KEGG   PATHWAY: cery04060
Entry
cery04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Chanodichthys erythropterus (predatory carp)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cery04060  Cytokine-cytokine receptor interaction
cery04060

Organism
Chanodichthys erythropterus (predatory carp) [GN:cery]
Gene
137002073  bmp8a; bone morphogenetic protein 8A [KO:K16622]
137002101  il6; interleukin-6 [KO:K05405]
137002390  tgfbr1a; TGF-beta receptor type-1a isoform X1 [KO:K04674] [EC:2.7.11.30]
137002588  acvr1l; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
137002709  ccr9a; C-C chemokine receptor type 9a [KO:K04184]
137002910  ebi3; interleukin-27 subunit beta [KO:K24476]
137002933  ccl25a; C-C motif chemokine 21 [KO:K13072]
137002962  thpo; thrombopoietin isoform X1 [KO:K06854]
137003052  [KO:K13596] [EC:2.7.11.30]
137003259  [KO:K04193]
137003269  inhbab; inhibin subunit beta Ab [KO:K04667]
137003330  ccl20a.3; C-C motif chemokine 20a.3 [KO:K14625]
137003339  [KO:K05504]
137003480  [KO:K04193]
137003485  ccl20l; C-C motif chemokine 20 [KO:K14625]
137003499  xcr1b.2; chemokine XC receptor 1 [KO:K04193]
137003663  admp; anti-dorsalizing morphogenic protein [KO:K21283]
137003679  crfb16; cytokine receptor family member B16 [KO:K05137]
137003686  ackr4a; atypical chemokine receptor 4 isoform X1 [KO:K04186]
137003712  zmp:0000001127; interleukin-12 subunit alpha [KO:K05406]
137004108  gdf9; growth/differentiation factor 9 [KO:K22673]
137004117  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
137004141  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
137004333  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
137004468  il12a; interleukin-12 subunit alpha [KO:K05406]
137004707  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
137004957  tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
137005067  il4; interleukin-4 [KO:K05430]
137005484  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
137006346  bmp2a; bone morphogenetic protein 2 [KO:K21283]
137006351  bmp4; bone morphogenetic protein 4 [KO:K04662]
137006470  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
137006885  gdf7; growth/differentiation factor 6-A [KO:K20013]
137006926  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
137006972  gdf3; protein DVR-1 isoform X1 [KO:K22672]
137007050  il17a/f1; interleukin 17a/f1 [KO:K05494]
137007180  tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
137007532  [KO:K21283]
137007596  ngfrb; nerve growth factor receptor b isoform X1 [KO:K02583]
137007626  gdf2; growth/differentiation factor 2 [KO:K05503]
137007820  [KO:K05150]
137008089  gdf10b; growth/differentiation factor 10b [KO:K22674]
137008185  ndr2; nodal-related 2 [KO:K04666]
137008297  bmpr1ab; bone morphogenetic protein receptor, type IAb isoform X1 [KO:K04673] [EC:2.7.11.30]
137008802  [KO:K04193]
137008857  [KO:K05072]
137008905  bmp7b; bone morphogenetic protein 7b isoform X1 [KO:K16621]
137008959  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a isoform X1 [KO:K05146]
137009089  acvr1ba; activin A receptor type 1Ba [KO:K13567] [EC:2.7.11.30]
137009180  [KO:K04193]
137009397  epor; erythropoietin receptor [KO:K05079]
137009461  cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
137009550  [KO:K04193]
137009571  ngfa; neurotrophin-7 [KO:K02582]
137009589  [KO:K04193]
137009702  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
137010665  ifnphi1; interferon phi 1 isoform X1 [KO:K05414]
137010678  ifnphi3; interferon phi 3 [KO:K05414]
137010691  gh1; somatotropin [KO:K05438]
137010759  lepr; leptin receptor isoform X1 [KO:K05062]
137010811  acvr2ab; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
137010814  ackr3b; atypical chemokine receptor 3b [KO:K04304]
137010928  mpl; thrombopoietin receptor isoform X1 [KO:K05082]
137010948  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
137010979  tnfrsf18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
137010998  [KO:K22687]
137011183  bmpr2a; bone morphogenetic protein receptor type-2a isoform X1 [KO:K04671] [EC:2.7.11.30]
137011266  ccr7; C-C chemokine receptor type 7 [KO:K04182]
137011306  gdf5; growth/differentiation factor 5 [KO:K04664]
137011506  ngfb; nerve growth factor [KO:K02582]
137011603  inha; inhibin alpha chain [KO:K05500]
137011621  acvr1bb; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
137011723  il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
