KEGG   PATHWAY: ecb04810
Entry
ecb04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Equus caballus (horse)
Class
Cellular Processes; Cell motility
Pathway map
ecb04810  Regulation of actin cytoskeleton
ecb04810

Other DBs
GO: 0030036
Organism
Equus caballus (horse) [GN:ecb]
Gene
100009697  ITGA2B; integrin alpha-IIb precursor [KO:K06476]
100009709  ITGB3; integrin beta-3 precursor [KO:K06493]
100033878  ACTB; actin, cytoplasmic 1 [KO:K05692]
100033909  ACTR3; actin-related protein 3 [KO:K18584]
100033955  FGF2; fibroblast growth factor 2 [KO:K18497]
100033956  FGFR2; fibroblast growth factor receptor 2 precursor [KO:K05093] [EC:2.7.10.1]
100033960  FGF1; fibroblast growth factor 1 [KO:K18496]
100033961  FGF7; fibroblast growth factor 7 [KO:K04358]
100034015  TMSB4X; thymosin beta-4 [KO:K05764]
100034056  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
100034114  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100034183  C9; complement component C9 precursor [KO:K04000]
100034186  GSN; gelsolin [KO:K05768]
100034189  FN1; fibronectin isoform X1 [KO:K05717]
100049872  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
100050037  FGF20; fibroblast growth factor 20 [KO:K04358]
100050092  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100050139  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100050207  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
100050227  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100050346  MYH11; myosin-11 isoform X1 [KO:K10352]
100050353  FGF9; fibroblast growth factor 9 [KO:K04358]
100050494  CFL2; cofilin-2 isoform X2 [KO:K05765]
100050520  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100050855  CRKL; crk-like protein [KO:K04438]
100050974  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100051110  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100051221  FGF6; fibroblast growth factor 6 [KO:K04358]
100051266  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100051370  [KO:K12757]
100051415  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100051591  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
100051623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100051679  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
100051753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100051785  [KO:K07827]
100051814  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
100051848  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100052122  [KO:K02649]
100052612  SCIN; adseverin [KO:K05768]
100052655  FGF10; fibroblast growth factor 10 [KO:K04358]
100052764  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100053070  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100053343  RHOA; transforming protein RhoA [KO:K04513]
100053462  ITGB8; integrin beta-8 [KO:K06591]
100053518  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
100053698  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100053797  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
100053811  PXN; paxillin isoform X1 [KO:K05760]
100053889  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100054315  PAK3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
100054374  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
100054482  MYH9; myosin-9 [KO:K10352]
100054542  FGF21; fibroblast growth factor 21 [KO:K22429]
100054699  BDKRB1; B1 bradykinin receptor [KO:K03915]
100054701  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100054738  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100054796  BDKRB2; B2 bradykinin receptor [KO:K03916]
100054961  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100055024  ITGB1; integrin beta-1 precursor [KO:K05719]
100055086  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100055199  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100055236  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
100055481  HRAS; GTPase HRas isoform X1 [KO:K02833]
100055697  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
100055781  RRAS; ras-related protein R-Ras [KO:K07829]
100056049  [KO:K06464]
100056128  ITGB2; integrin beta-2 [KO:K06464]
100056145  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
100056163  PFN4; profilin-4 isoform X1 [KO:K05759]
100056202  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
100056217  ITGA8; integrin alpha-8 [KO:K06584]
100056444  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
100056559  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
100056622  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
100056633  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100056724  FAM49A; protein FAM49A isoform X1 [KO:K27976]
100057058  DIAPH2; protein diaphanous homolog 2 isoform X3 [KO:K05741]
100057358  ENAH; protein enabled homolog isoform X7 [KO:K05746]
100057521  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100057603  CFL1; cofilin-1 [KO:K05765]
100057614  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100057701  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100057737  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
100057856  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100058141  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100058160  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100058184  BRK1; protein BRICK1 [KO:K05752]
100058188  CDC42; cell division control protein 42 homolog [KO:K04393]
100058228  SPATA13; spermatogenesis-associated protein 13 isoform X5 [KO:K05769]
100058245  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
100058246  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
100058331  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100058336  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100058358  [KO:K05755]
100058419  LIMK2; LIM domain kinase 2 isoform X3 [KO:K05744] [EC:2.7.11.1]
100058460  FGF23; fibroblast growth factor 23 [KO:K22428]
100058756  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100059077  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100059233  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100059256  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100059292  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
100059423  C8B; complement component C8 beta chain [KO:K03998]
100059461  C8A; complement component C8 alpha chain [KO:K03997]
100059467  EZR; ezrin [KO:K08007]
100059469  NRAS; GTPase NRas [KO:K07828]
100059655  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
100059815  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100060005  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100060183  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100060219  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
100060309  FGF8; fibroblast growth factor 8 [KO:K04358]
100060444  MYL10; myosin regulatory light chain 10 [KO:K12756]
100060488  FGF19; fibroblast growth factor 19 [KO:K22603]
100060501  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100060525  FGF4; fibroblast growth factor 4 [KO:K04358]
