KEGG   PATHWAY: rfq04151
Entry
rfq04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
rfq04151  PI3K-Akt signaling pathway
rfq04151

Other DBs
GO: 0043491
Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:rfq]
Gene
117021897  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117033382  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117021895  EREG; proepiregulin [KO:K09784]
117022312  AREG; amphiregulin [KO:K09782]
117016625  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117037862  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
117025364  FGF10; fibroblast growth factor 10 [KO:K04358]
117027635  FGF16; fibroblast growth factor 16 [KO:K04358]
117021496  FGF20; fibroblast growth factor 20 [KO:K04358]
117021758  FGF9; fibroblast growth factor 9 [KO:K04358]
117028974  FGF6; fibroblast growth factor 6 [KO:K04358]
117022308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
117036181  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117030196  FGF3; fibroblast growth factor 3 [KO:K04358]
117030198  FGF4; fibroblast growth factor 4 [KO:K04358]
117023393  FGF7; fibroblast growth factor 7 [KO:K04358]
117016767  FGF18; fibroblast growth factor 18 [KO:K04358]
117038202  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117038267  FGF22; fibroblast growth factor 22 [KO:K04358]
117030197  FGF19; fibroblast growth factor 19 [KO:K22603]
117035017  FGF21; fibroblast growth factor 21 [KO:K22429]
117028661  FGF23; fibroblast growth factor 23 [KO:K22428]
117014821  NGF; beta-nerve growth factor [KO:K02582]
117029758  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
117028672  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
117035029  NTF4; neurotrophin-4 [KO:K12457]
117030020  INS; insulin [KO:K04526]
117028523  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117030019  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
117016876  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117029043  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117031167  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117038535  PDGFC; platelet-derived growth factor C [KO:K05450]
117014994  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117029147  KITLG; kit ligand isoform X1 [KO:K05461]
117034353  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
117016780  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117031344  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
117022809  PGF; placenta growth factor isoform X1 [KO:K16859]
117025800  VEGFD; vascular endothelial growth factor D [KO:K05449]
117021086  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
117012542  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117034118  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
117021387  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
117015886  ANGPT4; angiopoietin-4 [KO:K05467]
117014273  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
117014777  EFNA1; ephrin-A1 [KO:K05462]
117014844  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
117038068  ephrin-A2 isoform X1 [KO:K05462]
117025140  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
117024944  GDNF; LOW QUALITY PROTEIN: glial cell line-derived neurotrophic factor [KO:K05452]
117037472  NRTN; neurturin [KO:K25414]
117026556  ARTN; artemin [KO:K25415]
117037413  PSPN; persephin [KO:K25416]
117012187  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117013264  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117028913  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
117026370  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117021283  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117035827  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117022243  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117017069  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117013914  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117014296  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117032168  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117037841  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117018797  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117022011  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117016666  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117016537  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117022389  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
117021070  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117026978  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117021297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117016973  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117022432  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117018153  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117032285  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
117027437  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117036190  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117013296  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117032869  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117022939  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117013636  GTPase HRas-like [KO:K02833]
117029835  HRAS; LOW QUALITY PROTEIN: GTPase HRas [KO:K02833]
117028978  KRAS; GTPase KRas isoform X1 [KO:K07827]
117014672  NRAS; GTPase NRas [KO:K07828]
117037259  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117022968  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117037633  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117017296  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117025871  IRS1; insulin receptor substrate 1 [KO:K16172]
117037546  TLR2; toll-like receptor 2 [KO:K10159]
117032253  TLR4; toll-like receptor 4 [KO:K10160]
117016447  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117024085  uncharacterized protein LOC117024085 [KO:K06856]
117031968  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
117019374  CD19; B-lymphocyte antigen CD19 [KO:K06465]
117036124  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
117013902  somatotropin [KO:K05438]
117027368  PRL; prolactin isoform X1 [KO:K05439]
117017261  OSM; oncostatin-M [KO:K05418]
117038186  IL2; interleukin-2 [KO:K05429]
117017055  interleukin-3-like [KO:K04736]
117012414  IL6; interleukin-6 [KO:K05405]
117017057  IL4; interleukin-4 [KO:K05430]
117033967  IL7; interleukin-7 isoform X1 [KO:K05431]
117032089  interferon alpha-4-like [KO:K05414]
117032090  interferon alpha-4-like [KO:K05414]
117032413  IFNB1; interferon beta [KO:K05415]
117024646  EPO; erythropoietin [KO:K05437]
117013664  CSF3; granulocyte colony-stimulating factor [KO:K05423]
117024708  GHR; LOW QUALITY PROTEIN: growth hormone receptor [KO:K05080]
117024874  PRLR; prolactin receptor [KO:K05081]
117025195  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
117019205  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
117029472  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
117024055  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
117029540  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
117014426  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
117019653  IL4R; LOW QUALITY PROTEIN: interleukin-4 receptor subunit alpha [KO:K05071]
117025154  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
117035219  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
117036856  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
