KEGG   PATHWAY: caua04110
Entry
caua04110                   Pathway                                
Name
Cell cycle - Carassius auratus (goldfish)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
caua04110  Cell cycle
caua04110

Other DBs
GO: 0000278
Organism
Carassius auratus (goldfish) [GN:caua]
Gene
113038219  cdc23; cell division cycle protein 23 homolog [KO:K03355]
113038244  [KO:K04382] [EC:3.1.3.16]
113038245  [KO:K03094]
113038584  [KO:K12456]
113038593  [KO:K06618]
113038614  [KO:K03364]
113038615  [KO:K02216] [EC:2.7.11.1]
113038625  [KO:K03875]
113038645  [KO:K13375]
113038646  [KO:K13375]
113038826  [KO:K04402]
113038827  [KO:K04402]
113038936  [KO:K04402]
113039356  [KO:K10152]
113039357  [KO:K10152]
113039361  [KO:K06625]
113039368  [KO:K06625]
113039403  [KO:K02540] [EC:5.6.2.3]
113039673  [KO:K06670]
113039867  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
113039956  [KO:K04498] [EC:2.3.1.48]
113040126  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113040376  [KO:K02540] [EC:5.6.2.3]
113040866  [KO:K17454]
113041221  [KO:K03357]
113041391  [KO:K17454]
113041620  [KO:K17454]
113041650  [KO:K10151]
113042267  [KO:K03347]
113042350  [KO:K04377]
113042401  [KO:K06671]
113042574  [KO:K11268] [EC:2.3.1.-]
113042576  [KO:K02212] [EC:5.6.2.3]
113042948  [KO:K06624]
113043021  [KO:K06624]
113043081  [KO:K10151]
113043101  [KO:K06636]
113043120  [KO:K10151]
113043334  [KO:K26117]
113043366  [KO:K03083] [EC:2.7.11.26]
113044064  [KO:K03083] [EC:2.7.11.26]
113044271  [KO:K11267]
113044442  [KO:K04685]
113044512  [KO:K06679]
113044527  [KO:K06631] [EC:2.7.11.21]
113044687  [KO:K04683]
113044747  [KO:K03083] [EC:2.7.11.26]
113045066  [KO:K11266]
113045114  [KO:K13376]
113045170  [KO:K11266]
113045351  [KO:K02542] [EC:5.6.2.3]
113045352  [KO:K03347]
113045475  [KO:K04402]
113045603  [KO:K10500]
113045625  [KO:K03363]
113045640  [KO:K04402]
113045652  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
113045698  [KO:K04377]
113045699  [KO:K04377]
113045713  [KO:K04682]
113045915  [KO:K06671]
113046027  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113046046  [KO:K03364]
113046685  [KO:K02209] [EC:5.6.2.3]
113046789  [KO:K03350]
113046818  [KO:K03868] [EC:2.3.2.32]
113046821  [KO:K04498] [EC:2.3.1.48]
113047153  [KO:K04498] [EC:2.3.1.48]
113047341  [KO:K02091] [EC:2.7.11.22]
113047604  [KO:K03868] [EC:2.3.2.32]
113047643  [KO:K10151]
113048132  [KO:K06624]
113048137  [KO:K03350]
113048209  orc5; origin recognition complex subunit 5 isoform X1 [KO:K02607]
113048224  [KO:K06643] [EC:2.3.2.27]
113048313  [KO:K04498] [EC:2.3.1.48]
113048536  [KO:K10151]
113048747  [KO:K06619] [EC:2.7.10.2]
113048774  [KO:K04451]
113048802  [KO:K06671]
113048820  [KO:K10779]
113049056  [KO:K06634]
113049630  [KO:K02202] [EC:2.7.11.22 2.7.11.23]
113049792  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
113049813  [KO:K03359]
113049851  [KO:K05868]
113049853  [KO:K03349]
113050233  [KO:K16197]
113050331  [KO:K02091] [EC:2.7.11.22]
113050507  [KO:K02603]
113050665  [KO:K04402]
113050687  anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
113050797  [KO:K02542] [EC:5.6.2.3]
113051025  [KO:K11268] [EC:2.3.1.-]
113051060  [KO:K06626]
113051292  [KO:K10727]
113051301  [KO:K02537]
113051343  [KO:K09993]
113051383  [KO:K11405] [EC:3.5.1.98]
113051506  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
