KEGG   PATHWAY: fca05213
Entry
fca05213                    Pathway                                
Name
Endometrial cancer - Felis catus (domestic cat)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
fca05213  Endometrial cancer
fca05213

Disease
H00026  Endometrial cancer
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081548  FOXO3; forkhead box protein O3 [KO:K09408]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101086346  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
101086509  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087971  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101088077  LEF1; lymphoid enhancer-binding factor 1 isoform X3 [KO:K04492]
101088568  CTNNA2; catenin alpha-2 isoform X1 [KO:K05691]
101088804  AXIN1; LOW QUALITY PROTEIN: axin-1 [KO:K02157]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101089037  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
101089324  CTNNA1; catenin alpha-1 [KO:K05691]
101089839  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101089850  TCF7L1; transcription factor 7-like 1 isoform X3 [KO:K04490]
101091813  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101092211  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101092790  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101093061  AXIN2; axin-2 isoform X1 [KO:K04385]
101093286  [KO:K02649]
101093435  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101095156  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
101095391  CDH1; cadherin-1 [KO:K05689]
101095618  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096138  APC; adenomatous polyposis coli protein isoform X4 [KO:K02085]
101097211  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
101097342  CTNNB1; catenin beta-1 [KO:K02105]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101098768  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101099613  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101101686  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
493837  BAX; apoptosis regulator BAX [KO:K02159]
493847  TP53; cellular tumor antigen p53 [KO:K04451]
493943  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15947972
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
PMID:14747944
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
PMID:16508724
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
PMID:17028294
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
PMID:11431710
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
PMID:15284264
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
fca04010  MAPK signaling pathway
fca04012  ErbB signaling pathway
fca04060  Cytokine-cytokine receptor interaction
fca04110  Cell cycle
fca04115  p53 signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04310  Wnt signaling pathway
fca04520  Adherens junction
KO pathway
ko05213   

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