KEGG   PATHWAY: cery04270
Entry
cery04270                   Pathway                                
Name
Vascular smooth muscle contraction - Chanodichthys erythropterus (predatory carp)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
cery04270  Vascular smooth muscle contraction
cery04270

Other DBs
GO: 0014829
Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002209  edn1; endothelin-1 [KO:K16366]
137002321  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
137002384  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
137002428  agtr1a; type-1 angiotensin II receptor B [KO:K04166]
137002546  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
137002583  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137002819  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
137002841  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
137002995  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
137003510  kcnmb3; calcium-activated potassium channel subunit beta-3 [KO:K04939]
137003691  kcnmb2a; calcium-activated potassium channel subunit beta-2 [KO:K04938]
137003897  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
137004239  [KO:K12319] [EC:4.6.1.2]
137004281  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
137004506  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
137004569  ppp1r14ab; protein phosphatase 1, regulatory (inhibitor) subunit 14Ab [KO:K12328]
137004899  gucy1a2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
137005034  ptgir; prostacyclin receptor [KO:K04263]
137005312  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
137006192  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137006273  pla2g4f.2; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
137006304  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
137006570  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
137006597  calm1a; calmodulin-1a [KO:K02183]
137006766  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
137007131  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
137007133  plcb4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
137007404  prkg1b; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
137007459  [KO:K04936]
137007775  acta2; actin, aortic smooth muscle isoform X1 [KO:K12313]
137007778  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
137007889  gna13a; guanine nucleotide-binding protein subunit alpha-13a [KO:K04639]
137008213  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
137008347  prkcea; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
137008686  nppcl2; C-type natriuretic peptide 2 [KO:K12336]
137008821  [KO:K12324] [EC:4.6.1.2]
137008864  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
137008899  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
137008921  ednrab; endothelin receptor type Ab [KO:K04197]
137008930  adcy6b; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
137008984  [KO:K12329]
137009428  calcrl2; calcitonin gene-related peptide type 1 receptor [KO:K04577]
137009724  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
137009750  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
137009798  rhoac; rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
137009849  edn3b; endothelin-3b [KO:K05227]
137009886  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
137010674  myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
137010684  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
137010730  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
137010734  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
137010777  mylkb; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
137010794  itpr1a; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 [KO:K04958]
137010997  calcrlb; calcitonin gene-related peptide type 1 receptor [KO:K04577]
137011308  myh11a; myosin-11a isoform X1 [KO:K10352]
137011321  rhoca; ras homolog family member Ca [KO:K04513]
137011469  myh10; myosin-10 isoform X1 [KO:K10352]
137011597  myh9a; myosin-9a isoform X1 [KO:K10352]
137011695  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
137011708  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
137012602  adora2ab; adenosine A2a receptor b [KO:K04266]
137012642  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
137012773  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
137012782  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
137013965  [KO:K08449]
137014137  [KO:K08447]
137014328  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
137014515  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
137014601  cald1b; caldesmon 1b isoform X1 [KO:K12327]
137015018  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
137015312  [KO:K12332]
137015355  lsp1a; non-muscle caldesmon isoform X1 [KO:K12327]
137015576  calml4b; calmodulin-like protein 4 [KO:K02183]
137017171  [KO:K10352]
137017251  [KO:K08049] [EC:4.6.1.1]
137017306  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
137017505  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
137017563  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
137017579  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
137017689  ramp2; receptor activity-modifying protein 2 [KO:K08448]
137017705  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
137017725  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
137017790  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
137018000  prkcab; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
137018534  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
137018599  [KO:K08043] [EC:4.6.1.1]
137018759  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
137018855  prkchb; protein kinase C, eta, b isoform X1 [KO:K18051] [EC:2.7.11.13]
137018973  mylk4b; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
137019056  rock2b; rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.39]
137019074  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
137019114  si:ch211-202p1.5; endothelin-2 [KO:K16367]
137019294  plcb4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
137019295  plcb1l; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
137019367  calm1b; calmodulin-1b [KO:K02183]
137019441  [KO:K06269] [EC:3.1.3.16]
137020403  kcnma1a; calcium-activated potassium channel subunit alpha-1a isoform X1 [KO:K04936]
137020525  agt; angiotensinogen [KO:K09821]
137020648  prkcha; protein kinase C eta type [KO:K18051] [EC:2.7.11.13]
137020656  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
137020744  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
137020863  prkg1a; cGMP-dependent protein kinase 1a isoform X1 [KO:K07376] [EC:2.7.11.12]
137020871  prkceb; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
137020876  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
137021134  s100p; calcium-activated potassium channel subunit beta-2 isoform X1 [KO:K04938]
137021437  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
137021452  itpr1b; inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 isoform X1 [KO:K04958]
137021605  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
137021706  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
137021723  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
137021787  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
137021860  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
137022730  adm2b; protein ADM2 [KO:K25343]
137023308  itpr2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
137023351  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
137023807  avpr1ab; arginine vasopressin receptor 1Ab [KO:K04226]
137024286  cald1a; caldesmon 1a isoform X1 [KO:K12327]
