KEGG   PATHWAY: fca04010
Entry
fca04010                    Pathway                                
Name
MAPK signaling pathway - Felis catus (domestic cat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
fca04010  MAPK signaling pathway
fca04010

Other DBs
GO: 0000165
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100127108  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100135772  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
100135774  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
100136904  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
100141386  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100142682  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100142683  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100144611  NGF; beta-nerve growth factor [KO:K02582]
100379628  MYC; myc proto-oncogene protein [KO:K04377]
100499544  AKT2; RAC-beta serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
100500937  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100510799  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101080339  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101080463  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X3 [KO:K04458] [EC:3.1.3.48]
101080496  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101080578  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101080595  FGF21; fibroblast growth factor 21 [KO:K22429]
101080705  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101080710  [KO:K03283]
101080751  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101080870  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101080951  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101081041  AREG; amphiregulin isoform X1 [KO:K09782]
101081214  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X29 [KO:K04407] [EC:2.7.11.1]
101081315  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
101081387  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X3 [KO:K04368] [EC:2.7.12.2]
101081440  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
101081603  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101081668  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
101081819  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101081939  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101082033  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
101082196  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101082206  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101082274  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101082454  [KO:K04393]
101082505  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5 [KO:K04372] [EC:2.7.11.1]
101082546  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
101082574  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
101082582  STMN1; stathmin [KO:K04381]
101082637  FLNA; filamin-A isoform X1 [KO:K04437]
101082699  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X5 [KO:K04442] [EC:2.7.11.1]
101082828  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
101082829  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101082845  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101082912  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101082923  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
101083342  [KO:K16342] [EC:3.1.1.4]
101083468  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101083606  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101083633  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X2 [KO:K04421] [EC:2.7.11.25]
101083728  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
101083745  FGF22; fibroblast growth factor 22 [KO:K04358]
101083766  FGF20; fibroblast growth factor 20 [KO:K04358]
101084297  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101084335  FGF9; fibroblast growth factor 9 [KO:K04358]
101084346  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101084411  HSPB1; heat shock protein beta-1 [KO:K04455]
101084600  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101084652  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101084717  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
101084765  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101084778  FGF16; fibroblast growth factor 16 [KO:K04358]
101084908  CRKL; crk-like protein isoform X1 [KO:K04438]
101084919  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101084954  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X5 [KO:K08018]
101084984  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101085070  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
101085210  SRF; serum response factor [KO:K04378]
101085368  VEGFC; vascular endothelial growth factor C [KO:K05449]
101085388  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
101085456  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101085481  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101085733  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
101085762  RELB; transcription factor RelB isoform X3 [KO:K09253]
101085951  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101085955  PSPN; persephin [KO:K25416]
101086055  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101086100  CRK; adapter molecule crk isoform X1 [KO:K04438]
101086189  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101086432  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101086433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101086492  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
101086509  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101086544  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101086621  ELK4; ETS domain-containing protein Elk-4 isoform X2 [KO:K04376]
101086709  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101086776  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101086926  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101087092  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101087099  FGF19; fibroblast growth factor 19 [KO:K22603]
101087130  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101087164  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101087171  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101087206  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
101087287  PDGFA; platelet-derived growth factor subunit A isoform X4 [KO:K04359]
101087362  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
101087422  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101087614  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101087784  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
101087931  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101087958  MAPK3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
101087971  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101088292  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
101088394  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X8 [KO:K04851]
101088742  PDGFC; platelet-derived growth factor C [KO:K05450]
101088775  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
101088832  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101088847  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101088970  PRKCB; protein kinase C beta type isoform X3 [KO:K19662] [EC:2.7.11.13]
101089057  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X4 [KO:K04862]
101089265  DAXX; death domain-associated protein 6 [KO:K02308]
101089378  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101089557  MAPT; microtubule-associated protein tau isoform X15 [KO:K04380]
101089731  MAP3K10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101089813  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101089839  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
101090071  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101090260  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101090328  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
101090344  PPP3R1; calcineurin subunit B type 1 isoform X4 [KO:K06268]
101090489  FGF10; fibroblast growth factor 10 [KO:K04358]
101090494  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101090500  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101090606  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101090624  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101090684  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101090765  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101090833  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
101090884  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101091022  [KO:K03283]
101091172  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101091185  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101091274  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
101091310  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101091459  FGF6; fibroblast growth factor 6 [KO:K04358]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101091470  [KO:K04370]
101091536  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
101091635  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101091725  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
101091792  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101091977  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101092346  BRAF; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
101092407  NF1; neurofibromin isoform X1 [KO:K08052]
101092465  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101092716  TAOK1; serine/threonine-protein kinase TAO1 isoform X2 [KO:K04429] [EC:2.7.11.1]
