KEGG   PATHWAY: ssc04530
Entry
ssc04530                    Pathway                                
Name
Tight junction - Sus scrofa (pig)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ssc04530  Tight junction
ssc04530

Other DBs
GO: 0005923
Organism
Sus scrofa (pig) [GN:ssc]
Gene
100038007  PCD1B; CD1B antigen precursor [KO:K06448]
100038008  CD1E; T-cell surface glycoprotein CD1e, membrane-associated precursor [KO:K06448]
100124526  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
100127131  [KO:K07374]
100127138  F11R; junctional adhesion molecule A precursor [KO:K06089]
100127486  CLDN7; claudin-7 precursor [KO:K06087]
100135051  TUBA1A; tubulin alpha-1A chain [KO:K07374]
100144492  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100145887  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
100145903  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100151951  TUBA4A; tubulin alpha-4A chain [KO:K07374]
100151957  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
100152635  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
100152815  EZR; ezrin [KO:K08007]
100153106  BVES; blood vessel epicardial substance [KO:K21108]
100153161  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
100153175  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100153199  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
100153752  CLDN10; claudin-10 precursor [KO:K06087]
100153817  CLDN20; claudin-20 precursor [KO:K06087]
100153972  RAB8B; ras-related protein Rab-8B [KO:K07902]
100153988  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
100154462  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100154503  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
100154518  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100154707  RAB13; ras-related protein Rab-13 [KO:K06109]
100155138  [KO:K07374]
100155875  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
100156235  CLDN23; claudin-23 [KO:K06087]
100156537  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100157729  DLG1; disks large homolog 1 isoform X14 [KO:K12076]
100157760  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100157793  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
100157963  CGN; cingulin [KO:K06102]
100158003  [KO:K07374]
100158213  AMOT; angiomotin isoform X1 [KO:K16819]
100174945  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
100174962  ACTR2; actin-related protein 2 [KO:K17260]
100174963  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100174964  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100174965  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100233201  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
100294674  CLDN12; claudin-12 [KO:K06087]
100294676  CLDN18; claudin-18 precursor [KO:K06087]
100294681  CLDN17; claudin-17 [KO:K06087]
100294682  CLDN19; claudin-19 [KO:K06087]
100294683  CLDN22; claudin-22 [KO:K06087]
100302016  CLDN11; claudin-11 [KO:K06087]
100302017  CLDN14; claudin-14 [KO:K06087]
100302018  CLDN15; claudin-15 [KO:K06087]
100302019  CLDN16; claudin-16 [KO:K06087]
100302020  CLDN6; claudin-6 [KO:K06087]
100302021  CLDN8; claudin-8 [KO:K06087]
100302022  CLDN9; claudin-9 [KO:K06087]
100510930  [KO:K07374]
100510946  EPB41L4B; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
100511004  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X5 [KO:K21066]
100511006  RAB8A; ras-related protein Rab-8A [KO:K07901]
100511102  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
100511453  MARVELD3; MARVEL domain-containing protein 3 isoform 1 [KO:K21099]
100511975  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
100512009  PARD3; LOW QUALITY PROTEIN: partitioning defective 3 homolog [KO:K04237]
100512083  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
100512213  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
100512609  SYMPK; symplekin isoform X1 [KO:K06100]
100512633  RUNX1; runt-related transcription factor 1 [KO:K08367]
100513065  TJP2; tight junction protein ZO-2 [KO:K06098]
100513412  ACTN1; alpha-actinin-1 [KO:K05699]
100513610  AMOTL1; angiomotin-like protein 1 isoform X2 [KO:K06104]
100514504  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
100514741  AFDN; afadin isoform X1 [KO:K05702]
100515868  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X9 [KO:K07200]
100516124  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
100516384  DLG2; disks large homolog 2 isoform X8 [KO:K12075]
100516404  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
100516641  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
100517006  IGSF5; immunoglobulin superfamily member 5 isoform X2 [KO:K06786]
100517284  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100517409  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
100517699  CRB3; protein crumbs homolog 3 [KO:K06090]
100518125  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
100518253  TUBA8; tubulin alpha-8 chain [KO:K07374]
100519437  CLDN25; putative claudin-25 [KO:K06087]
100520043  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
100520244  MYL6B; myosin light chain 6B [KO:K12751]
100520418  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X5 [KO:K04431] [EC:2.7.12.2]
100520699  NF2; merlin isoform X1 [KO:K16684]
100520932  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23 [KO:K05631]
100521255  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
100521615  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
100521736  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
100521992  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
100522059  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
100523596  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
100523696  AMOTL2; LOW QUALITY PROTEIN: angiomotin-like protein 2 [KO:K06104]
100524203  PATJ; inaD-like protein isoform X1 [KO:K06092]
100524587  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100524748  MYH14; myosin-14 isoform X1 [KO:K10352]
100524853  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100524932  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100533200  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100621121  [KO:K06087]
100621470  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
100622769  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
100623355  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
100623575  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100623628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100625166  CLDN1; claudin-1 [KO:K06087]
100626455  TJP3; tight junction protein ZO-3 isoform X3 [KO:K06097]
100626771  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
100627149  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100627924  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
100736682  TJP1; tight junction protein ZO-1 isoform X10 [KO:K05701]
100736996  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
100737053  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100737993  CTTN; src substrate cortactin isoform X1 [KO:K06106]
100738589  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102159531  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
102166598  JAM2; junctional adhesion molecule B [KO:K06735]
110255967  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
110256128  LLGL1; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 1 [KO:K06094]
110258629  [KO:K06087]
110259543  SYNPO; LOW QUALITY PROTEIN: synaptopodin [KO:K21112]
110260417  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
110261011  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
396566  [KO:K06087]
396609  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
396610  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
396617  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
396690  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
396738  ACTR3; actin-related protein 3 [KO:K18584]
396785  CD1.1; T-cell surface glycoprotein CD1a precursor [KO:K06448]
396807  MYL6; myosin light polypeptide 6 [KO:K12751]
396849  RHOA; transforming protein RhoA [KO:K04513]
396903  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
396904  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
396913  JUN; transcription factor AP-1 [KO:K04448]
396997  CLDN5; claudin-5 [KO:K06087]
397019  ITGB1; integrin beta-1 precursor [KO:K05719]
397088  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
397089  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
397090  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
397136  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
397149  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
397236  OCLN; occludin [KO:K06088]
397445  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
397447  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
397470  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
397504  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
397555  GATA4; transcription factor GATA-4 [KO:K09183]
397652  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
397653  ACTG1; actin, cytoplasmic 2 [KO:K05692]
397656  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
403154  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
414396  ACTB; actin, cytoplasmic 1 [KO:K05692]
414399  MRLC2; myosin regulatory light chain 12B [KO:K12757]
414426  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
445527  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
494457  RDX; radixin [KO:K05762]
494458  MSN; moesin [KO:K05763]
692192  PCNA; proliferating cell nuclear antigen [KO:K04802]
733578  CLDN4; claudin-4 [KO:K06087]
733594  TUBA1B; tubulin alpha-1B chain [KO:K07374]
733637  [KO:K12757]
733684  CLDN2; claudin-2 [KO:K06087]
780428  CDC42; cell division control protein 42 homolog [KO:K04393]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ssc04520  Adherens junction
ssc04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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