KEGG   PATHWAY: rfq04010
Entry
rfq04010                    Pathway                                
Name
MAPK signaling pathway - Rhinolophus ferrumequinum (greater horseshoe bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
rfq04010  MAPK signaling pathway
rfq04010

Other DBs
GO: 0000165
Organism
Rhinolophus ferrumequinum (greater horseshoe bat) [GN:rfq]
Gene
117037598  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117032070  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
117029264  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117036785  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117014566  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
117023033  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
117012898  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117019723  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
117028679  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
117018578  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117012429  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
117037054  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
117037026  CACNA2D3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
117028875  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
117013064  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
117019144  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
117029070  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
117025859  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
117012784  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
117029304  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
117019428  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
117012671  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
117013218  CACNG5; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
117034340  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
117034891  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
117035426  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
117027001  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117037860  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117012818  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117019414  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117035150  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
117016789  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
117027381  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117038030  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
117035970  PPP3CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
117022051  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117037738  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117032505  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117033213  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
117018783  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117024869  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
117023358  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
117029919  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
117033403  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
117034648  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
117037655  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
117013151  NF1; neurofibromin isoform X1 [KO:K08052]
117024549  RASA1; ras GTPase-activating protein 1 [KO:K04352]
117036947  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
117014781  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
117028675  RAP1B; ras-related protein Rap-1b [KO:K07836]
117021897  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117033382  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117021895  EREG; proepiregulin [KO:K09784]
117022312  AREG; amphiregulin [KO:K09782]
117016625  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117037862  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
117025364  FGF10; fibroblast growth factor 10 [KO:K04358]
117027635  FGF16; fibroblast growth factor 16 [KO:K04358]
117021496  FGF20; fibroblast growth factor 20 [KO:K04358]
117021758  FGF9; fibroblast growth factor 9 [KO:K04358]
117028974  FGF6; fibroblast growth factor 6 [KO:K04358]
117022308  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
117036181  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117030196  FGF3; fibroblast growth factor 3 [KO:K04358]
117030198  FGF4; fibroblast growth factor 4 [KO:K04358]
117023393  FGF7; fibroblast growth factor 7 [KO:K04358]
117016767  FGF18; fibroblast growth factor 18 [KO:K04358]
117038202  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117038267  FGF22; fibroblast growth factor 22 [KO:K04358]
117030197  FGF19; fibroblast growth factor 19 [KO:K22603]
117035017  FGF21; fibroblast growth factor 21 [KO:K22429]
117028661  FGF23; fibroblast growth factor 23 [KO:K22428]
117014821  NGF; beta-nerve growth factor [KO:K02582]
117029758  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
117028672  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
117035029  NTF4; neurotrophin-4 [KO:K12457]
117030020  INS; insulin [KO:K04526]
117028523  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117030019  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
117016876  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117029043  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117031167  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117038535  PDGFC; platelet-derived growth factor C [KO:K05450]
117014994  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
117029147  KITLG; kit ligand isoform X1 [KO:K05461]
117034353  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
117016780  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117031344  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
117022809  PGF; placenta growth factor isoform X1 [KO:K16859]
117025800  VEGFD; vascular endothelial growth factor D [KO:K05449]
117021086  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
117012542  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117034118  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
117021387  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
117015886  ANGPT4; angiopoietin-4 [KO:K05467]
117014273  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
117014777  EFNA1; ephrin-A1 [KO:K05462]
117014844  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
117038068  ephrin-A2 isoform X1 [KO:K05462]
117025140  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
117024944  GDNF; LOW QUALITY PROTEIN: glial cell line-derived neurotrophic factor [KO:K05452]
117037472  NRTN; neurturin [KO:K25414]
117026556  ARTN; artemin [KO:K25415]
117037413  PSPN; persephin [KO:K25416]
117012187  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117013264  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
117028913  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
117026370  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
117021283  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117035827  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117022243  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117017069  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117013914  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
117014296  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117032168  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117037841  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
117018797  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117022011  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117016666  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
117016537  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
117022389  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
117021070  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
117026978  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
117021297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
117016973  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117022432  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
117018153  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
117032285  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
117027437  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
117036190  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117013296  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117032869  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117022939  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117013636  GTPase HRas-like [KO:K02833]
117029835  HRAS; LOW QUALITY PROTEIN: GTPase HRas [KO:K02833]
117028978  KRAS; GTPase KRas isoform X1 [KO:K07827]
117014672  NRAS; GTPase NRas [KO:K07828]
117034458  RRAS; ras-related protein R-Ras [KO:K07829]
117030046  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
117036845  MRAS; ras-related protein M-Ras [KO:K07831]
117022263  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117018062  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117037259  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117022968  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117037633  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117022406  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117037116  ragulator complex protein LAMTOR3-like [KO:K04370]
117017296  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117026682  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
117037741  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
