KEGG   PATHWAY: tsr04810
Entry
tsr04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Thamnophis sirtalis (common garter snake)
Class
Cellular Processes; Cell motility
Pathway map
tsr04810  Regulation of actin cytoskeleton
tsr04810

Other DBs
GO: 0030036
Organism
Thamnophis sirtalis (common garter snake) [GN:tsr]
Gene
106544059  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
106555676  lysophosphatidic acid receptor 1-B-like [KO:K04289]
106539958  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
106549815  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
106553862  lysophosphatidic acid receptor 6-like [KO:K04275]
106548359  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
106554744  CXCL12; stromal cell-derived factor 1 [KO:K10031]
106539054  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
106554431  prothrombin-like [KO:K01313] [EC:3.4.21.5]
106538988  proteinase-activated receptor 1-like [KO:K03914]
106539008  proteinase-activated receptor 1-like [KO:K03914]
106547000  INS; insulin [KO:K04526]
106554022  pro-epidermal growth factor-like [KO:K04357]
106555130  pro-epidermal growth factor-like [KO:K04357]
106542651  FGF2; fibroblast growth factor 2 [KO:K18497]
106552933  FGF7; fibroblast growth factor 7 [KO:K04358]
106549061  FGF8; fibroblast growth factor 8 [KO:K04358]
106549292  FGF3; fibroblast growth factor 3 [KO:K04358]
106549294  FGF4; fibroblast growth factor 4 [KO:K04358]
106543519  FGF10; fibroblast growth factor 10 [KO:K04358]
106549816  FGF18; fibroblast growth factor 18 [KO:K04358]
106544293  FGF9; fibroblast growth factor 9 [KO:K04358]
106538537  FGF20; fibroblast growth factor 20 [KO:K04358]
106545598  fibroblast growth factor 22-like [KO:K04358]
106551644  FGF16; fibroblast growth factor 16 [KO:K04358]
106546689  FGF19; fibroblast growth factor 19 [KO:K22603]
106538689  FGF21; fibroblast growth factor 21 [KO:K22429]
106544589  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
106541330  platelet-derived growth factor C [KO:K05450]
106551812  PDGFD; platelet-derived growth factor D [KO:K05450]
106540321  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
106539158  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106545617  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
106554429  fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
106555648  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
106540885  fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
106547766  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106544514  FN1; fibronectin [KO:K05717]
106544267  ITGA1; integrin alpha-1 [KO:K06480]
106557240  ITGA2B; integrin alpha-IIb [KO:K06476]
106557334  ITGA3; integrin alpha-3 [KO:K06482]
106555446  ITGA4; integrin alpha-4 [KO:K06483]
106542467  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
106555426  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
106537905  ITGA8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
106552584  ITGA9; integrin alpha-9 [KO:K06585]
106556503  integrin alpha-11-like [KO:K06587]
106552079  ITGAV; integrin alpha-V [KO:K06487]
106549614  ITGAL; integrin alpha-L [KO:K05718]
106544187  ITGB1; integrin beta-1 [KO:K05719]
106553055  ITGB2; integrin beta-2 [KO:K06464]
106548113  ITGB3; integrin beta-3 [KO:K06493]
106537435  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
106546931  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
106551612  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
106557227  ITGB8; integrin beta-8 [KO:K06591]
106540453  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
106542367  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
106541595  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
106545970  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
106544433  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
106546796  complement component C6-like [KO:K03995]
106540086  complement component C6-like [KO:K03995]
106540087  complement component C6-like [KO:K03995]
106547902  complement component C7-like [KO:K03996]
106540414  C8A; complement component C8 alpha chain [KO:K03997]
106556020  complement component C8 beta chain-like [KO:K03998]
106540407  C8B; complement component C8 beta chain [KO:K03998]
106541987  complement component C8 gamma chain-like [KO:K03999]
106546497  C9; complement component C9 [KO:K04000]
106543761  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
106553054  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
106548938  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106541460  FYVE, RhoGEF and PH domain-containing protein 3-like [KO:K05722]
106539030  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
106546560  crk-like protein [KO:K04438]
106543399  CRK; adapter molecule crk [KO:K04438]
106554137  CRKL; crk-like protein [KO:K04438]
106544801  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
106551377  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106545945  SOS2; son of sevenless homolog 2 [KO:K03099]
106544570  HRAS; GTPase HRas [KO:K02833]
106556456  GTPase KRas [KO:K07827]
106538715  GTPase KRas-like isoform X1 [KO:K07827]
106556469  GTPase NRas [KO:K07828]
106548361  RRAS; ras-related protein R-Ras [KO:K07830]
106549375  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
106539618  MRAS; ras-related protein M-Ras [KO:K07831]
106545691  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106541175  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106543200  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106552169  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106538977  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
106549720  guanine nucleotide exchange factor VAV2 [KO:K05730]
106556080  guanine nucleotide exchange factor VAV3-like [KO:K05730]
106546455  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
106553001  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
106550529  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
106542299  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
106541257  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106552768  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
