KEGG   PATHWAY: fca04151
Entry
fca04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Felis catus (domestic cat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
fca04151  PI3K-Akt signaling pathway
fca04151

Other DBs
GO: 0043491
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100037407  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100037415  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100125860  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100127108  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100127113  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
100135772  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100136904  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
100141386  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100144611  NGF; beta-nerve growth factor [KO:K02582]
100271864  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101080345  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X3 [KO:K16340] [EC:3.1.3.16]
101080351  [KO:K02991]
101080367  LAMB1; laminin subunit beta-1 [KO:K05636]
101080377  EIF4E; eukaryotic translation initiation factor 4E isoform X2 [KO:K03259]
101080415  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
101080595  FGF21; fibroblast growth factor 21 [KO:K22429]
101081041  AREG; amphiregulin isoform X1 [KO:K09782]
101081075  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101081140  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
101081156  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101081164  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X4 [KO:K11584]
101081323  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
101081364  EPOR; erythropoietin receptor isoform X2 [KO:K05079]
101081371  [KO:K05414]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081548  FOXO3; forkhead box protein O3 [KO:K09408]
101081603  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101081653  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
101081660  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101081745  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
101081746  FN1; fibronectin isoform X1 [KO:K05717]
101081776  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
101081809  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101081817  EIF4B; eukaryotic translation initiation factor 4B isoform X3 [KO:K03258]
101081928  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 isoform X1 [KO:K04541]
101081937  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
101082047  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
101082094  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101082104  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101082206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101082249  HSP90B1; endoplasmin [KO:K09487]
101082354  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101082969  TSC2; tuberin isoform X1 [KO:K07207]
101083160  RHEB; GTP-binding protein Rheb [KO:K07208]
101083266  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101083299  LAMA1; laminin subunit alpha-1 isoform X3 [KO:K05637]
101083363  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X3 [KO:K11583]
101083629  TNC; tenascin isoform X2 [KO:K06252]
101083726  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101083734  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
101083745  FGF22; fibroblast growth factor 22 [KO:K04358]
101083766  FGF20; fibroblast growth factor 20 [KO:K04358]
101083923  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
101084083  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101084114  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101084156  YWHAG; 14-3-3 protein gamma [KO:K16198]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101084335  FGF9; fibroblast growth factor 9 [KO:K04358]
101084346  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101084377  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101084597  IL7; interleukin-7 isoform X1 [KO:K05431]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101084615  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
101084652  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101084778  FGF16; fibroblast growth factor 16 [KO:K04358]
101084784  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X7 [KO:K09047]
101084799  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101084812  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
101084984  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101085024  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
101085293  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101085347  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
101085368  VEGFC; vascular endothelial growth factor C [KO:K05449]
101085388  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
101085481  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101085486  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
101085689  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101085703  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
101085757  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101085820  ITGAV; integrin alpha-V [KO:K06487]
101085951  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101085955  PSPN; persephin [KO:K25416]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101086093  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
101086148  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101086192  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086526  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101086580  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101086862  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
101086887  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101086907  LAMA4; laminin subunit alpha-4 isoform X2 [KO:K06241]
101086927  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
101087013  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
101087097  CREB3L1; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101087099  FGF19; fibroblast growth factor 19 [KO:K22603]
101087130  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101087199  THBS4; thrombospondin-4 [KO:K04659]
101087257  IRS1; insulin receptor substrate 1 [KO:K16172]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
101087493  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
101087512  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087724  ITGB8; integrin beta-8 [KO:K06591]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087973  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101088140  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101088219  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101088292  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
101088440  [KO:K05414]
101088476  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101088481  YWHAQ; 14-3-3 protein theta [KO:K16197]
