KEGG   PATHWAY: zca04151
Entry
zca04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Zalophus californianus (California sea lion)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
zca04151  PI3K-Akt signaling pathway
zca04151

Other DBs
GO: 0043491
Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113907859  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
113907921  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
113907934  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
113908138  ITGA3; integrin alpha-3 [KO:K06482]
113908174  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
113908204  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
113908233  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
113908302  ITGA2B; integrin alpha-IIb [KO:K06476]
113908519  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
113908830  [KO:K04546]
113908849  THBS1; thrombospondin-1 [KO:K16857]
113908929  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
113908965  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
113908972  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113908976  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113908979  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113909061  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
113909092  [KO:K16197]
113909166  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113909358  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
113909359  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
113909364  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
113909515  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
113909591  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
113909595  ITGA11; integrin alpha-11 [KO:K06587]
113909774  [KO:K02991]
113909873  PGF; placenta growth factor isoform X1 [KO:K16859]
113910017  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113910054  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
113910084  [KO:K16197]
113910123  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
113910139  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
113910148  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
113910489  [KO:K03258]
113910568  [KO:K04537]
113910930  COL1A2; collagen alpha-2(I) chain [KO:K06236]
113911010  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113911106  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113911193  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
113911233  RHEB; GTP-binding protein Rheb [KO:K07208]
113911235  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113911293  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
113911302  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
113911303  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
113911311  [KO:K02991]
113911366  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
113911404  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
113911491  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
113911563  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
113911568  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
113911688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113911718  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
113911755  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
113911759  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
113911882  LAMB1; laminin subunit beta-1 [KO:K05636]
113911883  LAMB4; laminin subunit beta-4 [KO:K06245]
113911910  IL6; interleukin-6 [KO:K05405]
113912225  [KO:K05414]
113912320  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113912489  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
113912652  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
113912763  [KO:K07205]
113912855  OSM; oncostatin-M [KO:K05418]
113912875  YWHAH; 14-3-3 protein eta [KO:K16198]
113912921  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
113913157  LAMA1; laminin subunit alpha-1 [KO:K05637]
113913496  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
113913517  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
113913769  CHRM1; muscarinic acetylcholine receptor M1 isoform X1 [KO:K04129]
113913854  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
113914021  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
113914023  [KO:K02991]
113914083  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113914217  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
113914285  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
113914325  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
113914350  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
113914420  FGF3; fibroblast growth factor 3 [KO:K04358]
113914533  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
113914539  BAD; bcl2-associated agonist of cell death [KO:K02158]
113914579  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
113914580  INS; insulin [KO:K04526]
113914876  HRAS; GTPase HRas isoform X1 [KO:K02833]
113914948  RELA; transcription factor p65 [KO:K04735]
113915497  FGF4; fibroblast growth factor 4 [KO:K04358]
113915998  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
113916135  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
113916178  [KO:K06238]
113916244  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113916275  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
113916388  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
113916395  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
113916429  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
113916460  [KO:K02991]
113916503  [KO:K02991]
113916517  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113916548  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
113916549  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
113916632  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
113916638  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
113916679  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
113916693  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
113916807  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
113916936  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
113916979  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
113917002  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
113917006  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
113917022  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113917132  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
113917133  [KO:K04659]
113917179  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113917183  [KO:K02991]
113917416  [KO:K02991]
113917472  PSPN; persephin [KO:K25416]
113917572  [KO:K03259]
113917683  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
113917831  NRTN; neurturin [KO:K25414]
113917860  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
113917926  [KO:K02991]
113917982  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
113918089  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
113918374  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
113918397  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
113918509  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113918531  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
113918596  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
113918625  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
113918785  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113918898  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113919173  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