101092757  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101092784  MRAS; ras-related protein M-Ras isoform X2 [KO:K07831]
101092818  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
101092941  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101093028  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X6 [KO:K04863]
101093052  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
101093097  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101093102  EREG; proepiregulin [KO:K09784]
101093110  RASGRP1; RAS guanyl-releasing protein 1 isoform X4 [KO:K04350]
101093205  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X3 [KO:K04422] [EC:2.7.11.25]
101093316  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101093414  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101093416  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101093558  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101093644  IGF2; insulin-like growth factor II isoform X3 [KO:K13769]
101093713  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
101093985  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X4 [KO:K04852]
101094038  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
101094057  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
101094125  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
101094163  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
101094170  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101094450  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
101094467  RASGRP4; RAS guanyl-releasing protein 4 isoform X4 [KO:K12363]
101094570  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
101094623  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
101094658  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2 [KO:K04860]
101094701  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
101094727  FLT4; vascular endothelial growth factor receptor 3 isoform X3 [KO:K05097] [EC:2.7.10.1]
101094770  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101094772  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101094822  EFNA3; ephrin-A3 [KO:K05462]
101094827  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7 [KO:K04344]
101094921  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101094942  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101095077  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101095132  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101095151  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
101095156  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
101095157  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101095179  RPS6KA5; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101095198  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101095353  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101095617  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101095834  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X5 [KO:K04861]
101095887  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X5 [KO:K04859]
101095899  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101095904  PGF; placenta growth factor isoform X8 [KO:K16859]
101095993  RAP1B; ras-related protein Rap-1b [KO:K07836]
101096047  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101096136  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101096187  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
101096363  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101096406  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
101096604  RELA; transcription factor p65 [KO:K04735]
101096697  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101096744  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101096794  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X2 [KO:K04444] [EC:2.7.11.1]
101097144  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101097255  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101097261  JUN; transcription factor AP-1 [KO:K04448]
101097357  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101097569  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
101097765  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101097773  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
101097871  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101097902  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101097977  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
101097982  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
101098110  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101098273  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
101098329  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101098469  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101098518  FGF18; fibroblast growth factor 18 [KO:K04358]
101098622  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101098654  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101098714  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101098757  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101098828  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101098862  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101099237  [KO:K03283]
101099264  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101099348  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
101099376  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
101099450  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101099466  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101099619  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
101099750  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101099916  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101100063  FGF23; fibroblast growth factor 23 [KO:K22428]
101100073  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
101100225  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101100281  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101100428  NTF4; neurotrophin-4 [KO:K12457]
101100725  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
101100864  FGFR4; fibroblast growth factor receptor 4 isoform X5 [KO:K05095] [EC:2.7.10.1]
101101078  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
101101086  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101101098  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
101101135  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101101237  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
101101259  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
101101277  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101101347  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
101101431  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
101101463  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101101519  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101101520  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101101571  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
101101576  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
101101624  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102899577  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102901787  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102902661  [KO:K04370]
105259780  JUND; transcription factor jun-D [KO:K04449]
105260573  [KO:K03283]
105260786  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
109493852  NRTN; neurturin [KO:K25414]
111556320  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111556546  FGF4; fibroblast growth factor 4 [KO:K04358]
111556666  FGF3; fibroblast growth factor 3 [KO:K04358]
111557556  EFNA2; ephrin-A2 isoform X2 [KO:K05462]
111561723  ARTN; artemin [KO:K25415]
493669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
493690  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
493703  VEGFD; vascular endothelial growth factor D [KO:K05449]
493705  HGF; hepatocyte growth factor precursor [KO:K05460]
493706  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493766  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
493796  FLT3LG; fms related tyrosine kinase 3 ligand precursor [KO:K05454]
493804  INS; insulin precursor [KO:K04526]
493845  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
493847  TP53; cellular tumor antigen p53 [KO:K04451]
493881  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
493932  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
493935  FOS; proto-oncogene c-Fos [KO:K04379]
493937  KITLG; kit ligand precursor [KO:K05461]
493944  IL1A; interleukin-1 alpha precursor [KO:K04383]
493945  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
493947  MAX; protein max [KO:K04453]
493957  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
493963  NTF3; neurotrophin-3 precursor [KO:K04356]
493978  EGF; pro-epidermal growth factor precursor [KO:K04357]
654399  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
751103  HRAS; GTPase HRas isoform X1 [KO:K02833]
751104  KRAS; GTPase KRas isoform X2 [KO:K07827]
751105  NRAS; GTPase NRas [KO:K07828]
751824  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
768263  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
768274  IL1B; interleukin-1 beta [KO:K04519]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
fca04070  Phosphatidylinositol signaling system
fca04110  Cell cycle
fca04115  p53 signaling pathway
fca04210  Apoptosis
fca04310  Wnt signaling pathway
fca04668  TNF signaling pathway
KO pathway
ko04010   

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