Entry Name Toll-like receptor signaling pathway - Chanodichthys erythropterus (predatory carp)
Description Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map cery04620 Toll-like receptor signaling pathway
Organism Chanodichthys erythropterus (predatory carp) [GN:
cery ]
Gene 137003113 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
137004124 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
137006187 nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734 ]
137007833 map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
137008719 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
137009461 cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
137009787 zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
137011430 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
137011712 stat2; signal transducer and activator of transcription 2 [KO:K11221 ]
137011727 pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649 ]
137013841 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
137017221 map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
137017996 rac1b; ras-related C3 botulinum toxin substrate 1b isoform X1 [KO:K04392 ]
137018733 nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734 ]
137019192 fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379 ]
137019429 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
137020384 tlr4bb; toll-like receptor 4b, duplicate b isoform X1 [KO:K10160 ]
137021461 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
137023050 tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
137027661 stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220 ]
137034610 june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448 ]
137035124 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
137037220 tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156 ]
Reference Authors Kawai T, Akira S.
Title TLR signaling.
Journal Reference Authors O'Neill LA, Bowie AG.
Title The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
Journal Reference Authors Honda K, Taniguchi T.
Title IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and Type I interferons.
Journal Reference Authors Akira S, Uematsu S, Takeuchi O.
Title Pathogen recognition and innate immunity.
Journal Reference Authors Yamamoto M, Takeda K, Akira S.
Title TIR domain-containing adaptors define the specificity of TLR signaling.
Journal Reference Authors Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
Title The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
Journal Reference Authors Aderem A, Smith KD.
Title A systems approach to dissecting immunity and inflammation.
Journal Reference Authors Banerjee A, Gerondakis S.
Title Coordinating TLR-activated signaling pathways in cells of the immune system.
Journal Reference Authors Loniewski KJ, Patial S, Parameswaran N.
Title Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
Journal Reference Authors Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
Title Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and innate immunity.
Journal Related cery04060 Cytokine-cytokine receptor interaction
KO pathway
