KEGG   PATHWAY: sdu00230
Entry
sdu00230                    Pathway                                
Name
Purine metabolism - Seriola dumerili (greater amberjack)
Class
Metabolism; Nucleotide metabolism
Pathway map
sdu00230  Purine metabolism
sdu00230

Module
sdu_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:sdu00230]
sdu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:sdu00230]
sdu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:sdu00230]
sdu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:sdu00230]
sdu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:sdu00230]
sdu_M00546  Purine degradation, xanthine => urea [PATH:sdu00230]
sdu_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:sdu00230]
sdu_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:sdu00230]
Other DBs
GO: 0006163 0042278
Organism
Seriola dumerili (greater amberjack) [GN:sdu]
Gene
111216326  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
111216476  [KO:K01081] [EC:3.1.3.5]
111216521  [KO:K13293] [EC:3.1.4.53]
111216733  ak4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
111217043  pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
111217291  [KO:K08046] [EC:4.6.1.1]
111217306  pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
111217502  [KO:K13293] [EC:3.1.4.53]
111217971  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111218374  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111218419  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
111218788  [KO:K13761] [EC:3.1.4.35]
111218984  ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
111219014  [KO:K08046] [EC:4.6.1.1]
111219457  [KO:K03783] [EC:2.4.2.1]
111219537  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
111219587  [KO:K22600] [EC:4.6.1.2]
111219668  [KO:K12320] [EC:4.6.1.2]
111219713  [KO:K00940] [EC:2.7.4.6]
111219837  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
111220166  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
111220207  [KO:K00856] [EC:2.7.1.20]
111220264  nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
111220423  pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
111220689  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
111220743  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
111220806  dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
111220885  ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
111220950  urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
111221023  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
111221111  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
111221837  [KO:K07127] [EC:3.5.2.17]
111221872  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
111222066  [KO:K01490] [EC:3.5.4.6]
111222357  [KO:K01939] [EC:6.3.4.4]
111222450  [KO:K01769] [EC:4.6.1.2]
111222741  enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
111222984  gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
111223303  npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
111223319  [KO:K01514] [EC:3.6.1.11]
111223351  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
111223624  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
111223626  pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
111223696  [KO:K18437] [EC:3.1.4.53]
111223775  [KO:K13760]
111223983  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
111224043  pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
111224062  [KO:K19021] [EC:3.1.4.17]
111224115  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
111224193  pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
111224199  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
111224497  [KO:K13760]
111224517  [KO:K00088] [EC:1.1.1.205]
111224752  [KO:K13760]
111224766  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
111224899  [KO:K19572] [EC:3.5.4.4]
111225201  [KO:K19572] [EC:3.5.4.4]
111225227  [KO:K03783] [EC:2.4.2.1]
111225369  [KO:K01081] [EC:3.1.3.5]
111225572  [KO:K01081] [EC:3.1.3.5]
111225748  ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
111225877  [KO:K19970] [EC:3.1.3.5]
111225881  adssl1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
111225967  entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
111226364  ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
111226365  paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
111226436  [KO:K01769] [EC:4.6.1.2]
111226615  [KO:K00948] [EC:2.7.6.1]
111226653  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
111226863  [KO:K00940] [EC:2.7.4.6]
111227004  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111227038  cant1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
111227192  [KO:K13759]
111227562  [KO:K08041] [EC:4.6.1.1]
111227750  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
111227842  [KO:K08043] [EC:4.6.1.1]
111227880  [KO:K12305] [EC:3.6.1.6]
111227902  [KO:K08042] [EC:4.6.1.1]
111228038  [KO:K12319] [EC:4.6.1.2]
111228054  [KO:K13761] [EC:3.1.4.35]
111228089  pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
111228216  [KO:K00904] [EC:2.7.1.113]
111228470  [KO:K00760] [EC:2.4.2.8]
111228586  [KO:K00088] [EC:1.1.1.205]
111228756  [KO:K13293] [EC:3.1.4.53]
111228999  [KO:K13293] [EC:3.1.4.53]
111229009  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
111229116  [KO:K01835] [EC:5.4.2.2]
111229246  [KO:K08049] [EC:4.6.1.1]
111229434  [KO:K12304] [EC:3.6.1.6]
