KEGG   PATHWAY: ecb04150
Entry
ecb04150                    Pathway                                
Name
mTOR signaling pathway - Equus caballus (horse)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04150  mTOR signaling pathway
ecb04150

Organism
Equus caballus (horse) [GN:ecb]
Gene
100070633  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
100064046  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
100051821  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
100061223  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100055525  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100050282  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
100057005  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X5 [KO:K02148]
100056307  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
111767396  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
100052659  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
100053341  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100049854  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102148469  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100051640  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
100064677  V-type proton ATPase subunit G 3-like [KO:K02152]
100051132  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102150189  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
100054947  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100052779  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
100063939  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
100629409  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
111776190  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
106783217  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
100052790  FLCN; folliculin [KO:K09594]
100072917  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
100069124  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
100063565  RRAGA; ras-related GTP-binding protein A [KO:K16185]
100629499  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
100068917  RRAGC; ras-related GTP-binding protein C [KO:K16186]
100071018  RRAGD; ras-related GTP-binding protein D [KO:K16186]
100056552  SESN2; sestrin-2 [KO:K20394]
100146562  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X2 [KO:K23080]
100063037  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
100052380  MIOS; GATOR complex protein MIOS [KO:K20407]
100630847  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
100065239  WDR24; GATOR complex protein WDR24 [KO:K20408]
100055157  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
100057913  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
100058243  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
100061750  NPRL2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
100066396  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
100053697  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
100050623  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
100056244  RPTOR; regulatory-associated protein of mTOR isoform X10 [KO:K07204]
100052282  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100057185  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
100146703  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100067764  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
100055499  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
100058794  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
100052610  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
100072273  LPIN1; phosphatidate phosphatase LPIN1 isoform X5 [KO:K15728] [EC:3.1.3.4]
100055753  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
100051300  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
100073154  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
100057875  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100057254  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100066216  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
100068758  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X2 [KO:K03259]
100053005  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100057481  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100061920  EIF4B; eukaryotic translation initiation factor 4B isoform X3 [KO:K03258]
100052368  RPS6; 40S ribosomal protein S6 [KO:K02991]
100064638  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
100066574  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
100055913  STK11; serine/threonine-protein kinase STK11 isoform X3 [KO:K07298] [EC:2.7.11.1]
100063745  CAB39; calcium-binding protein 39 [KO:K08272]
100050219  CAB39L; calcium-binding protein 39-like [KO:K08272]
100034159  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100009710  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100066615  TSC1; hamartin isoform X1 [KO:K07206]
100065679  TSC2; tuberin isoform X2 [KO:K07207]
100051625  TBC1D7; TBC1 domain family member 7 [KO:K20396]
100064440  RHEB; GTP-binding protein Rheb [KO:K07208]
100072811  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100058859  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100063931  WNT2B; protein Wnt-2b [KO:K00182]
100056092  WNT2; protein Wnt-2 precursor [KO:K00182]
100049880  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100061145  WNT3A; protein Wnt-3a [KO:K00312]
100071678  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
100056017  WNT5B; protein Wnt-5b [KO:K00444]
100059157  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
100058824  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
100053027  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
100055450  WNT7A; protein Wnt-7a [KO:K00572]
111768287  protein Wnt-7a [KO:K00572]
100070360  WNT8B; protein Wnt-8b [KO:K00714]
100072609  WNT8A; protein Wnt-8a isoform X3 [KO:K00714]
100061110  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
100063730  WNT9B; protein Wnt-9b [KO:K01064]
100051649  WNT10B; protein Wnt-10b [KO:K01357]
111773843  WNT10A; protein Wnt-10a [KO:K01357]
100064184  WNT11; protein Wnt-11 [KO:K01384]
100071393  WNT16; protein Wnt-16 [KO:K01558]
102147960  FZD7; frizzled-7 [KO:K02432]
106783041  FZD1; frizzled-1 [KO:K02432]
100050809  FZD2; frizzled-2 [KO:K02235]
100054732  FZD3; frizzled-3 [KO:K02329]
100050465  FZD4; frizzled-4 [KO:K02354]
100146215  FZD5; frizzled-5 [KO:K02375]
111771171  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100056351  FZD6; frizzled-6 [KO:K02376]
100062909  FZD10; frizzled-10 [KO:K02842]
100061635  FZD9; frizzled-9 [KO:K02842]
100063409  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
100147353  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
100061612  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100147200  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
100147654  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100033834  TNF; tumor necrosis factor [KO:K03156]
100059548  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111776000  INS; insulin [KO:K04526]
100034198  IGF1; insulin-like growth factor I precursor [KO:K05459]
100066248  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100051785  LOW QUALITY PROTEIN: GTPase KRas-like [KO:K07827]
100059469  NRAS; GTPase NRas [KO:K07828]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100058911  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100057166  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100050176  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100072397  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
100061987  IRS1; insulin receptor substrate 1 [KO:K16172]
100052122  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100062388  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100630736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100067215  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X3 [KO:K20410]
100066797  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
100051354  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
100052234  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100069215  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100062549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100073151  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ecb00561  Glycerolipid metabolism
ecb04010  MAPK signaling pathway
ecb04140  Autophagy - animal
ecb04151  PI3K-Akt signaling pathway
ecb04152  AMPK signaling pathway
ecb04810  Regulation of actin cytoskeleton
ecb04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system