KEGG   PATHWAY: ccad04010
Entry
ccad04010                   Pathway                                
Name
MAPK signaling pathway - Cervus canadensis (wapiti)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccad04010  MAPK signaling pathway
ccad04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122419705  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
122420110  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122420171  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
122420207  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
122420210  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
122420211  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
122420314  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
122420335  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122420799  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
122420851  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122420917  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
122420963  NTF4; neurotrophin-4 [KO:K12457]
122421012  RRAS; ras-related protein R-Ras [KO:K07829]
122421130  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
122421252  RELB; transcription factor RelB [KO:K09253]
122421659  FGF21; fibroblast growth factor 21 [KO:K22429]
122421734  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
122422041  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122422171  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122422203  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122422588  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122423082  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122423084  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122423115  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
122423229  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122423255  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
122423291  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
122423293  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122423457  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
122423465  [KO:K03283]
122423529  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122423531  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122423661  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122423876  KRAS; GTPase KRas isoform X1 [KO:K07827]
122424005  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
122424008  FGF23; fibroblast growth factor 23 [KO:K22428]
122424015  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
122424018  FGF6; fibroblast growth factor 6 [KO:K04358]
122424072  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122424089  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
122424243  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122424266  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122424283  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122424421  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
122424543  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
122424547  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
122424595  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
122424654  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
122424694  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
122424725  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
122424748  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122424834  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122425059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122425388  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
122426316  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122426433  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
122426466  ERBB4; receptor tyrosine-protein kinase ErbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122426475  STMN1; stathmin [KO:K04381]
122426490  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
122426807  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122427060  ERBB3; receptor tyrosine-protein kinase ErbB-3 [KO:K05084] [EC:2.7.10.1]
122427076  RAP1B; ras-related protein Rap-1b [KO:K07836]
122427126  KITLG; kit ligand isoform X1 [KO:K05461]
122427135  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122427248  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
122427363  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
122427416  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
122427453  [KO:K04370]
122427504  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122427765  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
122427841  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
122427991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122428005  [KO:K04430] [EC:2.7.12.2]
122428017  EREG; proepiregulin [KO:K09784]
122428025  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122428068  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122428193  [KO:K03283]
122428200  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122428214  AREG; amphiregulin [KO:K09782]
122428216  FGF5; fibroblast growth factor 5 [KO:K04358]
122428339  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122429019  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122429095  DAXX; death domain-associated protein 6 [KO:K02308]
122429123  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122429143  SRF; serum response factor [KO:K04378]
122429439  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122429963  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122430072  TNF; tumor necrosis factor [KO:K03156]
122430139  [KO:K03283]
122430140  [KO:K03283]
122430141  [KO:K03283]
122430152  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122430632  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122430687  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
122430781  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
122430796  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122430799  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
122430838  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122430978  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
122430981  INS; insulin [KO:K04526]
122430989  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
122430996  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
122431192  FGF3; fibroblast growth factor 3 [KO:K04358]
122431275  FGF19; fibroblast growth factor 19 [KO:K22603]
122431410  FGF4; fibroblast growth factor 4 [KO:K04358]
122431666  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122431708  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122431778  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122431869  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122431959  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
122432031  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
122432225  VEGFC; vascular endothelial growth factor C [KO:K05449]
122432228  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122432443  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
122432459  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122432473  FGF20; fibroblast growth factor 20 [KO:K04358]
122432503  ANGPT2; angiopoietin-2 [KO:K05466]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122432667  EFNA1; ephrin-A1 [KO:K05462]
122432713  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
122432722  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
122432743  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
122432932  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122433081  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122433117  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
122433132  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122433157  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
122433170  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
122433179  HSPB1; heat shock protein beta-1 [KO:K04455]
122433321  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122433842  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
122433913  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122434125  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
122434217  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
122434303  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122434323  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
122434434  FLNA; filamin-A isoform X1 [KO:K04437]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122434589  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122434746  VEGFD; vascular endothelial growth factor D [KO:K05449]
122434769  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
122434868  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
122435331  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
122435585  [KO:K17534] [EC:2.7.11.25]
122435827  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
122435907  FGF16; fibroblast growth factor 16 [KO:K04358]
122435924  NRAS; GTPase NRas [KO:K07828]
122435935  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
