KEGG   PATHWAY: tsr04530
Entry
tsr04530                    Pathway                                
Name
Tight junction - Thamnophis sirtalis (common garter snake)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tsr04530  Tight junction
tsr04530

Other DBs
GO: 0005923
Organism
Thamnophis sirtalis (common garter snake) [GN:tsr]
Gene
106551028  claudin-34-like isoform X1 [KO:K06087]
106542319  claudin-17-like [KO:K06087]
106542322  claudin-8-like [KO:K06087]
106548150  claudin-22-like [KO:K06087]
106555213  claudin-9-like [KO:K06087]
106556674  claudin-5-like [KO:K06087]
106553735  claudin-4-like [KO:K06087]
106553736  claudin-4-like isoform X1 [KO:K06087]
106553739  claudin-3-like [KO:K06087]
106553765  CLDN2; claudin-2 [KO:K06087]
106540346  claudin-4-like [KO:K06087]
106541378  CLDN11; claudin-11 isoform X1 [KO:K06087]
106549469  CLDN14; claudin-14 isoform X1 [KO:K06087]
106550346  CLDN20; claudin-20 [KO:K06087]
106554256  CLDN19; claudin-19 [KO:K06087]
106537859  claudin-15-like [KO:K06087]
106552815  CLDN18; claudin-18 isoform X1 [KO:K06087]
106537734  claudin-22-like [KO:K06087]
106539809  CLDN23; claudin-23 [KO:K06087]
106537427  CLDN12; claudin-12 [KO:K06087]
106539594  occludin-like [KO:K06088]
106554770  occludin-like [KO:K06088]
106547421  F11R; junctional adhesion molecule A [KO:K06089]
106541694  JAM2; junctional adhesion molecule B [KO:K06735]
106553788  BVES; blood vessel epicardial substance [KO:K21108]
106554373  cell division control protein 42 homolog [KO:K04393]
106543835  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
106553924  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
106556574  partitioning defective 6 homolog alpha-like [KO:K06093]
106544072  MPP5; MAGUK p55 subfamily member 5 [KO:K06091]
106540811  MPDZ; multiple PDZ domain protein [KO:K06095]
106550150  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
106547252  protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
106541376  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
106552948  AMOT; angiomotin [KO:K16819]
106554660  AMOTL1; angiomotin-like protein 1 [KO:K06104]
106539249  AMOTL2; angiomotin-like protein 2 [KO:K06104]
106551029  ARHGAP17; rho GTPase-activating protein 17 [KO:K20638]
106551143  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K04392]
106538277  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
106550302  NF2; merlin [KO:K16684]
106549459  LLGL2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
106551581  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
106555805  protein scribble homolog [KO:K16175]
106539819  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
106539522  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
106546744  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
106544475  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform [KO:K04354]
106542078  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
106555957  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
106543000  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
106544000  PARD3; partitioning defective 3 homolog [KO:K04237]
106546455  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
106549310  TJP1; tight junction protein ZO-1 [KO:K05701]
106541599  TJAP1; tight junction-associated protein 1 [KO:K06105]
106555662  disks large homolog 2-like [KO:K12075]
106538774  disks large homolog 2-like [KO:K12075]
106547184  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
106553260  E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
106541064  CGN; cingulin [KO:K06102]
106542887  CGNL1; cingulin-like protein 1 [KO:K21110]
106546033  ARHGEF2; rho guanine nucleotide exchange factor 2 [KO:K12791]
106552511  transforming protein RhoA-like isoform X1 [KO:K04513]
106539135  RHOA; transforming protein RhoA [KO:K04513]
106546574  GATA4; transcription factor GATA-4 [KO:K09183]
106554160  MARVEL domain-containing protein 3-like [KO:K21099]
106540861  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
106547350  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
106550161  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106539258  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106545185  JUN; transcription factor AP-1 [KO:K04448]
106538296  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
106540822  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
106546608  SYMPK; symplekin [KO:K06100]
106556638  PCNA; proliferating cell nuclear antigen [KO:K04802]
106546690  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
106538863  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
106549617  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
106543606  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
106553140  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
106542060  EZR; ezrin [KO:K08007]
106543863  RDX; radixin isoform X1 [KO:K05762]
106554163  MSN; moesin [KO:K05763]
106547762  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
106548496  actin, cytoplasmic 2 [KO:K05692]
106555246  voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
106544410  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
106554087  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
106547907  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106551377  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106546189  CTTN; src substrate cortactin [KO:K06106]
106538883  src substrate protein p85-like [KO:K06106]
106547073  ACTR2; actin-related protein 2 [KO:K17260]
106556969  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
106556793  ACTR3; actin-related protein 3 [KO:K18584]
106547585  actin-related protein 2/3 complex subunit 1A [KO:K05757]
106549202  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
106547108  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
106543107  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
106552924  actin-related protein 2/3 complex subunit 5 [KO:K05754]
106554780  WASP homolog-associated protein with actin, membranes and microtubules-like [KO:K20479]
106546034  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
106546148  VASP; vasodilator-stimulated phosphoprotein [KO:K06274]
106555867  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
106544707  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106544797  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
106549734  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
106549506  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
106548632  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
106543111  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
106540101  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
106554405  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
106547369  uncharacterized protein LOC106547369 [KO:K07200]
106556964  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
106548582  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
106540707  MYH10; myosin-10 isoform X1 [KO:K10352]
106551878  MYH11; myosin-11 [KO:K10352]
106552055  MYH9; myosin-9 [KO:K10352]
106553386  myosin-10-like isoform X1 [KO:K10352]
106548183  myosin light polypeptide 6-like [KO:K12751]
106538627  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
106544631  myosin regulatory light polypeptide 9 [KO:K12757]
106549760  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
106555736  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like [KO:K05631]
106554892  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1-like [KO:K05631]
106542936  SYNPO; synaptopodin [KO:K21112]
106555707  alpha-actinin-4 [KO:K05699]
106539595  ACTN1; alpha-actinin-1 [KO:K05699]
106552731  MICALL2; MICAL-like protein 2 [KO:K21068]
106554669  RAB8A; ras-related protein Rab-8A [KO:K07901]
106542875  RAB8B; ras-related protein Rab-8B [KO:K07902]
106550518  ras-related protein Rap-1A-like [KO:K04353]
106544187  ITGB1; integrin beta-1 [KO:K05719]
106542759  afadin-like [KO:K05702]
106537964  tight junction protein ZO-2-like isoform X1 [KO:K06098]
106550917  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
106553911  ras-related protein Rap-2c [KO:K07839]
106546517  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
106545766  tubulin alpha-1A chain [KO:K07374]
106556095  tubulin alpha-3 chain [KO:K07374]
106545017  tubulin alpha-8 chain-like [KO:K07374]
106540316  tubulin alpha-4A chain [KO:K07374]
106543324  tubulin alpha-8 chain [KO:K07374]
106546597  tubulin alpha-1B chain-like [KO:K07374]
106546598  tubulin alpha chain-like [KO:K07374]
106546601  tubulin alpha-1C chain [KO:K07374]
106550675  tubulin alpha-3 chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
tsr04520  Adherens junction
tsr04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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