113919193  FGF9; fibroblast growth factor 9 [KO:K04358]
113919296  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
113919318  FN1; fibronectin isoform X1 [KO:K05717]
113919387  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
113919409  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
113919503  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
113919652  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
113919740  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
113919807  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
113919813  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
113919931  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
113919946  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
113919967  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
113919987  [KO:K04392]
113920032  IRS1; insulin receptor substrate 1 [KO:K16172]
113920081  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
113920140  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
113920155  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
113920330  [KO:K02991]
113920402  [KO:K16197]
113920510  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
113920550  [KO:K02991]
113920594  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
113920658  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
113920778  [KO:K04542]
113920779  [KO:K04079]
113921318  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
113921349  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
113921399  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
113921413  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
113921510  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
113921542  [KO:K04545]
113921674  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
113921771  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113921783  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113921792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113921844  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
113921869  ITGA5; integrin alpha-5 [KO:K06484]
113921916  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
113921944  KITLG; kit ligand isoform X1 [KO:K05461]
113922030  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
113922031  HSP90B1; endoplasmin [KO:K09487]
113922120  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
113922161  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
113922232  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
113922282  [KO:K03259]
113922348  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
113922508  FGF23; fibroblast growth factor 23 [KO:K22428]
113922563  NTF3; neurotrophin-3 [KO:K04356]
113922601  [KO:K02991]
113922626  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
113922712  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
113922743  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
113922860  VWF; von Willebrand factor isoform X1 [KO:K03900]
113922890  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
113922988  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
113923116  FGF6; fibroblast growth factor 6 [KO:K04358]
113923121  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
113923259  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
113923411  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
113923614  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
113923816  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
113923917  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
113924071  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
113924083  [KO:K06253]
113924180  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
113924224  [KO:K04545]
113924266  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
113924272  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
113924318  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
113924319  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
113924526  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
113924570  [KO:K02991]
113924665  [KO:K13302] [EC:2.7.11.1]
113924698  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
113924761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113924866  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
113924910  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
113925034  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
113925046  [KO:K04546]
113925050  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
113925082  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
113925121  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113925283  FGF17; fibroblast growth factor 17 [KO:K04358]
113925290  SPP1; osteopontin isoform X1 [KO:K06250]
113925340  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
113925471  TLR2; toll-like receptor 2 [KO:K10159]
113925505  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
113925688  AREG; amphiregulin [KO:K09782]
113925708  FGF20; fibroblast growth factor 20 [KO:K04358]
113925832  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113925887  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
113925933  IL2; interleukin-2 [KO:K05429]
113926298  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
113926300  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
113926341  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
113926366  FOXO3; forkhead box protein O3 [KO:K09408]
113926602  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
113926702  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
113926716  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
113926992  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
113927036  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
113927071  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
113927108  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
113927327  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
113927548  THBS2; thrombospondin-2 [KO:K04659]
113927654  [KO:K04079]
113927678  PRL; prolactin isoform X1 [KO:K05439]
113927959  VEGFA; vascular endothelial growth factor A [KO:K05448]
113927968  THEM4; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
113928431  ITGA2; integrin alpha-2 [KO:K06481]
113928514  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
113928606  [KO:K04736]
113928720  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
113928740  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
113928812  GHR; growth hormone receptor isoform X1 [KO:K05080]
113928868  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
113928886  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
113928897  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113929012  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
113929021  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
113929051  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
113929128  [KO:K16197]
113929136  PRLR; prolactin receptor [KO:K05081]
113929208  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
113929280  F2R; proteinase-activated receptor 1 [KO:K03914]
113929338  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
113929359  FGF18; fibroblast growth factor 18 [KO:K04358]
113929378  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
113929402  IL4; interleukin-4 [KO:K05430]
113929516  [KO:K03259]
113929550  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
113929577  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
