KEGG   PATHWAY: bbub03013
Entry
bbub03013                   Pathway                                
Name
Nucleocytoplasmic transport - Bubalus bubalis (water buffalo)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
bbub03013  Nucleocytoplasmic transport
bbub03013

Other DBs
GO: 0050658
Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102389356  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
102389646  [KO:K03231]
102390062  [KO:K12160]
102390517  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X2 [KO:K12172] [EC:2.3.2.-]
102390541  THOC6; THO complex subunit 6 homolog isoform X1 [KO:K13175]
102390768  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
102390823  KPNA2; importin subunit alpha-1 [KO:K15043]
102390868  NUP62; nuclear pore glycoprotein P62 [KO:K14306]
102390983  NUP37; nucleoporin Nup37 [KO:K14302]
102391087  POM121L2; POM121-like protein 2 [KO:K14316]
102391267  XPO6; exportin-6 isoform X1 [KO:K25204]
102391555  NUP155; nuclear pore complex protein Nup155 [KO:K14312]
102392039  [KO:K14325]
102392134  UPF3B; regulator of nonsense transcripts 3B isoform X2 [KO:K14328]
102392477  [KO:K12160]
102392707  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
102393167  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
102393331  [KO:K03231]
102394282  TNPO2; transportin-2 isoform X1 [KO:K18727]
102394678  TPR; nucleoprotein TPR [KO:K09291]
102395018  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
102395074  [KO:K12160]
102395351  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
102395587  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
102395868  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
102396247  TNPO3; transportin-3 isoform X1 [KO:K15436]
102396980  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
102397051  NUP62CL; nucleoporin-62 C-terminal-like protein isoform X1 [KO:K14306]
102397113  AHCTF1; protein ELYS isoform X2 [KO:K25129]
102397521  NUP210; nuclear pore membrane glycoprotein 210 isoform X2 [KO:K14314]
102397525  [KO:K07936]
102397562  IPO4; importin-4 [KO:K20221]
102398088  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
102398179  CSE1L; exportin-2 [KO:K18423]
102398320  THOC5; THO complex subunit 5 homolog isoform X1 [KO:K13174]
102398445  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
102398736  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
102398770  XPO4; exportin-4 isoform X1 [KO:K25203]
102398818  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
102398864  IPO5; importin-5 [KO:K20222]
102398867  [KO:K12879]
102398939  NUP42; nucleoporin NUP42 isoform X1 [KO:K14321]
102399601  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
102400112  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
102400325  POM121C; nuclear envelope pore membrane protein POM 121C isoform X1 [KO:K14316]
102400599  [KO:K14284]
102400683  KPNA7; importin subunit alpha-8 isoform X2 [KO:K15043]
102400748  THOC1; THO complex subunit 1 [KO:K12878]
102400845  PYM1; partner of Y14 and mago isoform X2 [KO:K14294]
102400901  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
102400906  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
102400924  [KO:K14284]
102401008  THOC2; THO complex subunit 2 isoform X8 [KO:K12879]
102401096  IPO11; importin-11 isoform X1 [KO:K25201]
102401275  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
102401334  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X3 [KO:K14297]
102401924  KPNA6; importin subunit alpha-7 isoform X2 [KO:K15042]
102402331  NXT2; NTF2-related export protein 2 [KO:K14285]
102402428  [KO:K14284]
102402532  THOC3; THO complex subunit 3 [KO:K12880]
102403059  AAAS; aladin isoform X2 [KO:K14320]
102403177  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X7 [KO:K12875]
102403734  KPNA4; importin subunit alpha-3 [KO:K23583]
102403854  [KO:K12160]
102404152  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
102404906  [KO:K12877]
102404945  [KO:K14324]
102405070  SRRM1; serine/arginine repetitive matrix protein 1 isoform X8 [KO:K13171]
102405242  XPOT; exportin-T [KO:K14288]
102405388  KPNA1; importin subunit alpha-5 [KO:K23940]
102405407  NUP88; nuclear pore complex protein Nup88 isoform X2 [KO:K14318]
102405501  IPO9; importin-9 [KO:K20224]
102405651  NUP50; nuclear pore complex protein Nup50 isoform X2 [KO:K14295]
102405697  NUP153; nuclear pore complex protein Nup153 isoform X3 [KO:K14296]
102406182  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
102406775  KPNB1; importin subunit beta-1 [KO:K14293]
102407097  PNN; pinin isoform X1 [KO:K13114]
102407157  IPO13; importin-13 isoform X1 [KO:K25202]
102407159  GLE1; nucleoporin GLE1 [KO:K18723]
102407291  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
102407454  NXT1; NTF2-related export protein 1 [KO:K14285]
102407467  [KO:K12160]
102407534  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102407893  TNPO1; transportin-1 isoform X1 [KO:K18752]
102408020  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
102408122  XPO1; exportin-1 isoform X1 [KO:K14290]
102408131  [KO:K15043]
102408147  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
102408621  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
102408642  SEC13; protein SEC13 homolog isoform X2 [KO:K14004]
102408816  NUP35; nucleoporin NUP35 [KO:K14313]
102409018  CASC3; protein CASC3 [KO:K14323]
102409305  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
102409418  [KO:K14284]
102409600  [KO:K03231]
102409733  NUP160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
102409741  [KO:K14325]
102409785  THOC7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
102410142  RANBP17; ran-binding protein 17 isoform X1 [KO:K24115]
102410226  XPO5; exportin-5 [KO:K14289]
102411052  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
102411067  NUP43; nucleoporin Nup43 isoform X1 [KO:K14305]
102411287  SNUPN; snurportin-1 isoform X1 [KO:K13151]
102412383  [KO:K15043]
102412462  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X2 [KO:K14325]
102412833  ALYREF; THO complex subunit 4 [KO:K12881]
102412958  MAGOH; protein mago nashi homolog isoform X2 [KO:K12877]
102413264  [KO:K18655] [EC:5.6.2.7]
102413433  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
102413601  DDX19A; ATP-dependent RNA helicase DDX19A isoform X1 [KO:K18655] [EC:5.6.2.7]
102413618  [KO:K12877]
102413745  KPNA5; importin subunit alpha-6 [KO:K15042]
102413788  NUP54; nucleoporin P54 [KO:K14308]
102414267  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
102414369  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
102414629  XPO7; exportin-7 isoform X1 [KO:K18460]
102414846  IPO8; importin-8 isoform X3 [KO:K18755]
102415087  IPO7; importin-7 [KO:K20223]
102415180  [KO:K14284]
102415657  RAN; GTP-binding nuclear protein Ran [KO:K07936]
102416651  [KO:K12877]
112577766  [KO:K14284]
112581190  [KO:K03231]
112582034  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
112587408  [KO:K03231]
112587779  [KO:K07936]
123327506  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
123327673  [KO:K12160]
123464891  RAE1; mRNA export factor [KO:K14298]
123464944  [KO:K03231]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
bbub03015  mRNA surveillance pathway
KO pathway
ko03013   

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