KEGG   PATHWAY: ecb04151
Entry
ecb04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Equus caballus (horse)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ecb04151  PI3K-Akt signaling pathway
ecb04151

Other DBs
GO: 0043491
Organism
Equus caballus (horse) [GN:ecb]
Gene
100009689  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
100009697  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100009701  TLR2; toll-like receptor 2 precursor [KO:K10159]
100009704  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100009710  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100009713  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
100033837  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100033839  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
100033849  EPO; erythropoietin precursor [KO:K05437]
100033877  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100033911  COMP; cartilage oligomeric matrix protein precursor [KO:K04659]
100033922  CSF3; granulocyte colony-stimulating factor isoform 2 [KO:K05423]
100033933  HSP90B1; endoplasmin precursor [KO:K09487]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100033956  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100033957  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
100033959  KDR; vascular endothelial growth factor receptor 2 isoform X2 [KO:K05098] [EC:2.7.10.1]
100033960  FGF1; fibroblast growth factor 1 [KO:K18496]
100033961  FGF7; fibroblast growth factor 7 [KO:K04358]
100034034  PRL; prolactin precursor [KO:K05439]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100034127  KITLG; kit ligand precursor [KO:K05461]
100034150  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
100034159  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100034169  IL7R; interleukin-7 receptor subunit alpha precursor [KO:K05072]
100034180  GH1; somatotropin precursor [KO:K05438]
100034182  IGF2; insulin-like growth factor II precursor [KO:K13769]
100034189  FN1; fibronectin isoform X1 [KO:K05717]
100034196  IL6; interleukin-6 precursor [KO:K05405]
100034198  IGF1; insulin-like growth factor I precursor [KO:K05459]
100034204  IL2; interleukin-2 precursor [KO:K05429]
100034225  IL4; interleukin-4 precursor [KO:K05430]
100037402  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100049816  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14 [KO:K05631]
100049835  TNC; tenascin isoform X1 [KO:K06252]
100049848  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
100050035  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100050037  FGF20; fibroblast growth factor 20 [KO:K04358]
100050044  THBS2; thrombospondin-2 precursor [KO:K04659]
100050167  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
100050182  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X6 [KO:K05085] [EC:2.7.10.1]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100050353  FGF9; fibroblast growth factor 9 [KO:K04358]
100050528  AREG; amphiregulin [KO:K09782]
100050532  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
100050735  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
100050877  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
100050934  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
100051005  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100051150  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100051221  FGF6; fibroblast growth factor 6 [KO:K04358]
100051266  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100051341  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
100051349  PGF; placenta growth factor isoform X1 [KO:K16859]
100051430  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
100051487  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100051499  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051679  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100051715  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100051737  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100051785  [KO:K07827]
100051790  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100051839  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
100051866  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100051890  ANGPT2; angiopoietin-2 isoform X2 [KO:K05466]
100051948  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
100051990  BRCA1; breast cancer type 1 susceptibility protein isoform X4 [KO:K10605] [EC:2.3.2.27]
100052030  [KO:K13304] [EC:2.7.11.1]
100052084  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100052122  [KO:K02649]
100052233  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
100052266  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
100052326  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100052368  RPS6; 40S ribosomal protein S6 [KO:K02991]
100052489  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100052545  IFNB1; interferon beta precursor [KO:K05415]
100052560  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X2 [KO:K07825]
100052655  FGF10; fibroblast growth factor 10 [KO:K04358]
100052658  [KO:K05415]
100052775  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
100052818  IFN-ALPHA2; interferon alpha-2 precursor [KO:K05414]
100052921  [KO:K05414]
100052979  IBSP; bone sialoprotein 2 [KO:K06253]
100053005  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100053020  GHR; growth hormone receptor isoform X2 [KO:K05080]
100053022  IFNA1; interferon alpha-1 precursor [KO:K05414]
100053029  SPP1; osteopontin [KO:K06250]
100053110  [KO:K05414]
100053210  [KO:K05414]
100053302  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
100053304  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100053462  ITGB8; integrin beta-8 [KO:K06591]
100053539  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
100053597  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100053644  EPHA2; ephrin type-A receptor 2 isoform X3 [KO:K05103] [EC:2.7.10.1]
100053793  PRLR; prolactin receptor [KO:K05081]
100053797  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100053882  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100054008  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100054331  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100054374  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100054440  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
100054529  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
100054542  FGF21; fibroblast growth factor 21 [KO:K22429]
100054545  COL4A5; collagen alpha-5(IV) chain isoform X5 [KO:K06237]
100054723  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100054739  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
100054765  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
100054803  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100054859  NTF4; neurotrophin-4 [KO:K12457]
100054880  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