111229450  nt5c2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
111229540  [KO:K01509] [EC:3.6.1.-]
111229761  [KO:K19021] [EC:3.1.4.17]
111229881  [KO:K01490] [EC:3.5.4.6]
111230191  [KO:K00940] [EC:2.7.4.6]
111230194  nme3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
111230238  nudt9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
111230329  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
111230334  [KO:K00365] [EC:1.7.3.3]
111230421  lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
111230548  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
111230651  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
111230682  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
111230740  impdh2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
111230747  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
111230942  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
111230976  guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
111231027  [KO:K08041] [EC:4.6.1.1]
111231066  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
111231212  [KO:K13755] [EC:3.1.4.17]
111231267  [KO:K03783] [EC:2.4.2.1]
111231388  [KO:K13762] [EC:3.1.4.35]
111231422  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
111231447  gucy1a3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
111231448  gucy1b3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
111231536  [KO:K13760]
111231541  [KO:K13760]
111231659  allc; probable allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
111231971  pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
111232004  [KO:K01466] [EC:3.5.2.5]
111232397  [KO:K12319] [EC:4.6.1.2]
111232707  pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K08718] [EC:3.1.4.35]
111233148  [KO:K12324] [EC:4.6.1.2]
111233172  [KO:K08042] [EC:4.6.1.1]
111233203  [KO:K01081] [EC:3.1.3.5]
111233425  [KO:K12322] [EC:4.6.1.2]
111233435  [KO:K12324] [EC:4.6.1.2]
111233471  [KO:K12322] [EC:4.6.1.2]
111233908  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
111234078  [KO:K12323] [EC:4.6.1.2]
111234105  [KO:K01514] [EC:3.6.1.11]
111234111  [KO:K03783] [EC:2.4.2.1]
111234151  [KO:K00856] [EC:2.7.1.20]
111234169  [KO:K01081] [EC:3.1.3.5]
111234173  [KO:K13756] [EC:3.1.4.35]
111234317  [KO:K10807] [EC:1.17.4.1]
111234372  [KO:K12321] [EC:4.6.1.2]
111234774  [KO:K13761] [EC:3.1.4.35]
111234971  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
111235232  adss; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
111235244  [KO:K13757] [EC:3.1.4.35]
111235358  [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111235538  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111235549  [KO:K08048] [EC:4.6.1.1]
111235647  pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
111235684  gmpr2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
111235943  [KO:K01081] [EC:3.1.3.5]
111236021  [KO:K07127] [EC:3.5.2.17]
111236135  ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
111236210  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
111236552  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
111236556  ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
111236629  [KO:K08043] [EC:4.6.1.1]
111236639  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
111236692  gart; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
111236701  [KO:K08048] [EC:4.6.1.1]
111236711  prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
111236713  ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
111236830  [KO:K12321] [EC:4.6.1.2]
111237955  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
111237960  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
111238155  [KO:K10807] [EC:1.17.4.1]
111238436  [KO:K10808] [EC:1.17.4.1]
111238441  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
111238446  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
111238470  [KO:K01509] [EC:3.6.1.-]
111238510  ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
111238571  [KO:K01511] [EC:3.6.1.6]
111238586  [KO:K08042] [EC:4.6.1.1]
111238644  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
111238802  [KO:K13298] [EC:3.1.4.17 3.1.4.35]
111238872  pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
111238945  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
111239107  gmps; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
111239181  [KO:K12320] [EC:4.6.1.2]
111239206  [KO:K01081] [EC:3.1.3.5]
111239210  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
111239297  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
111239302  [KO:K13755] [EC:3.1.4.17]
111239543  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
111239565  [KO:K00942] [EC:2.7.4.8]
111239578  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
111240130  [KO:K19970] [EC:3.1.3.5]
111240303  [KO:K03783] [EC:2.4.2.1]
111240319  fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
111240334  [KO:K00939] [EC:2.7.4.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
sdu00030  Pentose phosphate pathway
sdu00220  Arginine biosynthesis
sdu00250  Alanine, aspartate and glutamate metabolism
sdu00260  Glycine, serine and threonine metabolism
sdu00340  Histidine metabolism
sdu00630  Glyoxylate and dicarboxylate metabolism
sdu00730  Thiamine metabolism
sdu00740  Riboflavin metabolism
sdu00790  Folate biosynthesis
KO pathway
ko00230   

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