117019062  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117026980  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117021692  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117022043  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117028134  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117025443  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
117014737  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
117034063  MYC; myc proto-oncogene protein [KO:K04377]
117020288  SRF; serum response factor isoform X1 [KO:K04378]
117024158  FOS; proto-oncogene c-Fos [KO:K04379]
117012835  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
117027474  STMN1; stathmin [KO:K04381]
117014282  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117022803  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
117022823  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
117023696  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
117020338  TNF; tumor necrosis factor [KO:K03156]
117019304  IL1A; interleukin-1 alpha [KO:K04383]
117019267  IL1B; interleukin-1 beta [KO:K04519]
117035087  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
117018527  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
117023034  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
117028184  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117033297  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
117036159  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
117032431  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
117015163  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
117036921  TGFBR2; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117014309  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117035725  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
117016395  CD14; monocyte differentiation antigen CD14 [KO:K04391]
117016447  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117029121  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117012711  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
117026985  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117035237  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
117021507  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117031652  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117017258  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
117036629  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
117026337  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
117028994  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
117030261  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117027839  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
117037455  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
117031496  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
117029047  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117020204  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
117038005  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
117032926  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
117032692  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
117035642  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
117031245  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
117035676  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117016094  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
117033917  STK3; serine/threonine-protein kinase 3 [KO:K04412]
117029915  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
117022645  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
117025303  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
117029931  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
117020093  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
117013390  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
117023507  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
117035063  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
117018520  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
117027960  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
117033961  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
117026184  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
117027197  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
117020789  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
117020162  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117018595  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
117012764  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
117019650  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
117017526  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
117013460  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
117037761  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
117018399  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
117013305  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
117013904  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
117030033  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
117029303  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
117019526  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
117020697  FLNA; filamin-A isoform X1 [KO:K04437]
117012945  CRK; adapter molecule crk isoform X1 [KO:K04438]
117017506  CRKL; crk-like protein [KO:K04438]
117012936  ARRB2; beta-arrestin-2 [KO:K04439]
117029970  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
117026302  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
117035933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117022220  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117016634  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117020595  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117029085  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117029232  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117016461  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117017705  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
117015230  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
117037106  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
117022924  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
117030822  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
117016166  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
117011750  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117035268  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117027175  JUN; transcription factor AP-1 [KO:K04448]
117037717  JUND; transcription factor jun-D [KO:K04449]
117025773  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117013763  TP53; cellular tumor antigen p53 [KO:K04451]
117028473  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
117022982  MAX; protein max isoform X1 [KO:K04453]
117024674  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
117024493  HSPB1; heat shock protein beta-1 [KO:K04455]
117018458  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117035083  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117023560  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117022936  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
117029198  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
117030866  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
117018484  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
117016981  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
117019270  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117028406  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117021422  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117036407  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117037194  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117030458  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
117028702  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
117025347  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
117018623  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
117012905  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
117034523  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
117032901  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
117018010  heat shock 70 kDa protein 1 [KO:K03283]
117018018  heat shock 70 kDa protein 1 [KO:K03283]
117018025  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
117018030  heat shock 70 kDa protein 1A-like [KO:K03283]
117032481  heat shock cognate 71 kDa protein-like [KO:K03283]
117019993  heat shock cognate 71 kDa protein-like [KO:K03283]
117027721  heat shock cognate 71 kDa protein-like [KO:K03283]
117017248  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
117037203  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
117023572  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
117013633  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
117029230  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
117013869  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
117036177  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
117021384  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117020791  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117013722  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
117022439  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117035904  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
117030742  RELA; transcription factor p65 isoform X1 [KO:K04735]
117035380  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
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PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
rfq04070  Phosphatidylinositol signaling system
rfq04110  Cell cycle
rfq04115  p53 signaling pathway
rfq04210  Apoptosis
rfq04310  Wnt signaling pathway
rfq04668  TNF signaling pathway
KO pathway
ko04010   
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