KEGG   PATHWAY: tup04115
Entry
tup04115                    Pathway                                
Name
p53 signaling pathway - Tupaia chinensis (Chinese tree shrew)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
tup04115  p53 signaling pathway
tup04115

Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102467759  CCNG2; cyclin G2 [KO:K10146]
102468317  CCNE1; cyclin E1 [KO:K06626]
102468800  SFN; stratifin [KO:K06644]
102468854  [KO:K08738]
102469326  PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D [KO:K10147] [EC:3.1.3.16]
102469788  RPRM; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
102470940  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102471776  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102472330  SERPINB5; serpin family B member 5 [KO:K10139]
102472614  DDB2; damage specific DNA binding protein 2 [KO:K10140]
102472926  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102473924  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102474260  STEAP3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
102474520  GORAB; golgin, RAB6 interacting [KO:K19748]
102474592  BCL2; BCL2, apoptosis regulator [KO:K02161]
102476523  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102476587  FAS; Fas cell surface death receptor [KO:K04390]
102476798  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102477021  IGFBP3; insulin like growth factor binding protein 3 [KO:K10138]
102477647  PERP; PERP, TP53 apoptosis effector [KO:K10136]
102477797  BID; BH3 interacting domain death agonist [KO:K04726]
102478438  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
102478468  SERPINE1; serpin family E member 1 [KO:K03982]
102478505  RCHY1; ring finger and CHY zinc finger domain containing 1 [KO:K10144] [EC:2.3.2.27]
102479545  [KO:K08738]
102479902  CCND2; cyclin D2 [KO:K10151]
102480466  SESN1; sestrin 1 [KO:K10141]
102480757  CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
102481989  CCNB1; cyclin B1 [KO:K05868]
102482195  ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
102482563  CCNG1; cyclin G1 [KO:K10145]
102482790  PIDD1; p53-induced death domain protein 1 [KO:K10130]
102482911  ZMAT3; zinc finger matrin-type 3 [KO:K10137]
102484276  TSC2; tuberous sclerosis 2 [KO:K07207]
102484524  [KO:K10145]
102484613  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
102484993  CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
102485324  PFN4; profilin family member 4 [KO:K10133] [EC:1.-.-.-]
102486626  BCL2L1; BCL2 like 1 [KO:K04570]
102487119  [KO:K02187] [EC:3.4.22.56]
102487473  CD82; CD82 molecule [KO:K06509]
102487856  SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
102488001  SHISA5; shisa family member 5 [KO:K10135]
102488432  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102489114  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102489149  [KO:K04722]
102489331  CDK1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102490159  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102490248  IGF1; insulin like growth factor 1 [KO:K05459]
102490651  CCND1; cyclin D1 [KO:K04503]
102491015  AIFM2; apoptosis inducing factor, mitochondria associated 2 [KO:K22745]
102492088  CCNE2; cyclin E2 [KO:K06626]
102492360  SIVA1; SIVA1 apoptosis inducing factor [KO:K22744]
102492501  RFWD2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
102492504  TP73; tumor protein p73 [KO:K10148]
102492983  [KO:K08738]
102493291  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
102493707  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
102494456  SESN3; sestrin 3 [KO:K10141]
102494691  PPP1R13L; protein phosphatase 1 regulatory subunit 13 like [KO:K27356]
102494972  MDM4; MDM4, p53 regulator [KO:K10127]
102496069  RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
102496191  [KO:K08738]
102496861  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102496953  GTSE1; G2 and S-phase expressed 1 [KO:K10129]
102497162  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
102497170  [KO:K04722]
102497602  THBS1; thrombospondin 1 [KO:K16857]
102498355  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102498809  EI24; EI24, autophagy associated transmembrane protein [KO:K10134]
102498982  [KO:K05868]
102499577  CCND3; cyclin D3 [KO:K10152]
102499950  BBC3; BCL2 binding component 3 [KO:K10132]
102500015  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
102501319  CCNB2; cyclin B2 [KO:K21770]
102502093  ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
102502813  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102503112  ZNF385A; zinc finger protein 385A [KO:K26543]
102503238  TP53; tumor protein p53 [KO:K04451]
102503296  [KO:K08738]
102503343  [KO:K08738]
106733204  [KO:K08738]
106734104  [KO:K08738]
106734874  [KO:K08738]
106735223  [KO:K08738]
106735631  [KO:K08738]
106735729  [KO:K08738]
106735920  [KO:K08738]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
tup04110  Cell cycle
tup04210  Apoptosis
tup04218  Cellular senescence
KO pathway
ko04115   

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