KEGG   PATHWAY: sasa04910
Entry
sasa04910                   Pathway                                
Name
Insulin signaling pathway - Salmo salar (Atlantic salmon)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
sasa04910  Insulin signaling pathway
sasa04910

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100136445  [KO:K07191]
100136540  [KO:K07191]
100136543  pck2; phosphoenolpyruvate carboxykinase 2 (mitochondrial) [KO:K01596] [EC:4.1.1.32]
100194533  eif4e1a; eukaryotic translation initiation factor 4e 1a [KO:K03259]
100194534  ppp1cc; protein phosphatase 1, catalytic subunit, gamma isoform [KO:K06269] [EC:3.1.3.16]
100194564  pygma; phosphorylase, glycogen (muscle) A [KO:K00688] [EC:2.4.1.1]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
100194619  fbp2; fructose-1,6-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
100194628  calm2; calmodulin 2 [KO:K02183]
100194629  CALM; calmodulin 2 (phosphorylase kinase, delta)-3 [KO:K02183]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100195007  flt2; Flotillin-2a [KO:K07192]
100195178  rheb; ras homolog enriched in brain [KO:K07208]
100195216  phkg2; phosphorylase kinase catalytic subunit gamma 2 [KO:K00871] [EC:2.7.11.19]
100195322  exoc7; exocyst complex component 7 [KO:K07195]
100195332  if4ea; Eukaryotic translation initiation factor 4E-1A [KO:K03259]
100195420  pck1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
100195725  ppr3d; phosphatase 1 regulatory subunit 3D [KO:K07189]
100195847  call4; Calmodulin-like protein 4 [KO:K02183]
100196330  aakb1; 5-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100196384  if4e2; Eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100196603  rash; GTPase HRas [KO:K02833]
100196614  flot1; flotillin 1 [KO:K07192]
100196659  ppp1cb; protein phosphatase 1, catalytic subunit, beta isoform [KO:K06269] [EC:3.1.3.16]
100196690  pp1g; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100196740  prkag1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
100286678  if4e; Eukaryotic translation initiation factor 4E [KO:K03259]
100306744  rhoq; ras homolog gene family, member Q [KO:K07194]
100306767  grb2; growth factor receptor-bound protein 2 [KO:K04364]
100306842  crk; v-crk sarcoma virus CT10 oncogene homolog (avian) [KO:K04438]
100380295  pygb; glycogen phosphorylase B [KO:K00688] [EC:2.4.1.1]
100380378  lips; Hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
100380437  rask; GTPase KRas [KO:K07827]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100380634  pp1b; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100380649  tsc1; hamartin [KO:K07206]
100380728  f16p1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
100380750  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100380849  mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
100502556  srebf1; sterol regulatory element binding transcription factor 1 [KO:K07197]
106560227  [KO:K07198] [EC:2.7.11.31]
106560337  ptprf; protein tyrosine phosphatase, receptor type F [KO:K05695] [EC:3.1.3.48]
106560362  [KO:K04440] [EC:2.7.11.24]
106560529  [KO:K02649]
106560567  [KO:K04527] [EC:2.7.10.1]
106560693  [KO:K07201]
106560757  calml4; calmodulin like 4 [KO:K02183]
106561019  [KO:K07189]
106561428  [KO:K07827]
106561704  prkar2b; protein kinase cAMP-dependent type II regulatory subunit beta [KO:K04739]
106561989  [KO:K03841] [EC:3.1.3.11]
106561993  phkb; phosphorylase kinase regulatory subunit beta [KO:K07190]
106562302  [KO:K07189]
106562335  [KO:K13296] [EC:3.1.4.17]
106562770  [KO:K02183]
106562868  [KO:K06277]
106562970  prkaa1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106563018  [KO:K02649]
106563168  [KO:K04438]
106563493  BAD; bcl2-associated agonist of cell death-like [KO:K02158]