106549118  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106555305  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106554657  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106539801  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106541379  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106541029  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106541072  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106549882  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
106542680  rho guanine nucleotide exchange factor 1-like [KO:K12330]
106545978  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
106557251  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
106552511  transforming protein RhoA-like isoform X1 [KO:K04513]
106539135  RHOA; transforming protein RhoA [KO:K04513]
106551143  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K04392]
106538277  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
106551146  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
106554373  cell division control protein 42 homolog [KO:K04393]
106554254  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106554861  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
106553250  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
106542667  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
106544754  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
106544185  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
106549734  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
106549506  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
106543664  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
106547126  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106548633  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106538243  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
106547769  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
106548413  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
106548632  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
106549692  MYL5; myosin light chain 5 [KO:K12753]
106538627  myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
106544631  myosin regulatory light polypeptide 9 [KO:K12757]
106548962  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
106540707  MYH10; myosin-10 isoform X1 [KO:K10352]
106551878  MYH11; myosin-11 [KO:K10352]
106552055  MYH9; myosin-9 [KO:K10352]
106553386  myosin-10-like isoform X1 [KO:K10352]
106552520  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
106545675  protein diaphanous homolog 2-like [KO:K05741]
106544692  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
106537995  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
106548377  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
106553414  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
106548252  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
106542496  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
106549913  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
106551456  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
106549718  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
106543665  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
106538402  brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
106553010  ENAH; protein enabled homolog isoform X1 [KO:K05746]
106554386  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
106554053  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
106554726  cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
106555600  cytoplasmic FMR1-interacting protein 1-like [KO:K05749]
106543520  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
106541487  NCKAP1L; nck-associated protein 1-like [KO:K05750]
106549667  NCKAP1; nck-associated protein 1 [KO:K05750]
106552403  ABI2; abl interactor 2 [KO:K05751]
106548369  abl interactor 2-like [KO:K05751]
106541736  BRK1; protein BRICK1 [KO:K05752]
106545875  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
106547073  ACTR2; actin-related protein 2 [KO:K17260]
106556969  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
106556793  ACTR3; actin-related protein 3 [KO:K18584]
106547585  actin-related protein 2/3 complex subunit 1A [KO:K05757]
106549202  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
106547108  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
106543107  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
106552924  actin-related protein 2/3 complex subunit 5 [KO:K05754]
106548496  actin, cytoplasmic 2 [KO:K05692]
106543186  PFN3; profilin-3 [KO:K05759]
106543424  PFN2; profilin-2 isoform X1 [KO:K05759]
106556444  PFN1; profilin-1 [KO:K05759]
106550766  PFN4; profilin-4 [KO:K05759]
106552320  uncharacterized protein LOC106552320 [KO:K05760]
106551399  paxillin-like [KO:K05760]
106542060  EZR; ezrin [KO:K08007]
106543863  RDX; radixin isoform X1 [KO:K05762]
106554163  MSN; moesin [KO:K05763]
106557433  TMSB4X; thymosin beta-4 [KO:K05764]
106553180  cofilin-2-like [KO:K05765]
106554205  CFL2; cofilin-2 isoform X1 [KO:K05765]
106547119  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106553628  protein phosphatase Slingshot homolog 1-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106538800  protein phosphatase Slingshot homolog 2-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
106546133  ras GTPase-activating-like protein IQGAP1 [KO:K16848]
106539009  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
106557195  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
106542729  SCIN; adseverin [KO:K05768]
106552044  gelsolin-like [KO:K05768]
106555707  alpha-actinin-4 [KO:K05699]
106539595  ACTN1; alpha-actinin-1 [KO:K05699]
106540739  APC; adenomatous polyposis coli protein [KO:K02085]
106554481  adenomatous polyposis coli protein 2-like [KO:K02085]
106548849  uncharacterized protein LOC106548849 [KO:K05769]
106537866  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
tsr04010  MAPK signaling pathway
tsr04510  Focal adhesion
tsr04520  Adherens junction
KO pathway
ko04810   
LinkDB

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