117037466  EPOR; erythropoietin receptor [KO:K05079]
117027656  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
117026596  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
117031937  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
117038244  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
117012341  COL1A2; collagen alpha-2(I) chain [KO:K06236]
117013537  COL1A1; collagen alpha-1(I) chain [KO:K06236]
117029195  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
117025810  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
117025811  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
117026250  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
117021788  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
117021789  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
117022417  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
117025867  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
117033836  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
117036050  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
117036561  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
117036601  collagen alpha-4(VI) chain-like [KO:K06238]
117036692  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
117027687  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
117020788  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
117015661  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
117011961  LAMA1; laminin subunit alpha-1 [KO:K05637]
117020214  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
117011881  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
117015825  LAMA5; laminin subunit alpha-5 [KO:K06240]
117020550  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
117012166  LAMB1; laminin subunit beta-1 [KO:K05636]
117036648  laminin subunit beta-2 isoform X1 [KO:K06243]
117037112  laminin subunit beta-2-like [KO:K06243]
117014604  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
117012110  LAMB4; laminin subunit beta-4 [KO:K06245]
117014660  LAMC1; laminin subunit gamma-1 [KO:K05635]
117014266  LAMC2; laminin subunit gamma-2 [KO:K06246]
117032321  LAMC3; laminin subunit gamma-3 [KO:K06247]
117013018  CHAD; chondroadherin [KO:K06248]
117012170  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
117023582  THBS1; thrombospondin-1 [KO:K16857]
117025357  THBS4; thrombospondin-4 [KO:K04659]
117019072  THBS2; thrombospondin-2 [KO:K04659]
117015102  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
117037894  COMP; cartilage oligomeric matrix protein [KO:K04659]
117026176  FN1; fibronectin isoform X1 [KO:K05717]
117021999  SPP1; osteopontin isoform X1 [KO:K06250]
117012681  VTN; vitronectin [KO:K06251]
117032123  TNC; tenascin isoform X1 [KO:K06252]
117014329  TNR; tenascin-R isoform X1 [KO:K06252]
117014867  TNN; tenascin-N isoform X1 [KO:K06252]
117016487  TNXB; tenascin-X [KO:K06252]
117028289  VWF; von Willebrand factor [KO:K03900]
117022282  IBSP; bone sialoprotein 2 [KO:K06253]
117025342  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
117025275  ITGA2; integrin alpha-2 [KO:K06481]
117012624  ITGA2B; integrin alpha-IIb [KO:K06476]
117013450  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
117025777  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
117028364  ITGA5; integrin alpha-5 [KO:K06484]
117026132  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
117028729  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
117019175  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
117037011  ITGA9; integrin alpha-9 [KO:K06585]
117014895  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
117024225  ITGA11; integrin alpha-11 [KO:K06587]
117025896  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
117022297  ITGB1; LOW QUALITY PROTEIN: integrin beta-1 [KO:K05719]
117013435  ITGB3; integrin beta-3 [KO:K06493]
117013084  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
117035495  ITGB5; integrin beta-5 [KO:K06588]
117025444  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
117029392  ITGB7; integrin beta-7 [KO:K06590]
117012361  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
117033640  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117027443  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117035064  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117037029  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117027160  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117024531  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117038261  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117025288  F2R; proteinase-activated receptor 1 [KO:K03914]
117030679  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
117018247  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
117032311  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
117037446  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
117026509  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
117025847  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
117029393  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
117021435  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
117026721  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
117025270  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
117028938  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
117014467  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
117023601  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
117023859  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
117030010  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
117018688  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
117026503  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
117013994  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
117037607  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
117035136  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
117032086  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
117012111  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
117027381  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117038030  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
117019395  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
117012455  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
117013107  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
117012427  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
117012707  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
117013842  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
117019434  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
117038062  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117027298  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
117024471  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
117036399  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
117031806  TSC1; hamartin isoform X1 [KO:K07206]
117019487  TSC2; tuberin isoform X1 [KO:K07207]
117018188  RHEB; GTP-binding protein Rheb [KO:K07208]
117019556  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
117026614  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117012918  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
117021620  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
117025830  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
117022153  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
117036900  eukaryotic translation initiation factor 4E-like [KO:K03259]