106563500  CALM; calmodulin [KO:K02183]
106563639  [KO:K03259]
106563660  [KO:K00688] [EC:2.4.1.1]
106563715  [KO:K07189]
106563716  [KO:K07187]
106563760  [KO:K04440] [EC:2.7.11.24]
106563996  [KO:K04694]
106564139  [KO:K07196]
106564260  [KO:K04345] [EC:2.7.11.11]
106564303  [KO:K07207]
106564671  [KO:K04364]
106564733  [KO:K00844] [EC:2.7.1.1]
106564790  [KO:K03099]
106564869  [KO:K04456] [EC:2.7.11.1]
106564921  [KO:K07204]
106565134  [KO:K04739]
106565185  [KO:K07199]
106565196  [KO:K07189]
106565454  [KO:K07206]
106565531  [KO:K07200]
106566003  calml6; calmodulin like 6 [KO:K02183]
106566267  [KO:K07189]
106566433  [KO:K00693] [EC:2.4.1.11]
106566436  [KO:K04438]
106566498  [KO:K04375]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566777  [KO:K04739]
106567201  [KO:K05696] [EC:3.1.3.48]
106567289  [KO:K04695]
106567356  prkcz; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
106567474  INS; insulin [KO:K04526]
106567578  [KO:K04438]
106567661  [KO:K07193]
106567671  [KO:K04707] [EC:2.3.2.27]
106567700  [KO:K02649]
106567885  [KO:K16172]
106567964  [KO:K04688] [EC:2.7.11.1]
106567991  [KO:K07192]
106568009  [KO:K00844] [EC:2.7.1.1]
106568086  acaca; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106568163  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
106568356  [KO:K03841] [EC:3.1.3.11]
106568489  shc3; SHC adaptor protein 3 [KO:K17448]
106568502  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106568674  [KO:K07198] [EC:2.7.11.31]
106568747  [KO:K00922] [EC:2.7.1.153]
106568949  [KO:K02649]
106569146  KAPCB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106569190  [KO:K07200]
106569403  [KO:K02649]
106569535  [KO:K04369] [EC:2.7.12.2]
106569598  [KO:K06069] [EC:2.7.11.13]
106569653  [KO:K05695] [EC:3.1.3.48]
106569689  [KO:K07199]
106569824  [KO:K05695] [EC:3.1.3.48]
106569835  [KO:K04372] [EC:2.7.11.1]
106569917  [KO:K06277]
106569969  [KO:K07192]
106570130  [KO:K07188] [EC:3.1.1.79]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106571474  [KO:K04456] [EC:2.7.11.1]
106571634  [KO:K06269] [EC:3.1.3.16]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106572046  pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106572067  [KO:K07189]
106572271  [KO:K04739]
106572379  [KO:K07189]
106572479  [KO:K05696] [EC:3.1.3.48]
106572815  [KO:K18952] [EC:2.7.11.13]
106573038  [KO:K04739]
106573361  [KO:K02833]
106573900  [KO:K02649]
106574026  [KO:K04372] [EC:2.7.11.1]
106574304  [KO:K03083] [EC:2.7.11.26]
106574322  [KO:K07200]
106574897  [KO:K07190]
106575098  [KO:K07200]
106575127  irs2; insulin receptor substrate 2 [KO:K07187]
106575154  [KO:K03083] [EC:2.7.11.26]
106575570  [KO:K06279]
106576050  [KO:K07189]
106576083  [KO:K04739]
106576177  SOCS2a; suppressor of cytokine signaling 2-like [KO:K04695]
106576768  rhoq; ras homolog family member Q [KO:K07194]
106576776  [KO:K01106] [EC:3.1.3.56]
106576818  [KO:K06086]
106576863  [KO:K04440] [EC:2.7.11.24]
106577132  [KO:K07189]
106577251  IF4E; eukaryotic translation initiation factor 4E-like [KO:K03259]
106577399  [KO:K07188] [EC:3.1.1.79]
106577533  PYGM; glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
106577544  [KO:K06269] [EC:3.1.3.16]
106577610  [KO:K07202]
106577633  [KO:K16172]
106578056  [KO:K07190]
106578087  [KO:K02158]
106578264  [KO:K06276] [EC:2.7.11.1]
106578980  [KO:K07189]
106579004  [KO:K04440] [EC:2.7.11.24]
106579337  [KO:K01084] [EC:3.1.3.9]
106579597  [KO:K07200]
106579659  [KO:K07208]
106579953  ppp1cc; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
106580110  acacb; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106580123  rapgef1; Rap guanine nucleotide exchange factor 1 [KO:K06277]
106580340  4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