101088571  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101088641  LAMB3; laminin subunit beta-3 [KO:K06244]
101088742  PDGFC; platelet-derived growth factor C [KO:K05450]
101088820  COMP; cartilage oligomeric matrix protein [KO:K04659]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101088915  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101088959  JAK2; tyrosine-protein kinase JAK2 isoform X3 [KO:K04447] [EC:2.7.10.2]
101089256  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101089378  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101089428  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101089498  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
101089571  LAMC2; laminin subunit gamma-2 [KO:K06246]
101089743  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
101089783  ITGA7; integrin alpha-7 isoform X4 [KO:K06583]
101089787  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101089838  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101090193  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
101090237  ITGA2; integrin alpha-2 [KO:K06481]
101090239  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101090285  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101090321  LAMC1; laminin subunit gamma-1 [KO:K05635]
101090419  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
101090489  FGF10; fibroblast growth factor 10 [KO:K04358]
101090606  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101090632  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101090796  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
101090817  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X2 [KO:K04544]
101090884  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101090950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101091156  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101091274  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
101091354  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7 [KO:K05629]
101091459  FGF6; fibroblast growth factor 6 [KO:K04358]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101091469  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
101091560  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101091685  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101091784  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X2 [KO:K04354]
101091812  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X3 [KO:K04688] [EC:2.7.11.1]
101091813  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101091855  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101091892  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101091977  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101092123  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
101092138  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101092159  ITGB3; integrin beta-3 [KO:K06493]
101092216  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101092339  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101092454  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101092465  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101092535  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
101092556  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101092561  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X2 [KO:K04688] [EC:2.7.11.1]
101092612  LAMA2; laminin subunit alpha-2 isoform X7 [KO:K05637]
101092622  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101092689  THBS1; thrombospondin-1 [KO:K16857]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101093002  COL4A5; collagen alpha-5(IV) chain isoform X4 [KO:K06237]
101093102  EREG; proepiregulin [KO:K09784]
101093156  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101093244  GHR; growth hormone receptor isoform X2 [KO:K05080]
101093255  MTCP1; protein p13 MTCP-1 [KO:K16837]
101093286  [KO:K02649]
101093317  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101093368  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101093524  ITGA11; integrin alpha-11 [KO:K06587]
101093555  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101093557  PKN3; serine/threonine-protein kinase N3 isoform X7 [KO:K23692]
101093580  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101093586  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101093644  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
101093801  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101093870  ITGA5; integrin alpha-5 [KO:K06484]
101093897  [KO:K16197]
101094264  SPP1; osteopontin isoform X1 [KO:K06250]
101094274  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101094363  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101094379  OSM; oncostatin-M isoform X2 [KO:K05418]
101094427  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2 [KO:K11584]
101094570  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
101094667  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101094727  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
101094822  EFNA3; ephrin-A3 [KO:K05462]
101094849  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X4 [KO:K09049]
101094857  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101094921  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101095077  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101095198  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101095252  IBSP; bone sialoprotein 2 [KO:K06253]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101095629  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
101095636  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
101095676  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101095733  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
101095825  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101095885  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X3 [KO:K07198] [EC:2.7.11.31]
101095904  PGF; placenta growth factor isoform X8 [KO:K16859]
101095952  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101096000  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101096030  COL4A1; collagen alpha-1(IV) chain isoform X2 [KO:K06237]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096163  [KO:K06238]
101096184  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101096215  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101096277  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101096282  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101096447  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101096463  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101096604  RELA; transcription factor p65 [KO:K04735]
101096629  TNR; tenascin-R [KO:K06252]
101097413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101097466  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [KO:K11583]
101097491  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101097547  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
101097770  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