137012508  lifrb; LIF receptor subunit alpha b isoform X1 [KO:K05058]
137012525  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
137012714  csf1rb; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
137012945  prlra; prolactin receptor a [KO:K05081]
137013083  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
137013180  ndr1; nodal-related 1 [KO:K04666]
137013434  ackr4b; atypical chemokine receptor 4b isoform X1 [KO:K04186]
137013477  bmp6; bone morphogenetic protein 6 [KO:K16620]
137013578  inhbaa; inhibin subunit beta Aa [KO:K04667]
137013795  [KO:K14625]
137013796  [KO:K14625]
137013880  ccr9b; C-C chemokine receptor type 9 isoform X1 [KO:K04184]
137013992  il12ba; interleukin 12Ba [KO:K05425]
137014005  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
137014020  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
137014339  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
137014441  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
137014803  [KO:K22629]
137015217  [KO:K16595]
137015360  [KO:K16595]
137015510  [KO:K12499]
137017142  [KO:K05153]
137017366  il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
137017378  csf2rb; cytokine receptor common subunit beta isoform X1 [KO:K04738]
137017609  [KO:K05490]
137017809  [KO:K05071]
137017812  [KO:K05071]
137017818  il21r.1; interleukin 21 receptor, tandem duplicate 1 [KO:K05075]
137017875  rell2; RELT-like protein 2 [KO:K26541]
137018015  clcf1; uncharacterized protein clcf1 [KO:K05421]
137018511  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
137018560  bmp2b; bone morphogenetic protein 2b [KO:K21283]
137018681  il21; interleukin-21 isoform X1 [KO:K05434]
137018693  [KO:K05433]
137018740  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
137019020  ccr6a; C-C chemokine receptor type 6a [KO:K04181]
137019086  il17a/f3; interleukin 17a/f3 [KO:K05494]
137019096  tnfrsf21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157]
137019459  il20ra; interleukin-20 receptor subunit alpha [KO:K05136]
137020113  gdf10a; growth/differentiation factor 10 [KO:K22674]
137020200  bmp5; bone morphogenetic protein 5 [KO:K04663]
137020504  bmpr1aa; bone morphogenetic protein receptor, type IAa isoform X1 [KO:K04673] [EC:2.7.11.30]
137020602  il2rgb; interleukin 2 receptor, gamma b [KO:K05070]
137020633  [KO:K05416]
137020634  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) [KO:K10031]
137020779  cd40lg; CD40 ligand isoform X1 [KO:K03161]
137020795  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
137020917  [KO:K22687]
137020962  tnfrsf9b; tumor necrosis factor receptor superfamily member 9b isoform X1 [KO:K05146]
137021099  csf1a; macrophage colony-stimulating factor 1a [KO:K05453]
137021108  il10; interleukin-10 [KO:K05443]
137021109  [KO:K22667]
137021111  [KO:K22667]
137021152  il12rb1; leukemia inhibitory factor receptor isoform X1 [KO:K05063]
137021161  gdf11; growth/differentiation factor 11 [KO:K22679]
137021183  bmp7a; bone morphogenetic protein 7a isoform X1 [KO:K16621]
137021197  ccl25b; C-C motif chemokine 25b [KO:K13072]
137021212  [KO:K13072]
137021395  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
137021417  il17rc; uncharacterized protein il17rc [KO:K05166]
137021502  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
137022535  bmp16; bone morphogenetic protein 16 [KO:K21283]
137022539  smtla; somatolactin alpha [KO:K05438]
137022573  [KO:K04190]
137022796  il17c; interleukin-17C [KO:K05491]
137023185  relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
137023249  lepa; leptin a [KO:K05424]
137023340  il34; interleukin-34 [KO:K22633]
137023882  ifng1; interferon gamma 1 [KO:K04687]
137023885  il22; interleukin-22 [KO:K05445]
137023893  prl2; prolactin 2 [KO:K05439]
137023942  lepb; leptin b [KO:K05424]
137024366  il17ra1a; interleukin 17 receptor A1a [KO:K05164]
137024566  [KO:K05148]
137024719  [KO:K04180]
137024772  [KO:K05152]
137025058  [KO:K05076]
137025285  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
137025900  cxcr3.3; C-X-C chemokine receptor type 3.3 [KO:K04188]
137025916  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
137026185  ccl27a; C-C motif chemokine 27a [KO:K05513]
137026477  gdf6a; growth/differentiation factor 6-A [KO:K20012]
137026698  [KO:K05165]
137026699  [KO:K05165]
137027021  [KO:K05152]
137027024  [KO:K05152]
137027025  [KO:K05152]
137027027  [KO:K05152]
137027063  ghra; growth hormone receptor a [KO:K05080]