100054903  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2 [KO:K01596] [EC:4.1.1.32]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100054977  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6 [KO:K11584]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100055173  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
100055238  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100055269  LAMC1; laminin subunit gamma-1 [KO:K05635]
100055302  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
100055332  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100055447  BAD; bcl2-associated agonist of cell death [KO:K02158]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100055522  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
100055681  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
100055698  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100055710  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100055911  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
100055913  STK11; serine/threonine-protein kinase STK11 isoform X3 [KO:K07298] [EC:2.7.11.1]
100056013  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100056060  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100056084  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
100056202  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100056217  ITGA8; integrin alpha-8 [KO:K06584]
100056244  RPTOR; regulatory-associated protein of mTOR isoform X10 [KO:K07204]
100056444  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
100056482  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
100056564  LAMB3; laminin subunit beta-3 [KO:K06244]
100056571  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
100056605  EREG; proepiregulin [KO:K09784]
100056814  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
100057002  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100057022  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100057123  YWHAQ; 14-3-3 protein theta [KO:K16197]
100057142  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
100057186  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
100057208  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100057254  EIF4E2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100057478  THBS1; thrombospondin-1 precursor [KO:K16857]
100057481  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
100057483  RELA; transcription factor p65 [KO:K04735]
100057614  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100057766  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
100057875  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100058057  LAMA5; laminin subunit alpha-5 [KO:K06240]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100058274  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
100058432  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100058460  FGF23; fibroblast growth factor 23 [KO:K22428]
100058605  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100058621  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
100058660  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100058756  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100059034  VTN; vitronectin [KO:K06251]
100059131  IL7; interleukin-7 isoform X3 [KO:K05431]
100059216  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100059315  TNXB; tenascin-X isoform X7 [KO:K06252]
100059348  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
100059469  NRAS; GTPase NRas [KO:K07828]
100059472  VWF; von Willebrand factor precursor [KO:K03900]
100059731  YWHAG; 14-3-3 protein gamma [KO:K16198]
100059736  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100059860  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
100059955  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
100059962  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
100060079  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
100060112  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100060219  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100060309  FGF8; fibroblast growth factor 8 [KO:K04358]
100060360  LAMB1; laminin subunit beta-1 [KO:K05636]
100060422  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
100060423  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
100060431  RBL2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
100060434  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100060488  FGF19; fibroblast growth factor 19 [KO:K22603]
100060525  FGF4; fibroblast growth factor 4 [KO:K04358]
100060890  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
100060957  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X5 [KO:K04354]
100061033  GSK3B; glycogen synthase kinase-3 beta isoform X6 [KO:K03083] [EC:2.7.11.26]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061353  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
100061395  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
100061488  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100061556  TNN; tenascin-N isoform X3 [KO:K06252]
100061625  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100061691  TNR; tenascin-R isoform X1 [KO:K06252]
100061700  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100061780  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
100061920  EIF4B; eukaryotic translation initiation factor 4B isoform X3 [KO:K03258]
100061987  IRS1; insulin receptor substrate 1 [KO:K16172]
100062015  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100062044  TP53; cellular tumor antigen p53 [KO:K04451]
100062160  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100062224  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
100062307  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100062315  MTCP1; protein p13 MTCP-1 [KO:K16837]
100062388  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100062627  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
100062750  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
100062779  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
100062810  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
100062878  YWHAH; 14-3-3 protein eta [KO:K16198]
100063153  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100063240  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
100063307  EFNA1; ephrin-A1 [KO:K05462]
100063318  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100063339  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100063367  ITGA2; integrin alpha-2 [KO:K06481]
100063383  SYK; tyrosine-protein kinase SYK isoform X3 [KO:K05855] [EC:2.7.10.2]
100063402  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100063434  ITGA1; integrin alpha-1 precursor [KO:K06480]
100063449  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
100063518  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100063747  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
100063795  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
100064022  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100064031  OSM; oncostatin-M [KO:K05418]
100064056  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100064117  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100064145  [KO:K06238]
