Homo sapiens (human): 3479
Help
Entry
3479 CDS
T01001
Symbol
IGF1, IGF, IGF-I, IGFI, MGF
Name
(RefSeq) insulin like growth factor 1
KO
K05459
insulin-like growth factor 1
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04114
Oocyte meiosis
hsa04115
p53 signaling pathway
hsa04150
mTOR signaling pathway
hsa04151
PI3K-Akt signaling pathway
hsa04152
AMPK signaling pathway
hsa04211
Longevity regulating pathway
hsa04213
Longevity regulating pathway - multiple species
hsa04510
Focal adhesion
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04730
Long-term depression
hsa04750
Inflammatory mediator regulation of TRP channels
hsa04913
Ovarian steroidogenesis
hsa04914
Progesterone-mediated oocyte maturation
hsa04935
Growth hormone synthesis, secretion and action
hsa04960
Aldosterone-regulated sodium reabsorption
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05205
Proteoglycans in cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05224
Breast cancer
hsa05410
Hypertrophic cardiomyopathy
hsa05414
Dilated cardiomyopathy
Network
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06210
ERK signaling (cancer)
nt06214
PI3K signaling (cancer)
nt06240
Transcription (cancer)
nt06263
Hepatocellular carcinoma
nt06324
GHRH-GH-IGF signaling
nt06526
MAPK signaling
nt06530
PI3K signaling
Element
N00133
EWSR1-FLI1 fusion to transcriptional activation
N00135
EWSR1-ERG fusion to transcriptional activation
N00182
IGF-IGFR-PI3K-NFKB signaling pathway
N00233
IGF-IGF1R-RAS-ERK signaling pathway
N00582
IGF-IGF1R-PI3K signaling pathway
N00907
GH-Jak-STAT signaling pathway
N01592
GF-RTK-RAS-ERK signaling pathway
N01656
GF-RTK-PI3K signaling pathway
N01658
GF-RTK-RAS-PI3K signaling pathway
Disease
H00015
Malignant pleural mesothelioma
H02040
Insulin-like growth factor I deficiency
Drug target
Masoprocol:
D04862
Toremifene (
DG00735
):
D00967
<JP/US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3479 (IGF1)
04014 Ras signaling pathway
3479 (IGF1)
04015 Rap1 signaling pathway
3479 (IGF1)
04066 HIF-1 signaling pathway
3479 (IGF1)
04068 FoxO signaling pathway
3479 (IGF1)
04151 PI3K-Akt signaling pathway
3479 (IGF1)
04152 AMPK signaling pathway
3479 (IGF1)
04150 mTOR signaling pathway
3479 (IGF1)
09140 Cellular Processes
09143 Cell growth and death
04114 Oocyte meiosis
3479 (IGF1)
04115 p53 signaling pathway
3479 (IGF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
3479 (IGF1)
04550 Signaling pathways regulating pluripotency of stem cells
3479 (IGF1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
3479 (IGF1)
04914 Progesterone-mediated oocyte maturation
3479 (IGF1)
04935 Growth hormone synthesis, secretion and action
3479 (IGF1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
3479 (IGF1)
09156 Nervous system
04730 Long-term depression
3479 (IGF1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
3479 (IGF1)
09149 Aging
04211 Longevity regulating pathway
3479 (IGF1)
04213 Longevity regulating pathway - multiple species
3479 (IGF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3479 (IGF1)
05202 Transcriptional misregulation in cancer
3479 (IGF1)
05205 Proteoglycans in cancer
3479 (IGF1)
09162 Cancer: specific types
05214 Glioma
3479 (IGF1)
05218 Melanoma
3479 (IGF1)
05215 Prostate cancer
3479 (IGF1)
05224 Breast cancer
3479 (IGF1)
09166 Cardiovascular disease
05410 Hypertrophic cardiomyopathy
3479 (IGF1)
05414 Dilated cardiomyopathy
3479 (IGF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
3479 (IGF1)
01522 Endocrine resistance
3479 (IGF1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