106580426  ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106580495  [KO:K00844] [EC:2.7.1.1]
106580530  [KO:K08845] [EC:2.7.11.1]
106580581  gk; glucokinase-like [KO:K12407] [EC:2.7.1.2]
106580783  [KO:K04438]
106581056  [KO:K00871] [EC:2.7.11.19]
106581130  [KO:K04688] [EC:2.7.11.1]
106581211  [KO:K07192]
106581334  [KO:K04456] [EC:2.7.11.1]
106581340  [KO:K15909] [EC:3.1.3.86]
106581359  [KO:K00922] [EC:2.7.1.153]
106581513  sh2b2; SH2B adaptor protein 2 [KO:K07193]
106581554  [KO:K07201]
106582120  gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
106582130  [KO:K07187]
106582637  [KO:K04456] [EC:2.7.11.1]
106583224  rhebl1; Ras homolog enriched in brain like 1 [KO:K07208]
106583465  [KO:K04739]
106583827  [KO:K07189]
106583950  [KO:K04527] [EC:2.7.10.1]
106584012  [KO:K02649]
106584181  [KO:K05695] [EC:3.1.3.48]
106584208  prkaa2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
106584368  [KO:K04372] [EC:2.7.11.1]
106584416  [KO:K17447]
106584546  [KO:K07189]
106584773  [KO:K03099]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106585103  [KO:K00844] [EC:2.7.1.1]
106585138  [KO:K08845] [EC:2.7.11.1]
106585167  [KO:K12407] [EC:2.7.1.2]
106585258  4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
106585609  [KO:K01106] [EC:3.1.3.56]
106585645  [KO:K06277]
106585658  [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106585772  [KO:K04456] [EC:2.7.11.1]
106586204  g6pc2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
106586650  [KO:K03083] [EC:2.7.11.26]
106586664  [KO:K07187]
106587014  tsc1; tuberous sclerosis 1 [KO:K07206]
106587034  [KO:K02649]
106587111  [KO:K04364]
106587291  [KO:K07190]
106587454  [KO:K07189]
106587516  [KO:K00844] [EC:2.7.1.1]
106587530  pde3b; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
106588110  [KO:K07204]
106589305  [KO:K01084] [EC:3.1.3.9]
106589306  [KO:K01084] [EC:3.1.3.9]
106589346  [KO:K04440] [EC:2.7.11.24]
106589379  [KO:K07189]
106589604  prkar1a; protein kinase cAMP-dependent type I regulatory subunit alpha [KO:K04739]
106589612  [KO:K00665] [EC:2.3.1.85]
106589637  g6pc3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
106589689  [KO:K04456] [EC:2.7.11.1]
106589825  [KO:K00844] [EC:2.7.1.1]
106589833  [KO:K04696]
106590260  pck2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
106590380  [KO:K07208]
106590432  [KO:K07200]
106591927  SOCS1; suppressor of cytokine signaling 1-like [KO:K04694]
106592041  [KO:K07200]
106592057  [KO:K04371] [EC:2.7.11.24]
106592286  [KO:K04345] [EC:2.7.11.11]
106592571  [KO:K07208]
106593005  [KO:K06279]
106593443  [KO:K03841] [EC:3.1.3.11]
106595429  [KO:K07196]
106596088  [KO:K04694]
106596806  [KO:K07208]
106597678  [KO:K02183]
106597685  [KO:K02183]
106598808  [KO:K00922] [EC:2.7.1.153]
106599005  [KO:K02649]
106599250  [KO:K07200]
106599427  [KO:K04694]
106599570  [KO:K04694]
106599750  KAPCB; cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
106600405  [KO:K02649]
106600441  [KO:K04369] [EC:2.7.12.2]
106600503  [KO:K06069] [EC:2.7.11.13]
106600510  [KO:K04527] [EC:2.7.10.1]
106600564  [KO:K07199]
106600575  eif4e2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
106600714  [KO:K04371] [EC:2.7.11.24]
106601272  CALM; calmodulin [KO:K02183]
106601280  [KO:K07196]
106601296  [KO:K01084] [EC:3.1.3.9]
106601579  [KO:K06269] [EC:3.1.3.16]
106601599  sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106601908  [KO:K07827]
106601915  [KO:K04696]
106601949  [KO:K00693] [EC:2.4.1.11]
106601986  [KO:K00693] [EC:2.4.1.11]
106602694  [KO:K04688] [EC:2.7.11.1]
106602804  RS6; 40S ribosomal protein S6 [KO:K02991]
106602828  cblb; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
106602890  [KO:K07201]
106602915  [KO:K04456] [EC:2.7.11.1]
106602930  socs4; suppressor of cytokine signaling 4 [KO:K04697]
