KEGG   PATHWAY: ccad04020
Entry
ccad04020                   Pathway                                
Name
Calcium signaling pathway - Cervus canadensis (wapiti)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ccad04020  Calcium signaling pathway
ccad04020

Other DBs
GO: 0019722
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122419704  ADORA2A; adenosine receptor A2a [KO:K04266]
122419734  [KO:K04809]
122419908  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
122420118  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
122420171  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122420263  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
122420334  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
122420566  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
122420753  [KO:K02183]
122420755  CALM3; calmodulin-3 [KO:K02183]
122420851  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122421017  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
122421038  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
122421548  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
122421593  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
122421596  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
122421659  FGF21; fibroblast growth factor 21 [KO:K22429]
122421666  PHKB; phosphorylase B kinase regulatory subunit beta isoform X1 [KO:K07190]
122422042  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122422068  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
122422139  C19H4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
122422171  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122422203  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122422230  CCKAR; cholecystokinin receptor type A [KO:K04194]
122422257  TACR3; neuromedin-K receptor [KO:K04224]
122422595  [KO:K23449]
122422712  [KO:K23449]
122422859  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
122422924  PLN; cardiac phospholamban [KO:K05852]
122423082  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122423224  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
122423660  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
122423671  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
122423683  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122423712  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
122423748  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
122423849  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
122423939  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122424008  FGF23; fibroblast growth factor 23 [KO:K22428]
122424018  FGF6; fibroblast growth factor 6 [KO:K04358]
122424089  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122424243  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122424245  OXTR; oxytocin receptor [KO:K04229]
122424343  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122424472  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
122424606  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
122424654  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122424724  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
122424748  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122424754  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
122424811  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
122424819  HRH1; histamine H1 receptor [KO:K04149]
122424987  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
122425388  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122425491  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
122426036  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
122426166  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
122426178  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
122426466  ERBB4; receptor tyrosine-protein kinase ErbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122426625  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
122427060  ERBB3; receptor tyrosine-protein kinase ErbB-3 [KO:K05084] [EC:2.7.10.1]
122427429  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
122427609  AVPR1A; vasopressin V1a receptor [KO:K04226]
122427749  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
122427991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122428025  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122428068  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122428216  FGF5; fibroblast growth factor 5 [KO:K04358]
122428245  DRD5; D(1B) dopamine receptor [KO:K05840]
122428274  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122429439  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122429511  TFEB; transcription factor EB [KO:K15590]
122429898  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
122430147  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
122430651  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
122430796  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122430873  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
122430926  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
122430960  CASQ1; calsequestrin-1 [KO:K23468]
122431192  FGF3; fibroblast growth factor 3 [KO:K04358]
122431275  FGF19; fibroblast growth factor 19 [KO:K22603]
122431344  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
122431410  FGF4; fibroblast growth factor 4 [KO:K04358]
122431666  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122431708  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431778  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122431820  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
122431856  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
122431869  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122431958  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
122431959  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122432225  VEGFC; vascular endothelial growth factor C [KO:K05449]
122432228  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122432310  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
122432435  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122432473  FGF20; fibroblast growth factor 20 [KO:K04358]
122432611  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
122432769  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
122432793  PHKG1; phosphorylase B kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
122432975  ORAI3; protein orai-3 [KO:K16058]
122433072  PHKG2; phosphorylase B kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
122433081  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122433117  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122433132  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122433444  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
122433596  ORAI2; protein orai-2 [KO:K16057]
122433616  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
122434178  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122434337  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
122434361  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
122434625  PHKA1; phosphorylase B kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
122434746  VEGFD; vascular endothelial growth factor D [KO:K05449]
122434753  PHKA2; phosphorylase B kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
122434769  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122434822  GRPR; gastrin-releasing peptide receptor [KO:K04169]
122434863  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
122435222  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
122435311  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
122435791  CASQ2; calsequestrin-2 [KO:K23445]
122435827  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
122435828  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
122435907  FGF16; fibroblast growth factor 16 [KO:K04358]
122436757  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