3479 (IGF1)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Growth factors (RTK binding)
3479 (IGF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Insulin
DUF2865
Motif
Other DBs
NCBI-GeneID:
3479
NCBI-ProteinID:
NP_001104755
OMIM:
147440
HGNC:
5464
Ensembl:
ENSG00000017427
CPD:
C16131
UniProt:
P05019
Structure
PDB
LinkDB
All DBs
Position
12:complement(102395874..102481839)
Genome browser
AA seq
195 aa
AA seq
DB search
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVD
ALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARS
VRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRR
EIGSRNAECRGKKGK
NT seq
588 nt
NT seq
+upstream
nt +downstream
nt
atgggaaaaatcagcagtcttccaacccaattatttaagtgctgcttttgtgatttcttg
aaggtgaagatgcacaccatgtcctcctcgcatctcttctacctggcgctgtgcctgctc
accttcaccagctctgccacggctggaccggagacgctctgcggggctgagctggtggat
gctcttcagttcgtgtgtggagacaggggcttttatttcaacaagcccacagggtatggc
tccagcagtcggagggcgcctcagacaggcatcgtggatgagtgctgcttccggagctgt
gatctaaggaggctggagatgtattgcgcacccctcaagcctgccaagtcagctcgctct
gtccgtgcccagcgccacaccgacatgcccaagacccagaagtatcagcccccatctacc
aacaagaacacgaagtctcagagaaggaaaggttggccaaagacacatccaggaggggaa
cagaaggaggggacagaagcaagtctgcagatcagaggaaagaagaaagagcagaggagg
gagattggaagtagaaatgctgaatgcagaggcaaaaaaggaaaatga
Homo sapiens (human): 4609
Help
Entry
4609 CDS
T01001
Symbol
MYC, MRTL, MYCC, bHLHe39, c-Myc
Name
(RefSeq) MYC proto-oncogene, bHLH transcription factor
KO
K04377
Myc proto-oncogene protein
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04110
Cell cycle
hsa04151
PI3K-Akt signaling pathway
hsa04218
Cellular senescence
hsa04310
Wnt signaling pathway
hsa04350
TGF-beta signaling pathway
hsa04390
Hippo signaling pathway
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04630
JAK-STAT signaling pathway
hsa04919
Thyroid hormone signaling pathway
hsa05132
Salmonella infection
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05163
Human cytomegalovirus infection
hsa05166
Human T-cell leukemia virus 1 infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05169
Epstein-Barr virus infection
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05210
Colorectal cancer
hsa05213
Endometrial cancer
hsa05216
Thyroid cancer
hsa05219
Bladder cancer
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06181
Salmonella
nt06210
ERK signaling (cancer)
nt06215
WNT signaling (cancer)
nt06227
Nuclear receptor signaling (cancer)
nt06230
Cell cycle (cancer)
nt06240
Transcription (cancer)
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06267
Small cell lung cancer
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06274
Thyroid cancer
nt06275
Acute myeloid leukemia
nt06505
WNT signaling
nt06526
MAPK signaling
Element
N00011
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00056
Wnt signaling pathway
N00057
Mutation-inactivated APC to Wnt signaling pathway
N00058
Mutation-activated CTNNB1 to Wnt signaling pathway
N00059
FZD7-overexpression to Wnt signaling pathway
N00060
LRP6-overexpression to Wnt signaling pathway
N00061
CDH1-reduced expression to beta-catenin signaling pathway
N00077
HRAS-overexpression to ERK signaling pathway
N00078
Mutation-activated HRAS to ERK signaling pathway
N00088
Amplified MYC to p15-cell cycle G1/S
N00089
Amplified MYC to cell cycle G1/S
N00090
p15-Cell cycle G1/S
N00092
Amplified MYC to p27-cell cycle G1/S
N00110
PLZF-RARA fusion to transcriptional activtion
N00133
EWSR1-FLI1 fusion to transcriptional activation
N00225
EBV EBNA2 to RBP-Jk-mediated transcription
N00242
Mutation-inactivated AXIN to Wnt signaling pathway
N00257
Loss of CDH1 to beta-catenin signaling pathway
N00258