117016787  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
117013759  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117029822  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
117028513  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
117032305  RPS6; 40S ribosomal protein S6 [KO:K02991]
117025836  40S ribosomal protein S6-like [KO:K02991]
117021695  40S ribosomal protein S6-like [KO:K02991]
117030712  40S ribosomal protein S6-like [KO:K02991]
117030948  40S ribosomal protein S6-like [KO:K02991]
117017028  40S ribosomal protein S6-like [KO:K02991]
117012818  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117038387  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
117027165  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
117031721  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
117019130  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
117015675  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
117033805  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
117018458  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117035083  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117023560  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117036734  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
117012347  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
117035771  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117019794  LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
117015148  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
117021745  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
117016687  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
117034671  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
117030068  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
117035815  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
117022414  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
117038009  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
117016963  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
117027307  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
117022915  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
117037114  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
117020780  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
117014370  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
117023415  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
117031017  PPP2R5B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
117024152  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
117017906  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
117036086  heat shock protein HSP 90-alpha-like [KO:K04079]
117023049  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
117023744  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
117028695  HSP90B1; endoplasmin [KO:K09487]
117037961  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
117014506  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
117011819  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
117034489  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
117022822  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
117028137  MTCP1; protein p13 MTCP-1 [KO:K16837]
117018217  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
117013957  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
117033539  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117034562  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
117028906  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
117022899  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
117016071  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
117026232  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
117012927  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
117013788  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
117034063  MYC; myc proto-oncogene protein [KO:K04377]
117030194  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
117020319  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
117029064  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
117029388  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
117029166  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
117012188  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
117028515  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
117017078  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
117033712  CCNE2; LOW QUALITY PROTEIN: G1/S-specific cyclin-E2 [KO:K06626]
117034270  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
117019600  FOXO3; forkhead box protein O3 [KO:K09408]
117034416  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
117014309  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117019288  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
117033201  YWHAQ; 14-3-3 protein theta [KO:K16197]
117033560  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
117015612  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
117013260  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
117017534  YWHAH; 14-3-3 protein eta [KO:K16198]
117024800  YWHAG; 14-3-3 protein gamma [KO:K16198]
117030073  BAD; bcl2-associated agonist of cell death [KO:K02158]
117015788  BCL2L1; bcl-2-like protein 1 [KO:K04570]
117011845  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
117027311  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
117025697  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
117025773  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117028134  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117018063  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
117015251  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
117037901  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
117031331  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
117031476  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
117012438  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117016491  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
117014629  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
117031706  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
117029230  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
117020791  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117036177  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117021384  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117030742  RELA; transcription factor p65 isoform X1 [KO:K04735]
117022439  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117020543  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
117033422  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117029053  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117013763  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
rfq00010  Glycolysis / Gluconeogenesis
rfq04010  MAPK signaling pathway
rfq04012  ErbB signaling pathway
rfq04062  Chemokine signaling pathway
rfq04064  NF-kappa B signaling pathway
rfq04068  FoxO signaling pathway
rfq04110  Cell cycle
rfq04115  p53 signaling pathway
rfq04150  mTOR signaling pathway
rfq04210  Apoptosis
rfq04370  VEGF signaling pathway
rfq04510  Focal adhesion
rfq04620  Toll-like receptor signaling pathway
rfq04630  JAK-STAT signaling pathway
rfq04662  B cell receptor signaling pathway
rfq04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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