101097858  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101097863  TNN; tenascin-N isoform X1 [KO:K06252]
101097871  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101097902  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101097903  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
101097982  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101097996  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
101097997  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
101098152  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
101098495  RPS6; 40S ribosomal protein S6 [KO:K02991]
101098499  LAMC3; laminin subunit gamma-3 [KO:K06247]
101098518  FGF18; fibroblast growth factor 18 [KO:K04358]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101098874  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
101098954  SGK1; serine/threonine-protein kinase Sgk1 isoform X4 [KO:K13302] [EC:2.7.11.1]
101099142  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101099264  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101099271  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101099546  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101099790  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101099908  YWHAH; 14-3-3 protein eta [KO:K16198]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101099982  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101100063  FGF23; fibroblast growth factor 23 [KO:K22428]
101100073  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
101100161  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101100222  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101100293  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101100428  NTF4; neurotrophin-4 [KO:K12457]
101100442  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X4 [KO:K09048]
101100567  THBS2; thrombospondin-2 [KO:K04659]
101100658  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101100682  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101100697  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101100765  VTN; vitronectin [KO:K06251]
101100861  F2R; LOW QUALITY PROTEIN: proteinase-activated receptor 1 [KO:K03914]
101100864  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
101100930  ITGA2B; integrin alpha-IIb [KO:K06476]
101100950  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101101086  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101101104  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
101101237  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101101247  ITGB5; integrin beta-5 [KO:K06588]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101311  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101101347  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101101425  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101101444  PRLR; prolactin receptor isoform X1 [KO:K05081]
101101514  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
101101519  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101101552  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
101101563  TNXB; tenascin-X isoform X1 [KO:K06252]
101101686  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
102899848  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102899974  [KO:K09554]
102900654  [KO:K06630]
102901787  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105261394  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
109493852  NRTN; neurturin [KO:K25414]
109501012  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
111556546  FGF4; fibroblast growth factor 4 [KO:K04358]
111556666  FGF3; fibroblast growth factor 3 [KO:K04358]
111557526  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111557556  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
111557596  [KO:K05414]
111557728  CHAD; chondroadherin [KO:K06248]
111559739  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111560806  [KO:K04736]
111561723  ARTN; artemin [KO:K25415]
111561761  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123380358  [KO:K04540]
123381775  [KO:K05414]
493648  IFNA8; interferon alpha-8 precursor [KO:K05414]
493653  IFNA7; interferon alpha precursor [KO:K05414]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
493687  IL6; interleukin-6 precursor [KO:K05405]
493690  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
493698  TLR4; toll-like receptor 4 precursor [KO:K10160]
493700  CSF3; granulocyte colony-stimulating factor precursor [KO:K05423]
493701  BCL2L1; bcl-2-like protein 1 [KO:K04570]
493703  VEGFD; vascular endothelial growth factor D [KO:K05449]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
493706  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
493760  VWF; von Willebrand factor precursor [KO:K03900]
493766  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
493796  FLT3LG; fms related tyrosine kinase 3 ligand precursor [KO:K05454]
493797  TLR2; toll-like receptor 2 [KO:K10159]
493801  EPO; erythropoietin precursor [KO:K05437]
493804  INS; insulin precursor [KO:K04526]
493840  IFNA5; interferon alpha-5 [KO:K05414]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
493847  TP53; cellular tumor antigen p53 [KO:K04451]
493849  IFNB1; interferon beta precursor [KO:K05415]
493931  GH1; somatotropin precursor [KO:K05438]
493934  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
493937  KITLG; kit ligand precursor [KO:K05461]
493939  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
493943  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493953  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
493958  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
493963  NTF3; neurotrophin-3 precursor [KO:K04356]
493970  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
723970  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
751114  IL2; interleukin-2 precursor [KO:K05429]
751514  IL4; interleukin-4 precursor [KO:K05430]
751517  PRL; prolactin precursor [KO:K05439]
751821  ITGB1; integrin beta-1 precursor [KO:K05719]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
768260  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
768269  BAD; bcl2-associated agonist of cell death [KO:K02158]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
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Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
fca00010  Glycolysis / Gluconeogenesis
fca04010  MAPK signaling pathway
fca04012  ErbB signaling pathway
fca04062  Chemokine signaling pathway
fca04064  NF-kappa B signaling pathway
fca04068  FoxO signaling pathway
fca04110  Cell cycle
fca04115  p53 signaling pathway
fca04150  mTOR signaling pathway
fca04210  Apoptosis
fca04370  VEGF signaling pathway
fca04510  Focal adhesion
fca04620  Toll-like receptor signaling pathway
fca04630  JAK-STAT signaling pathway
fca04662  B cell receptor signaling pathway
fca04910  Insulin signaling pathway
KO pathway
ko04151   

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