Mutation-inactivated CDH1 to beta-catenin signaling pathway
N00287
ESR1-positive to nuclear-initiated estrogen signaling pathway
N00489
HTLV-1 p30II to c-myc-mediated transcription
N00512
HTLV-1 Tax to c-myc-mediated transcription
N00529
HCV core to RXRA/PPARA-mediated transcription
N00530
HCV core to RXRA/LXRA-mediated transcription
N01124
Salmonella AvrA to beta-catenin signaling pathway
N01344
NNK/NNN to RAS-ERK signaling pathway
N01602
ERK-MYC signaling pathway
Disease
H00001
B-cell acute lymphoblastic leukemia
H00002
T-cell acute lymphoblastic leukemia
H00008
Burkitt lymphoma
H00010
Multiple myeloma
H00013
Small cell lung cancer
H00016
Oral cancer
H00025
Penile cancer
H00027
Ovarian cancer
H00028
Choriocarcinoma
H00036
Osteosarcoma
H00041
Kaposi sarcoma
H00048
Hepatocellular carcinoma
H00055
Laryngeal cancer
H01463
Mycosis fungoides
H01509
Tonsillar cancer
H01554
Fallopian tube cancer
H01667
Medulloblastoma
H02434
Diffuse large B-cell lymphoma, not otherwise specified
Drug target
Omacetaxine mepesuccinate:
D08956
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
4609 (MYC)
04012 ErbB signaling pathway
4609 (MYC)
04310 Wnt signaling pathway
4609 (MYC)
04350 TGF-beta signaling pathway
4609 (MYC)
04390 Hippo signaling pathway
4609 (MYC)
04630 JAK-STAT signaling pathway
4609 (MYC)
04151 PI3K-Akt signaling pathway
4609 (MYC)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
4609 (MYC)
04218 Cellular senescence
4609 (MYC)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
4609 (MYC)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
4609 (MYC)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
4609 (MYC)
05202 Transcriptional misregulation in cancer
4609 (MYC)
05206 MicroRNAs in cancer
4609 (MYC)
05205 Proteoglycans in cancer
4609 (MYC)
05207 Chemical carcinogenesis - receptor activation
4609 (MYC)
05230 Central carbon metabolism in cancer
4609 (MYC)
09162 Cancer: specific types
05210 Colorectal cancer
4609 (MYC)
05225 Hepatocellular carcinoma
4609 (MYC)
05226 Gastric cancer
4609 (MYC)
05216 Thyroid cancer
4609 (MYC)
05221 Acute myeloid leukemia
4609 (MYC)
05220 Chronic myeloid leukemia
4609 (MYC)
05219 Bladder cancer
4609 (MYC)
05213 Endometrial cancer
4609 (MYC)
05224 Breast cancer
4609 (MYC)
05222 Small cell lung cancer
4609 (MYC)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
4609 (MYC)
05161 Hepatitis B
4609 (MYC)
05160 Hepatitis C
4609 (MYC)
05163 Human cytomegalovirus infection
4609 (MYC)
05167 Kaposi sarcoma-associated herpesvirus infection
4609 (MYC)
05169 Epstein-Barr virus infection
4609 (MYC)
09171 Infectious disease: bacterial
05132 Salmonella infection
4609 (MYC)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
4609 (MYC)
03019 Messenger RNA biogenesis [BR:
hsa03019
]
4609 (MYC)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Basic helix-loop-helix/leucine zipper (bHLH-ZIP)
Cell cycle controlling factors, Myc
4609 (MYC)
Messenger RNA biogenesis [BR:
hsa03019
]
Eukaryotic type
mRNA surveillance and transport factors
Factors involved in mRNA localization
Factors that have mRNA localization signals
4609 (MYC)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Myc_N
Myc-LZ
HLH
TRH
Motif
Other DBs
NCBI-GeneID:
4609
NCBI-ProteinID:
NP_002458
OMIM:
190080
HGNC:
7553
Ensembl:
ENSG00000136997
UniProt:
P01106
Structure
PDB
LinkDB
All DBs
Position
8:127735434..127742951
Genome browser
AA seq
454 aa
AA seq
DB search
MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP
SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTEL
LGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPA
RGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLS
STESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAG
GHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSP
RSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILS
VQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
NT seq
1365 nt
NT seq
+upstream
nt +downstream
nt
ctggatttttttcgggtagtggaaaaccagcagcctcccgcgacgatgcccctcaacgtt
agcttcaccaacaggaactatgacctcgactacgactcggtgcagccgtatttctactgc
gacgaggaggagaacttctaccagcagcagcagcagagcgagctgcagcccccggcgccc
agcgaggatatctggaagaaattcgagctgctgcccaccccgcccctgtcccctagccgc
cgctccgggctctgctcgccctcctacgttgcggtcacacccttctcccttcggggagac
aacgacggcggtggcgggagcttctccacggccgaccagctggagatggtgaccgagctg
ctgggaggagacatggtgaaccagagtttcatctgcgacccggacgacgagaccttcatc
aaaaacatcatcatccaggactgtatgtggagcggcttctcggccgccgccaagctcgtc
tcagagaagctggcctcctaccaggctgcgcgcaaagacagcggcagcccgaaccccgcc
cgcggccacagcgtctgctccacctccagcttgtacctgcaggatctgagcgccgccgcc
tcagagtgcatcgacccctcggtggtcttcccctaccctctcaacgacagcagctcgccc
aagtcctgcgcctcgcaagactccagcgccttctctccgtcctcggattctctgctctcc
tcgacggagtcctccccgcagggcagccccgagcccctggtgctccatgaggagacaccg
cccaccaccagcagcgactctgaggaggaacaagaagatgaggaagaaatcgatgttgtt
tctgtggaaaagaggcaggctcctggcaaaaggtcagagtctggatcaccttctgctgga
ggccacagcaaacctcctcacagcccactggtcctcaagaggtgccacgtctccacacat
cagcacaactacgcagcgcctccctccactcggaaggactatcctgctgccaagagggtc
aagttggacagtgtcagagtcctgagacagatcagcaacaaccgaaaatgcaccagcccc
aggtcctcggacaccgaggagaatgtcaagaggcgaacacacaacgtcttggagcgccag
aggaggaacgagctaaaacggagcttttttgccctgcgtgaccagatcccggagttggaa
aacaatgaaaaggcccccaaggtagttatccttaaaaaagccacagcatacatcctgtcc
gtccaagcagaggagcaaaagctcatttctgaagaggacttgttgcggaaacgacgagaa
cagttgaaacacaaacttgaacagctacggaactcttgtgcgtaa
Homo sapiens (human): 3398
Help
Entry
3398 CDS
T01001
Symbol
ID2, GIG8, ID2A, ID2H, bHLHb26
Name
(RefSeq) inhibitor of DNA binding 2
KO
K17693
DNA-binding protein inhibitor ID2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04350
TGF-beta signaling pathway
hsa04390
Hippo signaling pathway
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa05202
Transcriptional misregulation in cancer
Network
nt06240
Transcription (cancer)
Element
N00133
EWSR1-FLI1 fusion to transcriptional activation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04350 TGF-beta signaling pathway
3398 (ID2)
04390 Hippo signaling pathway
3398 (ID2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
3398 (ID2)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
3398 (ID2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
3398 (ID2)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Basic helix-loop-helix (bHLH)
HLH domain only
3398 (ID2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HLH
DUF6847
Motif
Other DBs
NCBI-GeneID:
3398
NCBI-ProteinID:
NP_002157
OMIM:
600386
HGNC:
5361
Ensembl:
ENSG00000115738
UniProt:
Q02363
Q53T66
Structure
PDB
LinkDB
All DBs
Position
2:8682056..8684461
Genome browser
AA seq
134 aa
AA seq
DB search
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVS
KMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEF
PSELMSNDSKALCG
NT seq
405 nt
NT seq
+upstream
nt +downstream
nt
atgaaagccttcagtcccgtgaggtccgttaggaaaaacagcctgtcggaccacagcctg
ggcatctcccggagcaaaacccctgtggacgacccgatgagcctgctatacaacatgaac
gactgctactccaagctcaaggagctggtgcccagcatcccccagaacaagaaggtgagc
aagatggaaatcctgcagcacgtcatcgactacatcttggacctgcagatcgccctggac
tcgcatcccactattgtcagcctgcatcaccagagacccgggcagaaccaggcgtccagg
acgccgctgaccaccctcaacacggatatcagcatcctgtccttgcaggcttctgaattc
ccttctgagttaatgtcaaatgacagcaaagcactgtgtggctga
DBGET
integrated database retrieval system