KEGG   PATHWAY: shr04514
Entry
shr04514                    Pathway                                
Name
Cell adhesion molecule (CAM) interaction - Sarcophilus harrisii (Tasmanian devil)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
shr04514  Cell adhesion molecule (CAM) interaction
shr04514

Other DBs
GO: 0050839
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100913535  SAHAI-01; class I histocompatibility antigen, Gogo-OKO alpha chain-like precursor [KO:K06751]
100913539  ITGA8; integrin alpha-8 [KO:K06584]
100913933  ALCAM; CD166 antigen isoform X3 [KO:K06547]
100913968  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100914548  CLDN25; putative claudin-25 [KO:K06087]
100914556  [KO:K06087]
100914572  NFASC; neurofascin isoform X1 [KO:K06757]
100914634  NECTIN1; nectin-1 isoform X1 [KO:K06081]
100914774  NTNG2; netrin-G2 isoform X2 [KO:K16359]
100914830  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X7 [KO:K06478] [EC:3.1.3.48]
100916035  VCAM1; vascular cell adhesion protein 1 isoform X2 [KO:K06527]
100916101  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
100916278  JAM2; junctional adhesion molecule B [KO:K06735]
100916427  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
100916600  SDC4; syndecan-4 [KO:K16338]
100916626  IGSF11; immunoglobulin superfamily member 11 isoform X1 [KO:K06791]
100916690  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
100917327  [KO:K06087]
100917435  CNTNAP1; contactin-associated protein 1 [KO:K07379]
100917500  [KO:K06531]
100917543  CLDN2; claudin-2 [KO:K06087]
100917588  CLDN16; claudin-16 isoform X1 [KO:K06087]
100917763  CLDN10; claudin-10 isoform X1 [KO:K06087]
100917778  CLDN20; claudin-20 [KO:K06087]
100917864  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
100917908  NRXN1; neurexin-1 isoform X1 [KO:K07377]
100918070  CD40LG; CD40 ligand [KO:K03161]
100918482  NTNG1; netrin-G1 isoform X1 [KO:K07522]
100918485  [KO:K06752]
100918744  [KO:K06752]
100918796  NECTIN2; nectin-2 [KO:K06531]
100919045  CD226; CD226 antigen [KO:K06567]
100919092  CLDN23; claudin-23 [KO:K06087]
100919635  NRXN3; neurexin 3 isoform X1 [KO:K07377]
100919863  SAHAI-12; HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751]
100919995  CDH3; cadherin-3 [KO:K06796]
100920258  CDH1; cadherin-1 [KO:K05689]
100920489  ITGB7; integrin beta-7 [KO:K06590]
100920550  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
100920747  CLDN12; claudin-12 [KO:K06087]
100920802  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
100920822  SELP; P-selectin [KO:K06496]
100920907  F11R; junctional adhesion molecule A [KO:K06089]
100920966  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
100921023  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
100921084  SELL; L-selectin [KO:K06495]
100921234  PDCD1LG2; programmed cell death 1 ligand 2 isoform X2 [KO:K06708]
100921336  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
100921346  SELE; E-selectin isoform X1 [KO:K06494]
100921400  OCLN; occludin [KO:K06088]
100921429  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
100921525  CADM3; cell adhesion molecule 3 [KO:K06780]
100921679  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100921722  NEO1; neogenin isoform X1 [KO:K06766]
100921943  SDC3; syndecan-3 [KO:K16337]
100922464  SLITRK5; SLIT and NTRK-like protein 5 isoform X1 [KO:K25836]
100922474  [KO:K06752]
100922986  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
100923003  [KO:K06752]
100923185  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
100923805  [KO:K06087]
100923854  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100924434  SLITRK4; SLIT and NTRK-like protein 4 isoform X1 [KO:K25835]
100924457  PTPRS; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
100924560  MAG; myelin-associated glycoprotein [KO:K06771]
100924632  ITGA9; integrin alpha-9 [KO:K06585]
100924825  CD22; B-cell receptor CD22 [KO:K06467]
100924877  CDH5; cadherin-5 [KO:K06533]
100924917  CLDN11; claudin-11 [KO:K06087]
100924958  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
100925533  [KO:K06752]
