KEGG   PATHWAY: xla04115
Entry
xla04115                    Pathway                                
Name
p53 signaling pathway - Xenopus laevis (African clawed frog)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
xla04115  p53 signaling pathway
xla04115

Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
398148  atm.L; ATM serine/threonine kinase L homeolog [KO:K04728] [EC:2.7.11.1]
398179  chek2.L; checkpoint kinase 2 L homeolog [KO:K06641] [EC:2.7.11.1]
398197  atr.L; serine/threonine-protein kinase atr [KO:K06640] [EC:2.7.11.1]
398191  chek1.S; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
108696394  chek1.L; serine/threonine-protein kinase Chk1-like isoform X1 [KO:K02216] [EC:2.7.11.1]
108706001  RAB6-interacting golgin-like isoform X1 [KO:K19748]
108714491  gorab.L; RAB6-interacting golgin isoform X1 [KO:K19748]
108713153  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
108711092  mdm2.L; E3 ubiquitin-protein ligase Mdm2-like isoform X1 [KO:K06643] [EC:2.3.2.27]
398466  mdm4.S; protein Mdm4 [KO:K10127]
397926  tp53.L; cellular tumor antigen p53 [KO:K04451]
108703451  tp53.S; cellular tumor antigen p53-like [KO:K04451]
108700197  ppp1r13l.S; relA-associated inhibitor isoform X2 [KO:K27356]
447427  ppp1r13l.L; protein phosphatase 1 regulatory subunit 13 like L homeolog [KO:K27356]
492305  cdkn1a.L; cyclin-dependent kinase inhibitor 1 [KO:K06625]
108709405  cdkn1a.S; cyclin-dependent kinase inhibitor 1 [KO:K06625]
379161  ccnd1.S; G1/S-specific cyclin-D1 b [KO:K04503]
379937  ccnd1.L; G1/S-specific cyclin-D1 [KO:K04503]
447748  ccndx.L; G1/S-specific cyclin-D1 [KO:K04503]
447541  MGC83948 protein [KO:K04503]
734882  ccnd2.S; cyclin D2 S homeolog [KO:K10151]
373667  ccnd2.L; G1/S-specific cyclin-D2 [KO:K10151]
379406  cdk4.S; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
496334  cdk6.L; cyclin-dependent kinase 6 L homeolog [KO:K02089] [EC:2.7.11.22]
108718479  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
108719900  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
380219  ccne2.L; cyclin E2 L homeolog [KO:K06626]
397840  ccne1.L; G1/S-specific cyclin-E1 [KO:K06626]
495419  ccne2.S; uncharacterized protein LOC495419 [KO:K06626]
397841  ccne1.S; G1/S-specific cyclin-E3 [KO:K06626]
432036  cdk2.L; uncharacterized protein LOC432036 [KO:K02206] [EC:2.7.11.22]
399314  cdk2.S; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
108702018  protein reprimo [KO:K10128]
108702402  rprm.S; protein reprimo [KO:K10128]
397742  ccnb1.2.S; G2/mitotic-specific cyclin-B1 [KO:K05868]
379888  ccnb1.2.L; cyclin B1 L homeolog [KO:K05868]
398163  ccnb1.S; cyclin B1 S homeolog [KO:K05868]
108718066  ccnb1.L; G2/mitotic-specific cyclin-B1-like [KO:K05868]
397743  ccnb2.S; G2/mitotic-specific cyclin-B2 [KO:K21770]
398888  ccnb2.L; uncharacterized protein LOC398888 [KO:K21770]
398162  cyclin B5 [KO:K21770]
380246  cdk1.S; cyclin-dependent kinase 1-A [KO:K02087] [EC:2.7.11.22 2.7.11.23]
379785  cdk1.L; cyclin-dependent kinase 1-B [KO:K02087] [EC:2.7.11.22 2.7.11.23]
379224  gadd45a.S; growth arrest and DNA damage inducible alpha S homeolog [KO:K04402]
399196  gadd45g.L; growth arrest and DNA damage inducible gamma L homeolog [KO:K04402]
379285  gadd45g.S; uncharacterized protein LOC379285 [KO:K04402]
101027271  gadd45b.S; growth arrest and DNA damage inducible beta S homeolog [KO:K04402]
108714209  gadd45a.L; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
108712402  gadd45b.L; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
447452  gtse1.S; G2 and S-phase expressed 1 S homeolog [KO:K10129]
734417  gtse1.L; G2 and S-phase expressed 1 L homeolog [KO:K10129]
108709889  znf385a.S; zinc finger protein 385A isoform X1 [KO:K26543]
108708631  znf385a.L; zinc finger protein 385A isoform X1 [KO:K26543]
108697171  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
108696050  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
108713866  pidd1.L; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
404688  tnfrsf10b.L; tumor necrosis factor receptor superfamily member 10b L homeolog precursor [KO:K04722]
373559  casp8.L; caspase 8 L homeolog [KO:K04398] [EC:3.4.22.61]
724076  bid.S; BH3 interacting domain death agonist S homeolog [KO:K04726]
108704383  bid.L; BH3-interacting domain death agonist isoform X1 [KO:K04726]