122436539  RAP1A; ras-related protein Rap-1A [KO:K04353]
122436569  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122436698  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122436774  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
122436847  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
122436906  JUN; transcription factor AP-1 [KO:K04448]
122436945  [KO:K04381]
122437024  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
122437089  ARTN; artemin isoform X1 [KO:K25415]
122438248  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
122438250  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122438342  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
122438676  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122438725  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122438934  [KO:K07830]
122439478  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
122439544  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122439554  RASA1; ras GTPase-activating protein 1 [KO:K04352]
122439575  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
122439701  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
122439706  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122439712  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
122439770  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122439825  CD14; monocyte differentiation antigen CD14 [KO:K04391]
122439964  EFNA2; ephrin-A2 [KO:K05462]
122440039  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
122440044  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122440161  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
122440181  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
122440231  [KO:K04369] [EC:2.7.12.2]
122440265  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
122440279  NRTN; neurturin [KO:K25414]
122440295  PSPN; persephin [KO:K25416]
122440347  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122440366  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122440384  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
122440510  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
122440547  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122440569  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122440572  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122440745  JUND; transcription factor jun-D [KO:K04449]
122440859  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
122440910  [KO:K04369] [EC:2.7.12.2]
122441358  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122441432  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
122441438  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
122441530  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
122441553  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
122441591  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122441596  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
122441629  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
122441784  IL1B; interleukin-1 beta [KO:K04519]
122441856  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
122442295  [KO:K05094] [EC:2.7.10.1]
122442423  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
122442448  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
122442617  IL1A; interleukin-1 alpha [KO:K04383]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122443065  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122443078  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122443362  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
122443430  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
122443431  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
122443435  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
122443464  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122443630  FGF7; fibroblast growth factor 7 [KO:K04358]
122443696  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
122443717  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
122443760  MAX; protein max isoform X1 [KO:K04453]
122443814  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
122443865  PGF; placenta growth factor isoform X1 [KO:K16859]
122443873  FOS; proto-oncogene C-Fos [KO:K04379]
122443885  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
122443960  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
122444120  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
122444121  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
122444207  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
122444682  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
122444794  [KO:K04723]
122444829  [KO:K04374]
122444838  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
122444956  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
122445001  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122445254  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
122445280  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
122445826  TP53; cellular tumor antigen P53 [KO:K04451]
122445860  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122445978  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122446047  [KO:K07827]
122446062  [KO:K04369] [EC:2.7.12.2]
122446136  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122446181  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
122446321  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122446398  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
122446399  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122446496  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122446640  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
122446823  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122447130  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122447261  [KO:K04371] [EC:2.7.11.24]
122447460  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
122447566  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122447839  CRK; adapter molecule crk isoform X1 [KO:K04438]
122448067  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
122448124  STK4; serine/threonine-protein kinase 4 [KO:K04411]
122448146  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
122448336  [KO:K04381]
122448466  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
122448519  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
122448564  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
122448567  [KO:K04392]
122448607  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
122448723  NF1; neurofibromin isoform X1 [KO:K08052]
122449456  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
122449478  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
122449591  RRAS2; ras-related protein R-Ras2 [KO:K07830]
122449654  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122449806  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122449871  [KO:K04453]
122450003  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
122450010  [KO:K03283]
122450381  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
122451126  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122451212  MYC; myc proto-oncogene protein [KO:K04377]
122451521  STK3; serine/threonine-protein kinase 3 [KO:K04412]
122451946  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
122452022  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
122452049  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
122452220  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
122452261  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
122452317  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122452400  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
122452409  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122452906  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122453090  [KO:K05126] [EC:2.7.10.1]
122453183  FGF2; fibroblast growth factor 2 [KO:K18497]
122453210  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
122453356  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
122453548  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122453611  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122453844  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
122453931  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
122453995  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
122454160  [KO:K04381]
122454236  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
122454393  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122454543  FGF10; fibroblast growth factor 10 [KO:K04358]
122454583  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122454587  FGF18; fibroblast growth factor 18 [KO:K04358]
122454848  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122455174  CRKL; crk-like protein [KO:K04438]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ccad04070  Phosphatidylinositol signaling system
ccad04110  Cell cycle
ccad04115  p53 signaling pathway
ccad04210  Apoptosis
ccad04310  Wnt signaling pathway
ccad04668  TNF signaling pathway
KO pathway
ko04010   

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