113051529  [KO:K21770]
113051688  [KO:K02608]
113051723  [KO:K06630]
113051788  [KO:K04503]
113051849  [KO:K02209] [EC:5.6.2.3]
113051906  [KO:K21770]
113052090  [KO:K11584]
113052146  [KO:K21771]
113052344  [KO:K23605]
113052621  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113052649  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113052715  [KO:K06628]
113052758  [KO:K06628]
113053085  [KO:K04683]
113053087  [KO:K03353]
113053287  [KO:K03083] [EC:2.7.11.26]
113053971  [KO:K04382] [EC:3.1.3.16]
113054012  [KO:K04498] [EC:2.3.1.48]
113054041  [KO:K04500]
113054153  [KO:K16198]
113054368  [KO:K06672]
113054538  [KO:K04802]
113054603  [KO:K04802]
113054765  [KO:K04501]
113054912  [KO:K02089] [EC:2.7.11.22]
113055045  [KO:K02213]
113055153  [KO:K04402]
113055829  [KO:K25229]
113055902  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
113056052  [KO:K04498] [EC:2.3.1.48]
113056273  [KO:K06629]
113056284  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
113056315  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
113056677  anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
113056678  [KO:K10292]
113056749  [KO:K26093]
113056814  [KO:K11584]
113057050  [KO:K05866] [EC:3.1.3.48]
113057082  [KO:K06625]
113057262  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
113057597  [KO:K04382] [EC:3.1.3.16]
113057704  [KO:K06635]
113057720  [KO:K06671]
113057740  [KO:K06635]
113058083  [KO:K11479] [EC:2.7.11.1]
113058110  [KO:K02210] [EC:5.6.2.3]
113058175  [KO:K09392]
113058184  [KO:K13375]
113058288  [KO:K16198]
113058475  [KO:K06630]
113058661  [KO:K11267]
113059136  [KO:K04501]
113059198  [KO:K06629]
113059295  [KO:K06670]
113059301  [KO:K06626]
113059726  [KO:K16197]
113059794  tgfb2; transforming growth factor beta-2 [KO:K13376]
113059886  [KO:K06629]
113059945  [KO:K10151]
113060067  [KO:K08866] [EC:2.7.12.1]
113060431  [KO:K13377]
113060625  [KO:K16197]
113061447  [KO:K23605]
113061504  [KO:K06632] [EC:2.7.11.1]
113061851  [KO:K21770]
113061966  [KO:K06643] [EC:2.3.2.27]
113062135  [KO:K06670]
113062321  sgo1; shugoshin 1 isoform X1 [KO:K11580]
113062865  [KO:K16197]
113062942  [KO:K02541] [EC:5.6.2.3]
113063086  [KO:K06624]
113063114  [KO:K16197]
113063203  [KO:K03351]
113063274  [KO:K02541] [EC:5.6.2.3]
113063328  [KO:K06624]
113063372  [KO:K11584]
113063376  [KO:K11584]
113063409  [KO:K11584]
113063465  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
113063657  [KO:K04402]
113063833  [KO:K04382] [EC:3.1.3.16]
113063834  [KO:K03094]
113064224  [KO:K04402]
113064252  [KO:K13375]
113064272  [KO:K03875]
113064276  [KO:K02216] [EC:2.7.11.1]
113064297  rb1; retinoblastoma-associated protein [KO:K06618]
113064541  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113065060  [KO:K04498] [EC:2.3.1.48]
113065081  [KO:K06669]
113065425  [KO:K17454]
113065520  [KO:K06636]
113065815  [KO:K17454]
113065824  [KO:K03357]
113066021  [KO:K03347]
113066038  [KO:K04377]
113066153  [KO:K06671]
113066430  [KO:K09993]
113066613  [KO:K06624]
113066701  [KO:K09993]
113066728  [KO:K04682]
113066870  [KO:K10151]
113066934  [KO:K26117]
113067217  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
113067358  [KO:K04498] [EC:2.3.1.48]
113067596  [KO:K04498] [EC:2.3.1.48]
113067622  [KO:K04498] [EC:2.3.1.48]
113067627  [KO:K04498] [EC:2.3.1.48]
113067941  [KO:K06641] [EC:2.7.11.1]
113067986  [KO:K06672]