373637  bax.S; BCL2-associated X protein L homeolog [KO:K02159]
108696744  bax.L; apoptosis regulator BAX-like [KO:K02159]
100049128  siva1.S; uncharacterized protein LOC100049128 [KO:K22744]
100037065  siva1.L; SIVA1, apoptosis-inducing factor L homeolog [KO:K22744]
398251  bcl2l1.S; apoptosis regulator R11 [KO:K04570]
108700971  apoptosis regulator R11-like [KO:K04570]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
444383  tp53i3.S; tumor protein p53 inducible protein 3 S homeolog [KO:K10133] [EC:1.-.-.-]
495297  ei24.S; etoposide induced 2.4 S homeolog [KO:K10134]
108696395  ei24.L; etoposide-induced protein 2.4 homolog [KO:K10134]
444660  perp.S; PERP, TP53 apoptosis effector S homeolog [KO:K10136]
734854  zmat3.L; zinc finger matrin-type 3 L homeolog [KO:K10137]
108718092  zmat3.S; zinc finger matrin-type protein 3 [KO:K10137]
443864  siah1.L; siah E3 ubiquitin protein ligase 1 L homeolog [KO:K04506] [EC:2.3.2.27]
108715479  siah1.S; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
444530  cycs.S; cytochrome c, testis-specific [KO:K08738]
443888  cyct.S; cytochrome c, somatic A [KO:K08738]
414705  cyct.L; cytochrome c, somatic B [KO:K08738]
108718882  cycs.L; cytochrome c, testis-specific [KO:K08738]
444261  apaf1.L; apoptotic peptidase activating factor 1 L homeolog [KO:K02084]
373560  casp9.S; caspase 9 S homeolog [KO:K04399] [EC:3.4.22.62]
397720  casp3.2.S; caspase-3 [KO:K02187] [EC:3.4.22.56]
100036910  casp3.2.L; uncharacterized protein LOC100036910 [KO:K02187] [EC:3.4.22.56]
108696268  aifm2.L; ferroptosis suppressor protein 1 [KO:K22745]
100049086  aifm2.S; ferroptosis suppressor protein 1 [KO:K22745]
108712492  insulin-like growth factor I-A [KO:K05459]
108711020  igf1.S; insulin-like growth factor I-A [KO:K05459]
779433  serpine1.L; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 L homeolog precursor [KO:K03982]
100049768  serpine1.S; plasminogen activator inhibitor 1 [KO:K03982]
108695463  adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
108718612  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
444244  cd82.S; CD82 molecule S homeolog [KO:K06509]
432226  cd82.L; uncharacterized protein LOC432226 [KO:K06509]
379508  thbs1.L; thrombospondin 1 L homeolog precursor [KO:K16857]
779026  thbs1.S; thrombospondin-1 [KO:K16857]
444699  serpinb5.S; serpin B5 [KO:K10139]
108718725  serpinb5.L; serpin B5 [KO:K10139]
108713786  ddb2.L; DNA damage-binding protein 2 [KO:K10140]
108715228  ddb2.S; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
443815  rrm2.1.L; ribonucleotide reductase M2, gene 1 L homeolog [KO:K10808] [EC:1.17.4.1]
380465  rrm2.2.L; ribonucleotide reductase M2 polypeptide [KO:K10808] [EC:1.17.4.1]
379056  rrm2b.S; ribonucleotide reductase M2 B (TP53 inducible) S homeolog [KO:K10808] [EC:1.17.4.1]
108695407  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
379559  sesn1.L; sestrin-1 [KO:K10141]
443904  sesn3.L; sestrin-3 [KO:K10141]
108717942  sesn1.S; sestrin-1-like [KO:K10141]
108710010  sesn3.S; sestrin-3 [KO:K10141]
414641  sesn2.L; sestrin 2 L homeolog [KO:K20394]
443672  sesn2.S; sestrin-2 [KO:K20394]
399142  pten.L; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100505440  pten.S; uncharacterized protein LOC100505440 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108703213  tsc2.S; tuberin isoform X1 [KO:K07207]
108701656  tsc2.L; tuberin isoform X3 [KO:K07207]
108701235  steap3.L; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
100158422  cop1.L; E3 ubiquitin-protein ligase COP1 isoform X2 [KO:K10143] [EC:2.3.2.27]
108715625  cop1.S; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
496013  rchy1.L; ring finger and CHY zinc finger domain containing 1 L homeolog [KO:K10144] [EC:2.3.2.27]
379404  ccng1.L; cyclin G1 L homeolog [KO:K10145]
779347  ccng1.S; cyclin G1 S homeolog [KO:K10145]
431934  ccng2.S; cyclin G2 S homeolog [KO:K10146]
444607  ccng2.L; cyclin G2 L homeolog [KO:K10146]
443988  ppm1d.L; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
380383  ppm1d.S; protein phosphatase, Mg2+/Mn2+ dependent 1D S homeolog [KO:K10147] [EC:3.1.3.16]
108696624  tp73.L; tumor protein p73 isoform X1 [KO:K10148]
108697705  tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
xla04110  Cell cycle
xla04210  Apoptosis
xla04218  Cellular senescence
KO pathway
ko04115   
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