759  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117029822  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
117028513  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
117032305  RPS6; 40S ribosomal protein S6 [KO:K02991]
117025836  40S ribosomal protein S6-like [KO:K02991]
117021695  40S ribosomal protein S6-like [KO:K02991]
117030712  40S ribosomal protein S6-like [KO:K02991]
117030948  40S ribosomal protein S6-like [KO:K02991]
117017028  40S ribosomal protein S6-like [KO:K02991]
117013392  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
117026261  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
117038062  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117025899  CAB39; calcium-binding protein 39 [KO:K08272]
117021805  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
117027298  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
117024471  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117031806  TSC1; hamartin isoform X1 [KO:K07206]
117019487  TSC2; tuberin isoform X1 [KO:K07207]
117027446  TBC1 domain family member 7 [KO:K20396]
117018188  RHEB; GTP-binding protein Rheb [KO:K07208]
117036399  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
117029017  WNT1; proto-oncogene Wnt-1 [KO:K03209]
117018023  WNT2; protein Wnt-2 [KO:K00182]
117014521  WNT2B; protein Wnt-2b [KO:K00182]
117012677  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
117016493  WNT3A; protein Wnt-3a [KO:K00312]
117027735  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
117028968  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
117037227  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
117025515  WNT6; protein Wnt-6 [KO:K00445]
117028089  WNT7B; LOW QUALITY PROTEIN: protein Wnt-7b [KO:K00572]
117037159  WNT7A; protein Wnt-7a [KO:K00572]
117036140  WNT8B; protein Wnt-8b [KO:K00714]
117016938  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
117013580  WNT9B; protein Wnt-9b [KO:K01064]
117016490  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
117025971  WNT10A; protein Wnt-10a [KO:K01357]
117028646  WNT10B; protein Wnt-10b [KO:K01357]
117029800  WNT11; protein Wnt-11 [KO:K01384]
117018171  WNT16; protein Wnt-16 [KO:K01558]
117026052  FZD7; frizzled-7 [KO:K02432]
117012412  FZD1; frizzled-1 [KO:K02432]
117012665  FZD2; frizzled-2 [KO:K02235]
117038134  FZD3; frizzled-3 isoform X1 [KO:K02329]
117030191  FZD4; frizzled-4 [KO:K02354]
117025650  FZD5; frizzled-5 [KO:K02375]
117022457  FZD8; frizzled-8 [KO:K02375]
117034048  FZD6; frizzled-6 [KO:K02376]
117024449  FZD9; frizzled-9 isoform X1 [KO:K02842]
117017256  FZD10; frizzled-10 [KO:K02842]
117028415  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
117029906  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
117026749  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
117012844  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
117037434  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
117033539  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117020338  TNF; tumor necrosis factor [KO:K03156]
117028184  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117021384  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117030020  INS; insulin [KO:K04526]
117028523  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117037841  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117018797  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117013296  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117032869  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117022939  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117013636  GTPase HRas-like [KO:K02833]
117029835  HRAS; LOW QUALITY PROTEIN: GTPase HRas [KO:K02833]
117028978  KRAS; GTPase KRas isoform X1 [KO:K07827]
117014672  NRAS; GTPase NRas [KO:K07828]
117018062  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117037259  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117022968  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117037633  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117017296  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117019062  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117026980  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117021692  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117022043  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117025871  IRS1; insulin receptor substrate 1 [KO:K16172]
117027160  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117024531  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117038261  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117027443  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117035064  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117037029  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117035771  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117019434  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
117018458  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117035083  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117023560  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117036177  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117032119  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
117024729  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
117028528  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
117030839  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
117036663  RHOA; transforming protein RhoA [KO:K04513]
117012818  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117019414  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117035150  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117019130  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
rfq00561  Glycerolipid metabolism
rfq04010  MAPK signaling pathway
rfq04140  Autophagy - animal
rfq04151  PI3K-Akt signaling pathway
rfq04152  AMPK signaling pathway
rfq04810  Regulation of actin cytoskeleton
rfq04910  Insulin signaling pathway
KO pathway
ko04150   
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