Entry Name AMPK signaling pathway - Zalophus californianus (California sea lion)
Description AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Zalophus californianus (California sea lion) [GN:
zca ]
Gene 113908103 STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271 ]
113908519 PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584 ]
113909061 PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584 ]
113909515 PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583 ]
113911293 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048 ]
113911510 PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
113911563 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
113911688 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
113913271 PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199 ]
113913854 PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456 ]
113914217 PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
113914325 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
113917002 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
113917022 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
113917179 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
113918247 PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
113918397 PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354 ]
113918625 PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583 ]
113918898 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
113919399 STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532 ]
113919503 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
113920067 PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200 ]
113921449 ADIPOR2; LOW QUALITY PROTEIN: adiponectin receptor protein 2 [KO:K07297 ]
113921957 PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
113924526 PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354 ]
113924761 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
113924910 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205 ]
113925005 PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202 ]
113925887 PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354 ]
113926341 PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
113928897 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
113929021 PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354 ]
113929208 PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198 ] [EC:2.7.11.31 ]
113929378 PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
113930651 PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583 ]
113933479 PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
113933591 CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333 ]
113933699 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
113934022 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
113934482 PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199 ]
113935813 PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456 ]
113939022 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
113939029 SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197 ]
113939593 SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191 ]
Compound C00354 D-Fructose 1,6-bisphosphate
C00665 beta-D-Fructose 2,6-bisphosphate
C00668 alpha-D-Glucose 6-phosphate
C01172 beta-D-Glucose 6-phosphate
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C09731 Epigallocatechin gallate
Reference Authors Steinberg GR, Kemp BE
Title AMPK in Health and Disease.
Journal Reference Authors Hardie DG.
Title The AMP-activated protein kinase pathway--new players upstream and downstream.
Journal Reference Authors Russo GL, Russo M, Ungaro P
Title AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
Journal Reference Authors Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
Title AMPK in the brain: its roles in energy balance and neuroprotection.
Journal Reference Authors Li J, McCullough LD
Title Effects of AMP-activated protein kinase in cerebral ischemia.
Journal Reference Authors Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
Title The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
Journal Reference Authors Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
Title Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
Journal Reference Authors Shackelford DB, Shaw RJ
Title The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Journal Reference Authors Chung JH, Manganiello V, Dyck JR
Title Resveratrol as a calorie restriction mimetic: therapeutic implications.
Journal Reference Authors Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
Title Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
Journal Reference Authors Towler MC, Hardie DG
Title AMP-activated protein kinase in metabolic control and insulin signaling.
Journal Reference Authors Richter EA, Hargreaves M
Title Exercise, GLUT4, and skeletal muscle glucose uptake.
Journal Reference Authors Kahn BB, Alquier T, Carling D, Hardie DG
Title AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
Journal Reference Authors Minokoshi Y, Toda C, Okamoto S
Title Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
Journal Reference Authors Guggino WB, Stanton BA
Title New insights into cystic fibrosis: molecular switches that regulate CFTR.
Journal Reference Authors Cheng A, Saltiel AR
Title More TORC for the gluconeogenic engine.
Journal Reference Authors Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
Title TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
Journal Reference Authors Morris DL, Rui L
Title Recent advances in understanding leptin signaling and leptin resistance.
Journal Reference Authors Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
Title Role of hypothalamic AMP-kinase in food intake regulation.
Journal Reference Authors Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
Title Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
Journal Related zca01040 Biosynthesis of unsaturated fatty acids
zca04920 Adipocytokine signaling pathway
KO pathway