137027402  [KO:K05168]
137027525  cntfr; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
137027660  mstna; myostatin a [KO:K05497]
137027750  amh; muellerian-inhibiting factor [KO:K04665]
137028272  [KO:K22670]
137028480  bmpr1bb; bone morphogenetic protein receptor, type IBb [KO:K13578] [EC:2.7.11.30]
137028514  ccl27b; C-C motif chemokine 27b [KO:K05513]
137028548  [KO:K04519]
137028679  [KO:K05070]
137028922  il11ra; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
137029206  [KO:K04188]
137029213  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) [KO:K10031]
137029421  [KO:K04519]
137029422  [KO:K04519]
137029423  [KO:K04519]
137029424  [KO:K04519]
137029701  epob; erythropoietin b [KO:K05437]
137029747  ccl19b; C-C motif chemokine 19b [KO:K05512]
137029801  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
137029882  cxcl8b.3; interleukin-8b.3 [KO:K10030]
137029902  il13ra1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
137029998  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
137030271  epoa; erythropoietin isoform X1 [KO:K05437]
137030378  bmp15; bone morphogenetic protein 15 [KO:K05498]
137030563  [KO:K04180]
137030654  cxcl19; C-X-C motif chemokine 19 [KO:K10030]
137030658  il16; pro-interleukin-16 isoform X1 [KO:K22628]
137031112  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
137031117  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
137031137  cd27; CD27 antigen isoform X1 [KO:K05144]
137031161  rell1; RELT-like protein 1 [KO:K26541]
137031864  il11a; interleukin-11 isoform X1 [KO:K05417]
137031929  [KO:K05477]
137032024  [KO:K06454]
137032086  [KO:K06454]
137032098  ifngr1; interferon gamma receptor 1 [KO:K05132]
137032102  cxcr3.1; C-X-C chemokine receptor type 3.1 isoform X1 [KO:K04188]
137032155  cxcl8a; interleukin-8 [KO:K10030]
137032192  [KO:K05080]
137032527  il15; interleukin-15 [KO:K05433]
137032696  il6r; interleukin-6 receptor subunit alpha [KO:K05055]
137032771  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
137033547  eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
137033605  bmpr1ba; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
137033625  [KO:K10032]
137033633  lifra; LIF receptor subunit alpha a isoform X1 [KO:K05058]
137033635  osmr; leukemia inhibitory factor receptor isoform X1 [KO:K05057]
137033802  [KO:K22629]
137033944  bmp10; bone morphogenetic protein 10 [KO:K22670]
137033975  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
137034002  eda; ectodysplasin-A isoform X1 [KO:K05480]
137034209  m17; IL-6 subfamily cytokine M17 [KO:K05420]
137034278  bmp3; bone morphogenetic protein 3 [KO:K05496]
137034297  tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
137034684  [KO:K12672]
137034702  il13ra2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
137034708  [KO:K12672]
137034718  [KO:K12672]
137034723  [KO:K12672]
137034724  [KO:K12672]
137034802  [KO:K12672]
137034836  [KO:K12672]
137034932  spaw; southpaw [KO:K04666]
137035000  [KO:K12672]
137035366  il1rl2; interleukin-1 receptor type 1 [KO:K04386]
137035371  [KO:K04675] [EC:2.7.11.30]
137035389  mstnb; growth/differentiation factor 8 [KO:K05497]
137035505  [KO:K05050]
137035506  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
137035519  crfb2; cytokine receptor family member b2 isoform X1 [KO:K05131]
137035530  crfb4; cytokine receptor family member b4 [KO:K05135]
137035657  ackr3a; atypical chemokine receptor 3a [KO:K04304]
137035711  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
137035754  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
137035779  [KO:K13568] [EC:2.7.11.30]
137035793  inhbb; inhibin beta B chain isoform X1 [KO:K22687]
137035818  il17d; interleukin-17D [KO:K05492]
137035846  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
137035948  il1rl1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
137036012  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
137036064  bmpr2b; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
137036287  [KO:K04386]
137036386  [KO:K05135]
137036388  [KO:K05135]
137036420  [KO:K05171]
137036515  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
137037220  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
137037746  gdf6b; growth/differentiation factor 6-B isoform X1 [KO:K20012]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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