100064173  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
100064264  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100064285  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
100064312  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
100064440  RHEB; GTP-binding protein Rheb [KO:K07208]
100064468  [KO:K05414]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100064551  [KO:K05414]
100064594  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
100064612  [KO:K05414]
100064655  ITGA5; integrin alpha-5 [KO:K06484]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100064731  IFND1; interferon delta 1 precursor [KO:K05414]
100064813  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
100064828  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100064862  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
100064906  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100064975  IFND2; interferon-delta 2 precursor [KO:K05414]
100065205  ITGA10; integrin alpha-10 isoform X4 [KO:K06586]
100065211  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100065327  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
100065517  PSPN; persephin [KO:K25416]
100065669  NGF; beta-nerve growth factor [KO:K02582]
100065679  TSC2; tuberin isoform X2 [KO:K07207]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100066148  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100066216  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
100066248  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100066264  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100066356  COL6A3; collagen alpha-3(VI) chain isoform X3 [KO:K06238]
100066388  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
100066558  FOXO3; forkhead box protein O3 [KO:K09408]
100066590  CCND3; G1/S-specific cyclin-D3 isoform X3 [KO:K10152]
100066615  TSC1; hamartin isoform X1 [KO:K07206]
100066773  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100066819  OSMR; oncostatin-M-specific receptor subunit beta isoform X4 [KO:K05057]
100066875  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
100066882  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
100066890  TLR4; toll-like receptor 4 precursor [KO:K10160]
100066963  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
100067053  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
100067486  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100067794  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
100067818  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
100067886  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100067894  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580]
100068097  MYC; myc proto-oncogene protein [KO:K04377]
100068679  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100068758  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X2 [KO:K03259]
100069096  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
100069253  CSF3R; granulocyte colony-stimulating factor receptor isoform X5 [KO:K05061]
100069660  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
100069663  LAMC3; laminin subunit gamma-3 [KO:K06247]
100069676  IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
100069694  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100070133  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100070292  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
100070334  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100070376  ITGB5; integrin beta-5 [KO:K06588]
100070393  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100070408  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
100070683  [KO:K13303] [EC:2.7.11.1]
100070796  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100071749  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100071790  FGF16; fibroblast growth factor 16 [KO:K04358]
100072461  FGF22; fibroblast growth factor 22 [KO:K04358]
100072811  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100073067  LAMA2; laminin subunit alpha-2 isoform X3 [KO:K05637]
100073151  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
100073162  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
100073202  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
100073261  THBS4; thrombospondin-4 [KO:K04659]
100073278  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100146493  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
100146498  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
100146643  [KO:K06856]
100146649  FGF3; fibroblast growth factor 3 [KO:K04358]
100146703  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
100146791  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100147174  [KO:K05415]
100147451  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
100147468  CD19; B-lymphocyte antigen CD19 precursor [KO:K06465]
100147585  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100147607  CHAD; chondroadherin [KO:K06248]
100629648  FGF18; fibroblast growth factor 18 [KO:K04358]
100629781  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
100629885  [KO:K05414]
100629951  [KO:K05414]
100630002  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
100630067  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100630493  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
100630574  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100630736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102147510  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102148787  IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055]
102148973  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
102149114  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
106781070  [KO:K04737]
106782014  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
106782773  ARTN; artemin [KO:K25415]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
111769795  [KO:K05072]
111769802  [KO:K05072]
111771935  [KO:K10160]
111773925  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
111774192  NRTN; neurturin [KO:K25414]
111774429  EFNA2; ephrin-A2 [KO:K05462]
111776000  INS; insulin [KO:K04526]
791238  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
791241  COL2A1; collagen alpha-1(II) chain precursor [KO:K19719]
791245  LAMC2; laminin subunit gamma-2 precursor [KO:K06246]
791252  IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ecb00010  Glycolysis / Gluconeogenesis
ecb04010  MAPK signaling pathway
ecb04012  ErbB signaling pathway
ecb04062  Chemokine signaling pathway
ecb04064  NF-kappa B signaling pathway
ecb04068  FoxO signaling pathway
ecb04110  Cell cycle
ecb04115  p53 signaling pathway
ecb04150  mTOR signaling pathway
ecb04210  Apoptosis
ecb04370  VEGF signaling pathway
ecb04510  Focal adhesion
ecb04620  Toll-like receptor signaling pathway
ecb04630  JAK-STAT signaling pathway
ecb04662  B cell receptor signaling pathway
ecb04910  Insulin signaling pathway
KO pathway
ko04151   

DBGET integrated database retrieval system