137024315  adm2a; protein ADM2a [KO:K25343]
137024359  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
137024507  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
137024536  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
137024583  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
137024677  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
137025670  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
137026184  avp; vasopressin-neurophysin 2-copeptin [KO:K05242]
137026362  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
137026460  [KO:K01047] [EC:3.1.1.4]
137026591  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
137026624  nppa; natriuretic peptides A [KO:K12334]
137026626  nppal; natriuretic peptide A-like [KO:K12336]
137026710  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
137026728  [KO:K16367]
137026821  adra1aa; adrenoceptor alpha 1Aa isoform X1 [KO:K04135]
137026918  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
137027010  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
137027080  adora2aa; adenosine A2a receptor a [KO:K04266]
137027114  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
137027151  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
137027153  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
137027228  [KO:K01047] [EC:3.1.1.4]
137027768  gna11a; guanine nucleotide-binding protein subunit alpha-11a isoform X1 [KO:K04634]
137027823  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
137028142  [KO:K12324] [EC:4.6.1.2]
137028262  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
137028389  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
137028439  [KO:K04513]
137029007  nppc; C-type natriuretic peptide [KO:K12336]
137029043  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
137029156  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
137029364  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
137029419  [KO:K04266]
137029451  [KO:K07376] [EC:2.7.11.12]
137029951  arhgef11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
137029986  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
137030143  [KO:K06269] [EC:3.1.3.16]
137030525  calca; calcitonin/calcitonin-related polypeptide, alpha isoform X1 [KO:K12332]
137030796  mrvi1; uncharacterized protein mrvi1 [KO:K12337]
137030962  adma; adrenomedullin a [KO:K12333]
137031154  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
137031262  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
137031340  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
137031374  calml4a; calmodulin-like protein 4a [KO:K02183]
137031570  ednraa; endothelin receptor type Aa [KO:K04197]
137031862  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
137032252  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
137032321  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
137032583  pla2g12a; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
137032899  adra1d; alpha-1A adrenergic receptor [KO:K04137]
137033110  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
137033557  arhgef12b; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
137033586  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
137033643  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
137033785  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
137033892  [KO:K16342] [EC:3.1.1.4]
137033991  [KO:K16342] [EC:3.1.1.4]
137034085  [KO:K16342] [EC:3.1.1.4]
137034359  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
137034415  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
137034657  npr1b; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
137034764  adora2b; adenosine receptor A2b [KO:K04267]
137034850  ppp1r14aa; protein phosphatase 1, regulatory (inhibitor) subunit 14Aa [KO:K12328]
137035008  [KO:K16342] [EC:3.1.1.4]
137035015  [KO:K16342] [EC:3.1.1.4]
137035016  [KO:K16342] [EC:3.1.1.4]
137035017  [KO:K16342] [EC:3.1.1.4]
137035018  [KO:K16342] [EC:3.1.1.4]
137035020  [KO:K16342] [EC:3.1.1.4]
137035021  [KO:K16342] [EC:3.1.1.4]
137035022  [KO:K16342] [EC:3.1.1.4]
137035023  [KO:K16342] [EC:3.1.1.4]
137035024  [KO:K16342] [EC:3.1.1.4]
137035025  [KO:K16342] [EC:3.1.1.4]
137035029  [KO:K16342] [EC:3.1.1.4]
137035030  [KO:K16342] [EC:3.1.1.4]
137035031  [KO:K16342] [EC:3.1.1.4]
137035275  arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
137035387  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
137035737  calcrla; calcitonin gene-related peptide type 1 receptor [KO:K04577]
137035888  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
137036010  ramp1; receptor activity-modifying protein 1 [KO:K08447]
137037626  npr1a; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
137037709  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
137037778  edn2; endothelin-2 [KO:K16367]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
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Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
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Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
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Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
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Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
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Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
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Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
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Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
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Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
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J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
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Ko EA, Han J, Jung ID, Park WS
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Physiological roles of K+ channels in vascular smooth muscle cells.
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J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
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PMID:18703404
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Woodard GE, Rosado JA
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Natriuretic peptides in vascular physiology and pathology.
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Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
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Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
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Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
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Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
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PMID:15725705
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Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
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J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
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PMID:9458738
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Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
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Am J Physiol 274:C282-8 (1998)
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Reference
PMID:12060106
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Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
cery00590  Arachidonic acid metabolism
cery04020  Calcium signaling pathway
KO pathway
ko04270   

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