KEGG   PATHWAY: ccad04720
Entry
ccad04720                   Pathway                                
Name
Long-term potentiation - Cervus canadensis (wapiti)
Description
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class
Organismal Systems; Nervous system
Pathway map
ccad04720  Long-term potentiation
ccad04720

Other DBs
GO: 0048169
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122420171  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122420753  [KO:K02183]
122420755  CALM3; calmodulin-3 [KO:K02183]
122421596  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
122422042  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122422203  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122423084  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122423237  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
122423576  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
122423671  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122423876  KRAS; GTPase KRas isoform X1 [KO:K07827]
122423939  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122424089  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122424343  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122424748  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122425059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122426433  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122427076  RAP1B; ras-related protein Rap-1b [KO:K07836]
122427430  PPP1R1A; protein phosphatase 1 regulatory subunit 1A isoform X1 [KO:K08050]
122427721  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
122430147  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122430651  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122430818  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
122430926  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
122431708  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431959  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122432734  [KO:K04498] [EC:2.3.1.48]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122433081  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122433444  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
122434178  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122434217  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
122434323  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122434589  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122435222  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
122435331  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122435753  [KO:K06269] [EC:3.1.3.16]
122435924  NRAS; GTPase NRas [KO:K07828]
122436539  RAP1A; ras-related protein Rap-1A [KO:K04353]
122436774  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122438514  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122438529  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122438725  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122439461  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
122439666  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
122439705  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122440096  [KO:K06269] [EC:3.1.3.16]
122440231  [KO:K04369] [EC:2.7.12.2]
122440547  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122440910  [KO:K04369] [EC:2.7.12.2]
122441648  CALM2; calmodulin-2 [KO:K02183]
122441856  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
122441910  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122442399  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122443081  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122443383  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122443955  CALM1; calmodulin-1 isoform X1 [KO:K02183]
122444829  [KO:K04374]
122445547  [KO:K02183]
122446047  [KO:K07827]
122446062  [KO:K04369] [EC:2.7.12.2]
122446388  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122446399  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122447261  [KO:K04371] [EC:2.7.11.24]
122448285  [KO:K02183]
122448380  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448381  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448900  [KO:K02183]
122451315  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122451732  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
122453031  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122453208  [KO:K02183]
122453582  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00305  Magnesium cation
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
Reference
PMID:15652868
  Authors
Blitzer RD, Iyengar R, Landau EM.
  Title
Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
  Journal
Biol Psychiatry 57:113-9 (2005)
DOI:10.1016/j.biopsych.2004.02.031
Reference
PMID:10652548
  Authors
Soderling TR, Derkach VA.
  Title
Postsynaptic protein phosphorylation and LTP.
  Journal
Trends Neurosci 23:75-80 (2000)
DOI:10.1016/S0166-2236(99)01490-3
Reference
PMID:11378299
  Authors
Poser S, Storm DR.
  Title
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
  Journal
Int J Dev Neurosci 19:387-94 (2001)
DOI:10.1016/S0736-5748(00)00094-0
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
  Authors
Purves D, Augustine GJ (ed).
  Title
Neuroscience
  Journal
Sunderland, Mass.:Sinauer Associates (2004)
Reference
PMID:14715912
  Authors
Lynch MA.
  Title
Long-term potentiation and memory.
  Journal
Physiol Rev 84:87-136 (2004)
DOI:10.1152/physrev.00014.2003
Reference
PMID:15857686
  Authors
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
  Title
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
  Journal
Brain Res Mol Brain Res 135:232-48 (2005)
DOI:10.1016/j.molbrainres.2004.12.018
Reference
PMID:9697848
  Authors
Berridge MJ.
  Title
Neuronal calcium signaling.
  Journal
Neuron 21:13-26 (1998)
DOI:10.1016/S0896-6273(00)80510-3
Related
pathway
ccad04010  MAPK signaling pathway
ccad04020  Calcium signaling pathway
ccad04724  Glutamatergic synapse
KO pathway
ko04720   

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