113068051  [KO:K16198]
113068151  [KO:K02089] [EC:2.7.11.22]
113068262  [KO:K04501]
113068277  [KO:K16197]
113068515  [KO:K11584]
113068692  [KO:K06636]
113068911  [KO:K10500]
113069258  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
113069319  [KO:K06622]
113069837  [KO:K06622]
113069925  [KO:K03364]
113070371  [KO:K25163]
113070686  [KO:K16197]
113070770  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
113071196  [KO:K11268] [EC:2.3.1.-]
113071551  [KO:K26093]
113071766  [KO:K03354]
113071890  [KO:K04402]
113072476  [KO:K25163]
113072514  [KO:K03357]
113072521  [KO:K06641] [EC:2.7.11.1]
113072569  [KO:K04682]
113073048  [KO:K06672]
113073233  [KO:K06670]
113073417  [KO:K16198]
113073449  [KO:K13728]
113073485  [KO:K06671]
113073748  [KO:K04501]
113074210  [KO:K06636]
113074399  [KO:K06624]
113074527  [KO:K11584]
113074912  [KO:K06625]
113075002  [KO:K25163]
113075876  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113075909  [KO:K25229]
113076323  [KO:K02212] [EC:5.6.2.3]
113076423  [KO:K13728]
113077226  [KO:K13728]
113078257  [KO:K04377]
113078509  [KO:K10292]
113078829  [KO:K12456]
113079160  [KO:K06634]
113079195  [KO:K11273] [EC:3.6.4.13]
113079601  [KO:K03351]
113079751  [KO:K16197]
113079947  [KO:K03347]
113079954  [KO:K02542] [EC:5.6.2.3]
113080394  [KO:K09389]
113080422  [KO:K09389]
113080483  [KO:K02202] [EC:2.7.11.22 2.7.11.23]
113080549  [KO:K02540] [EC:5.6.2.3]
113080847  [KO:K02091] [EC:2.7.11.22]
113080927  [KO:K13728]
113081523  [KO:K11584]
113081661  [KO:K02213]
113081961  [KO:K03456]
113082295  [KO:K03359]
113083587  [KO:K03349]
113083615  [KO:K05868]
113084559  [KO:K06619] [EC:2.7.10.2]
113084856  [KO:K11268] [EC:2.3.1.-]
113084866  tfdp1; transcription factor Dp-1 [KO:K04683]
113085488  [KO:K02210] [EC:5.6.2.3]
113086291  [KO:K17390]
113089457  orc4; origin recognition complex subunit 4 [KO:K02606]
113090170  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
113091106  [KO:K06627]
113091288  [KO:K04451]
113091369  [KO:K06671]
113091445  [KO:K06067] [EC:3.5.1.98]
113091947  [KO:K25229]
113092285  [KO:K12456]
113092747  esco1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
113092828  [KO:K02212] [EC:5.6.2.3]
113092982  [KO:K25163]
113093387  [KO:K02542] [EC:5.6.2.3]
113093854  [KO:K06631] [EC:2.7.11.21]
113094117  [KO:K11584]
113094395  espl1; separin [KO:K02365] [EC:3.4.22.49]
113094561  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
113094957  [KO:K04402]
113094959  [KO:K04402]
113095125  [KO:K06679]
113096148  [KO:K04498] [EC:2.3.1.48]
113096367  [KO:K04402]
113097371  [KO:K23605]
113097398  [KO:K04501]
113097486  [KO:K02091] [EC:2.7.11.22]
113097725  [KO:K04402]
113098409  [KO:K17390]
113098462  [KO:K11584]
113098897  [KO:K04451]
113100352  [KO:K11273] [EC:3.6.4.13]
113100766  [KO:K02603]
113100957  [KO:K02540] [EC:5.6.2.3]
113103149  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
113103384  [KO:K16197]
113105376  [KO:K04685]
113105735  [KO:K21771]
113105825  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
113105943  [KO:K21770]
113106009  [KO:K23605]
113106164  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
113106177  [KO:K02608]
113106212  [KO:K06626]
113106244  [KO:K09993]
113106316  [KO:K11405] [EC:3.5.1.98]
113106332  [KO:K02537]
113106342  cdt1; DNA replication factor Cdt1 [KO:K10727]
113106398  [KO:K06630]
113106505  [KO:K04503]