100061031  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
100061130  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100061212  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
100061295  PFN1; profilin-1 [KO:K05759]
100061488  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
100061732  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100061858  RDX; radixin isoform X3 [KO:K05762]
100062015  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
100062071  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
100062100  LIMK1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
100062440  [KO:K12757]
100062541  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
100062708  MYH10; myosin-10 isoform X1 [KO:K10352]
100062972  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100063005  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
100063100  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
100063190  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100063217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100063367  ITGA2; integrin alpha-2 [KO:K06481]
100063434  ITGA1; integrin alpha-1 precursor [KO:K06480]
100063518  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
100063747  ITGB7; integrin beta-7 isoform X2 [KO:K06590]
100063928  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X15 [KO:K12329]
100064056  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100064117  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100064165  VCL; vinculin isoform X1 [KO:K05700]
100064268  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
100064431  APC; adenomatous polyposis coli protein [KO:K02085]
100064473  KRAS; GTPase KRas isoform X1 [KO:K07827]
100064655  ITGA5; integrin alpha-5 [KO:K06484]
100064671  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100064753  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
100064779  ITGAX; integrin alpha-X precursor [KO:K06462]
100064781  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100064803  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
100064906  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100065012  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
100065073  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100065205  ITGA10; integrin alpha-10 isoform X4 [KO:K06586]
100065211  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100065348  MSN; moesin [KO:K05763]
100065508  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
100065683  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100065760  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100065944  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100065952  C6; complement component C6 [KO:K03995]
100065996  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100066010  VAV1; proto-oncogene vav [KO:K05730]
100066126  C7; complement component C7 isoform X3 [KO:K03996]
100066173  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100066282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100066343  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100066445  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100066489  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
100066733  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
100066751  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
100067000  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100067289  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100067370  [KO:K05769]
100067655  C5; complement C5 [KO:K03994]
100067755  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100067886  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
100067929  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100068133  KNG1; kininogen-1 isoform X2 [KO:K03898]
100068260  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
100068561  FAM49B; protein FAM49B isoform X1 [KO:K27976]
100068679  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
100068706  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100068724  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
100068908  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
100069175  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100069870  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
100070283  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
100070376  ITGB5; integrin beta-5 [KO:K06588]
100070482  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100070959  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100071067  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100071224  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
100071463  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100071503  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
100071546  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
100071586  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100071665  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
100071749  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100071790  FGF16; fibroblast growth factor 16 [KO:K04358]
100072180  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100072186  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
100072339  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
100072356  CRK; adapter molecule crk isoform X1 [KO:K04438]
100072461  FGF22; fibroblast growth factor 22 [KO:K04358]
100072673  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
100073278  F2R; proteinase-activated receptor 1 isoform X2 [KO:K03914]
100073279  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
100146348  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100146649  FGF3; fibroblast growth factor 3 [KO:K04358]
100146754  PFN3; profilin-3 [KO:K05759]
100146940  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
100147102  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
100147492  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
100147585  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100147688  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100629648  FGF18; fibroblast growth factor 18 [KO:K04358]
100630364  PFN2; profilin-2 isoform X1 [KO:K05759]
100630525  MYH14; myosin-14 isoform X1 [KO:K10352]
100630574  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102147510  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102147631  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
102148861  [KO:K05759]
102150569  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
106782874  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
111768803  ABI2; abl interactor 2 isoform X1 [KO:K05751]
111768857  [KO:K05769]
111768858  [KO:K05769]
111770701  [KO:K23612]
111771616  [KO:K12757]
111771929  [KO:K05769]
111774175  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111776000  INS; insulin [KO:K04526]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ecb04010  MAPK signaling pathway
ecb04510  Focal adhesion
ecb04520  Adherens junction
KO pathway
ko04810   

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