113929600  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
113929766  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
113929889  FGF10; fibroblast growth factor 10 [KO:K04358]
113929897  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
113929939  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
113930564  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
113930597  [KO:K07210]
113930605  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
113930651  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
113930731  [KO:K04382] [EC:3.1.3.16]
113930742  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
113930805  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
113930823  MTCP1; protein p13 MTCP-1 [KO:K16837]
113930871  [KO:K04537]
113931090  FGF16; fibroblast growth factor 16 [KO:K04358]
113931141  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
113931206  VEGFD; vascular endothelial growth factor D [KO:K05449]
113931429  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
113931430  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
113931469  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
113931754  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113931774  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
113931879  NRAS; GTPase NRas [KO:K07828]
113931997  LAMC2; laminin subunit gamma-2 [KO:K06246]
113932035  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113932092  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
113932130  EFNA4; ephrin-A4 [KO:K05462]
113932244  TNN; tenascin-N [KO:K06252]
113932254  LAMB3; laminin subunit beta-3 [KO:K06244]
113932298  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
113932378  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113932448  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
113932485  YWHAG; 14-3-3 protein gamma [KO:K16198]
113932555  [KO:K02539]
113932706  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
113932722  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
113933137  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
113933140  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
113933192  TNR; tenascin-R isoform X1 [KO:K06252]
113933246  [KO:K02991]
113933249  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
113933251  EFNA1; ephrin-A1 [KO:K05462]
113933258  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
113933431  TSC2; tuberin isoform X1 [KO:K07207]
113933467  IL7; interleukin-7 isoform X1 [KO:K05431]
113933479  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
113933485  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
113933591  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
113933601  EPO; erythropoietin [KO:K05437]
113933613  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
113933699  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
113933707  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
113933743  [KO:K07205]
113933750  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
113934022  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
113934060  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
113934076  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
113934126  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
113934167  TNC; tenascin isoform X1 [KO:K06252]
113934213  TSC1; hamartin isoform X1 [KO:K07206]
113934282  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
113934419  IFNB1; interferon beta [KO:K05415]
113934429  PKN3; LOW QUALITY PROTEIN: serine/threonine-protein kinase N3 [KO:K23692]
113934433  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
113934655  [KO:K05414]
113934667  [KO:K05414]
113934678  [KO:K05414]
113934682  [KO:K05414]
113934741  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
113934760  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
113934983  RPS6; 40S ribosomal protein S6 [KO:K02991]
113934985  [KO:K05414]
113935000  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
113935130  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
113935281  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
113935294  [KO:K13304] [EC:2.7.11.1]
113935342  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
113935537  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113935588  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
113935675  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
113935813  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
113935926  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
113936078  NGF; beta-nerve growth factor [KO:K02582]
113936418  NTF4; neurotrophin-4 [KO:K12457]
113936527  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
113936668  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
113936714  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
113936764  FGF21; fibroblast growth factor 21 [KO:K22429]
113936987  BCL2L1; bcl-2-like protein 1 [KO:K04570]
113936996  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
113937087  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
113937127  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113937297  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
113937311  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
113937324  YWHAQ; 14-3-3 protein theta [KO:K16197]
113937362  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
113937768  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
113938191  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
113938319  [KO:K04079]
113938536  LAMA5; laminin subunit alpha-5 [KO:K06240]
113938552  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
113938556  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
113938559  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
113939007  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
113939022  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
113939072  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
113939402  VTN; vitronectin [KO:K06251]
113939460  CHAD; chondroadherin [KO:K06248]
113939476  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
113939477  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
113939501  YWHAE; 14-3-3 protein epsilon [KO:K06630]
113939539  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
113939549  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
113939579  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
113939587  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113939650  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
113939655  [KO:K05438]
113939702  ITGB3; integrin beta-3 [KO:K06493]
113939823  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118355992  [KO:K02991]
118356016  [KO:K02539]
118356046  [KO:K25414]
118356097  [KO:K02991]
118356150  [KO:K02991]
118356200  [KO:K02991]
118356242  [KO:K02991]
118356554  [KO:K07210]
118356752  [KO:K04545]
118357039  [KO:K06630]
118357090  [KO:K02991]
118357326  [KO:K02991]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
zca00010  Glycolysis / Gluconeogenesis
zca04010  MAPK signaling pathway
zca04012  ErbB signaling pathway
zca04062  Chemokine signaling pathway
zca04064  NF-kappa B signaling pathway
zca04068  FoxO signaling pathway
zca04110  Cell cycle
zca04115  p53 signaling pathway
zca04150  mTOR signaling pathway
zca04210  Apoptosis
zca04370  VEGF signaling pathway
zca04510  Focal adhesion
zca04620  Toll-like receptor signaling pathway
zca04630  JAK-STAT signaling pathway
zca04662  B cell receptor signaling pathway
zca04910  Insulin signaling pathway
KO pathway
ko04151   

DBGET integrated database retrieval system