100925715  ITGB2; integrin beta-2 [KO:K06464]
100925729  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
100925801  [KO:K06752]
100925862  JAML; junctional adhesion molecule-like [KO:K28137]
100925944  [KO:K06088]
100926092  CDH4; cadherin-4 [KO:K06797]
100926163  [KO:K06087]
100926320  [KO:K06751]
100926378  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
100926565  CXADR; coxsackievirus and adenovirus receptor [KO:K06788]
100926734  CLDN18; claudin-18 [KO:K06087]
100927089  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
100927395  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
100927438  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
100927706  CNTN1; contactin-1 isoform X1 [KO:K06759]
100927947  [KO:K06751]
100928708  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
100928807  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
100928906  [KO:K06751]
100929053  ITGAV; integrin alpha-V [KO:K06487]
100929219  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100929293  CLDN6; claudin-6 [KO:K06087]
100929342  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
100929412  CLDN7; claudin-7 [KO:K06087]
100929545  SDC2; syndecan-2 [KO:K16336]
100929550  CLDN9; claudin-9 [KO:K06087]
100929759  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
100929908  [KO:K06710]
100930057  CDH2; cadherin-2 [KO:K06736]
100930424  NECTIN3; nectin-3 [KO:K06592]
100930880  CNTN2; contactin-2 [KO:K06760]
100930980  [KO:K06752]
100931105  [KO:K06751]
100931572  CD99; CD99 antigen isoform X1 [KO:K06520]
100931645  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
100931651  CLDN14; claudin-14 [KO:K06087]
100931754  NEGR1; neuronal growth regulator 1 [KO:K06775]
100931776  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100931842  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
100931877  CD6; T-cell differentiation antigen CD6 [KO:K06456]
100932092  ESAM; endothelial cell-selective adhesion molecule isoform X1 [KO:K06787]
100932176  CLDN17; claudin-17 [KO:K06087]
100932180  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
100932375  CD2; T-cell surface antigen CD2 isoform X2 [KO:K06449]
100932849  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
100933398  CLDN19; claudin-19 [KO:K06087]
100933468  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
100933653  CLDN1; claudin-1 [KO:K06087]
100933667  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
100933777  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
100933786  GLG1; Golgi apparatus protein 1 [KO:K06816]
100933797  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
100934598  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
100935096  CDH15; LOW QUALITY PROTEIN: cadherin-15 [KO:K06809]
100935139  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
100935349  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
105749122  [KO:K06751]
105749124  [KO:K06751]
105749194  [KO:K06751]
105749195  [KO:K06751]
105749196  [KO:K06751]
105749197  [KO:K06751]
105749242  SIGLEC1; LOW QUALITY PROTEIN: sialoadhesin [KO:K06548]
105749503  SPN; leukosialin [KO:K06477]
105749825  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
105749987  CLDN34; claudin-34 [KO:K06087]
105749991  XG; glycoprotein Xg isoform X1 [KO:K06520]
105750039  ICOS; inducible T-cell costimulator [KO:K06713]
105750068  PDCD1; programmed cell death protein 1 [KO:K06744]
105750327  CD276; CD276 antigen isoform X1 [KO:K06746]
105750522  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
105750614  [KO:K06751]
105750643  CLDN15; claudin-15 [KO:K06087]
105751090  NLGN3; neuroligin-3 [KO:K07378]
116420868  CLDN5; claudin-5 [KO:K06087]
116422336  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
116423477  CLDN4; claudin-4 [KO:K06087]
116423479  CLDN3; claudin-3 [KO:K06087]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
shr04520  Adherens junction
shr04530  Tight junction
shr04610  Complement and coagulation cascades
shr04660  T cell receptor signaling pathway
shr04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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