106603056  [KO:K00688] [EC:2.4.1.1]
106603152  BAD; bcl2-associated agonist of cell death-like [KO:K02158]
106603160  [KO:K02183]
106603271  [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
106603416  [KO:K04707] [EC:2.3.2.27]
106603418  [KO:K07193]
106603521  [KO:K04688] [EC:2.7.11.1]
106603593  [KO:K16172]
106603721  [KO:K04438]
106603941  INS; insulin-like [KO:K04526]
106604288  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106604514  IF4EA; eukaryotic translation initiation factor 4E-1A [KO:K03259]
106604599  [KO:K06086]
106604736  [KO:K15909] [EC:3.1.3.86]
106604910  [KO:K04440] [EC:2.7.11.24]
106605012  [KO:K01106] [EC:3.1.3.56]
106605143  CALM; calmodulin [KO:K02183]
106605398  FLOT1; flotillin-1-like [KO:K07192]
106605704  [KO:K07188] [EC:3.1.1.79]
106606198  [KO:K04739]
106606205  [KO:K04739]
106606379  [KO:K07827]
106606415  gys1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
106606429  [KO:K04696]
106606461  [KO:K04739]
106606621  [KO:K07197]
106606839  [KO:K04345] [EC:2.7.11.11]
106606888  [KO:K06269] [EC:3.1.3.16]
106607067  [KO:K04364]
106607196  [KO:K01084] [EC:3.1.3.9]
106607205  [KO:K07196]
106607353  [KO:K06276] [EC:2.7.11.1]
106607890  [KO:K04456] [EC:2.7.11.1]
106607927  [KO:K07189]
106608223  CALM; calmodulin [KO:K02183]
106608398  [KO:K03259]
106608595  PYGM; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
106608616  [KO:K07202]
106608778  [KO:K16172]
106609064  [KO:K07187]
106609209  [KO:K04739]
106609244  [KO:K07189]
106609294  SOCS2b; suppressor of cytokine signaling 2-like [KO:K04695]
106609967  [KO:K04688] [EC:2.7.11.1]
106609995  RS6; 40S ribosomal protein S6-like [KO:K02991]
106610271  [KO:K00665] [EC:2.3.1.85]
106610329  [KO:K04739]
106610858  [KO:K04456] [EC:2.7.11.1]
106611171  calm1; calmodulin 1 [KO:K02183]
106611443  [KO:K03099]
106611459  PYGM; glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
106611739  [KO:K15909] [EC:3.1.3.86]
106612054  [KO:K04526]
106612378  CALM; calmodulin [KO:K02183]
106612385  [KO:K04696]
106612416  irs1; insulin receptor substrate 1 [KO:K16172]
106612430  [KO:K00844] [EC:2.7.1.1]
106612435  [KO:K00844] [EC:2.7.1.1]
106612473  cbl; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
106612814  [KO:K07192]
106612828  [KO:K00871] [EC:2.7.11.19]
106613000  [KO:K04688] [EC:2.7.11.1]
106613111  [KO:K04456] [EC:2.7.11.1]
106613172  [KO:K00922] [EC:2.7.1.153]
106613312  [KO:K07193]
106613442  prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106613635  [KO:K02649]
106613775  [KO:K04369] [EC:2.7.12.2]
106613792  [KO:K17447]
106613848  [KO:K04372] [EC:2.7.11.1]
106613931  pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
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  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
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Inoki K, Corradetti MN, Guan KL.
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Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
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Ruggero D, Sonenberg N.
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The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
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Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
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Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
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Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
sasa00010  Glycolysis / Gluconeogenesis
sasa00061  Fatty acid biosynthesis
sasa00500  Starch and sucrose metabolism
sasa04010  MAPK signaling pathway
sasa04070  Phosphatidylinositol signaling system
sasa04210  Apoptosis
KO pathway
ko04910   

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