113106863  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113107067  [KO:K06622]
113107169  [KO:K03354]
113107231  fzr1; fizzy-related protein homolog [KO:K03364]
113107327  [KO:K16197]
113107679  [KO:K04402]
113107680  [KO:K11267]
113108074  [KO:K06671]
113108120  [KO:K06636]
113108137  [KO:K04683]
113108140  [KO:K03353]
113108143  [KO:K04685]
113108150  [KO:K06671]
113108334  [KO:K11267]
113108473  [KO:K04683]
113108476  [KO:K03353]
113108968  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113109282  [KO:K11542]
113109436  [KO:K04500]
113109519  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113109588  [KO:K06679]
113109601  [KO:K04500]
113109975  [KO:K06672]
113110038  ccna1; cyclin-A1 [KO:K06627]
113110084  [KO:K04501]
113110142  [KO:K04501]
113110310  [KO:K04802]
113110421  [KO:K16198]
113110695  [KO:K04402]
113110760  [KO:K04402]
113110768  [KO:K02213]
113111275  [KO:K02604]
113111276  [KO:K02604]
113111502  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
113111711  [KO:K04498] [EC:2.3.1.48]
113111871  [KO:K25163]
113112130  [KO:K06629]
113112293  [KO:K10292]
113112462  [KO:K11584]
113112611  [KO:K26093]
113112901  [KO:K05866] [EC:3.1.3.48]
113113055  [KO:K11584]
113113200  [KO:K03347]
113113384  [KO:K10779]
113113397  [KO:K10779]
113113477  [KO:K06620]
113113758  [KO:K13376]
113113899  [KO:K06635]
113114011  [KO:K04382] [EC:3.1.3.16]
113114049  [KO:K06627]
113114191  [KO:K06671]
113114374  [KO:K02210] [EC:5.6.2.3]
113114393  [KO:K11479] [EC:2.7.11.1]
113114394  [KO:K11479] [EC:2.7.11.1]
113114643  [KO:K04402]
113114684  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
113114777  [KO:K11267]
113115032  ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
113115100  [KO:K03456]
113115230  [KO:K16198]
113115342  [KO:K03363]
113115344  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
113115360  [KO:K09392]
113115386  [KO:K13375]
113115552  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
113115690  [KO:K06670]
113115767  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
113115859  [KO:K06629]
113116316  mtbp; mdm2-binding protein isoform X1 [KO:K26116]
113116461  [KO:K06671]
113116533  [KO:K13376]
113116552  ttk; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
113116616  [KO:K04501]
113116718  [KO:K16197]
113116939  [KO:K13377]
113116994  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
113117193  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
113117220  [KO:K09389]
113117372  [KO:K16197]
113117373  [KO:K16197]
113117431  [KO:K25163]
113117807  [KO:K06637] [EC:2.7.11.1]
113118159  [KO:K04682]
113118297  [KO:K04377]
113118304  [KO:K06632] [EC:2.7.11.1]
113118366  [KO:K23605]
113118384  [KO:K06632] [EC:2.7.11.1]
113118589  [KO:K21770]
113118744  [KO:K05868]
113119189  [KO:K16197]
113119205  [KO:K04501]
113119276  [KO:K06670]
113119377  [KO:K02091] [EC:2.7.11.22]
113119549  [KO:K06620]
113119558  [KO:K06067] [EC:3.5.1.98]
113119567  [KO:K04402]
113120243  [KO:K06626]
113120441  [KO:K11268] [EC:2.3.1.-]
113120842  [KO:K02541] [EC:5.6.2.3]
113120867  [KO:K16197]
113121039  [KO:K11584]
113121222  [KO:K11584]
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Related
pathway
caua03030  DNA replication
caua04010  MAPK signaling pathway
caua04120  Ubiquitin mediated proteolysis
caua04210  Apoptosis
KO pathway
ko04110   

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