122436758  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
122436774  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122436788  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
122436817  SMIM6; small integral membrane protein 6 [KO:K26468]
122436829  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
122437088  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
122438015  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
122438250  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122438342  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
122438414  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
122438514  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
122438529  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122438688  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
122439461  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
122439526  [KO:K26467]
122439616  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
122439705  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
122439706  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122439736  ADRB2; beta-2 adrenergic receptor [KO:K04142]
122439737  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
122439770  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122439923  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122440044  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122440202  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
122440204  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
122440205  TBXA2R; thromboxane A2 receptor [KO:K04264]
122440293  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
122440368  MCOLN1; mucolipin-1 [KO:K04992]
122440510  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
122440547  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122440558  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
122440569  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122441461  TACR1; substance-P receptor [KO:K04222]
122441530  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
122441603  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
122441648  CALM2; calmodulin-2 [KO:K02183]
122441659  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
122441856  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
122441999  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122442295  [KO:K05094] [EC:2.7.10.1]
122442399  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
122442448  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
122442971  HRH2; histamine H2 receptor [KO:K04150]
122442975  DRD1; D(1A) dopamine receptor [KO:K04144]
122442989  F2R; proteinase-activated receptor 1 [KO:K03914]
122443081  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122443145  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
122443147  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
122443152  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
122443334  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
122443335  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
122443383  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122443422  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
122443431  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122443630  FGF7; fibroblast growth factor 7 [KO:K04358]
122443804  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
122443955  CALM1; calmodulin-1 isoform X1 [KO:K02183]
122444227  [KO:K10784]
122444644  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122444716  ADORA2B; adenosine receptor A2b [KO:K04267]
122445077  AGTR1; type-1 angiotensin II receptor [KO:K04166]
122445547  [KO:K02183]
122445860  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122446118  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
122446136  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122446158  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
122446361  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
122446388  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122446399  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122446414  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
122446452  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
122446472  TACR2; substance-K receptor isoform X1 [KO:K04223]
122446543  MRLN; myoregulin [KO:K22643]
122446563  ADRB1; beta-1 adrenergic receptor [KO:K04141]
122446587  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
122446823  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122446827  RYR2; ryanodine receptor 2 [KO:K04962]
122447130  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122447200  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
122447232  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
122447252  P2RX1; P2X purinoceptor 1 [KO:K05215]
122447444  EDNRB; endothelin receptor type B [KO:K04198]
122447460  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
122447498  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
122447526  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
122448285  [KO:K02183]
122448362  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
122448380  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448381  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
122448432  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
122448601  NTSR1; neurotensin receptor type 1 [KO:K04211]
122448612  [KO:K04632]
122448614  [KO:K04632]
122448615  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122448629  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
122448638  TNNC2; troponin C, skeletal muscle [KO:K12042]
122448704  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
122448844  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122448900  [KO:K02183]
122449419  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
122449654  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122449762  P2RX3; P2X purinoceptor 3 [KO:K05217]
122450278  SLN; sarcolipin [KO:K22642]
122450372  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
122451067  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
122451120  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
122451315  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122451657  ITPKB; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
122451732  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
122451771  AVPR1B; vasopressin V1b receptor [KO:K04227]
122451896  EDNRA; endothelin-1 receptor [KO:K04197]
122452067  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
122452261  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122452317  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122452370  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
122453006  [KO:K04636]
122453031  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122453090  [KO:K05126] [EC:2.7.10.1]
122453183  FGF2; fibroblast growth factor 2 [KO:K18497]
122453208  [KO:K02183]
122453611  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122453829  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
122453854  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
122453991  [KO:K04161]
122454210  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122454307  [KO:K04632]
122454543  FGF10; fibroblast growth factor 10 [KO:K04358]
122454583  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122454587  FGF18; fibroblast growth factor 18 [KO:K04358]
122455040  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
122455108  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
122455157  BDKRB1; B1 bradykinin receptor [KO:K03915]
122455158  BDKRB2; B2 bradykinin receptor [KO:K03916]
122455321  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ccad04010  MAPK signaling pathway
ccad04070  Phosphatidylinositol signaling system
ccad04210  Apoptosis
ccad04720  Long-term potentiation
ccad04730  Long-term depression
KO pathway
ko04020   

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