KEGG   PATHWAY: iti04530
Entry
iti04530                    Pathway                                
Name
Tight junction - Ictidomys tridecemlineatus (thirteen-lined ground squirrel)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
iti04530  Tight junction
iti04530

Other DBs
GO: 0005923
Organism
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) [GN:iti]
Gene
101954382  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
101954496  [KO:K05692]
101954526  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X7 [KO:K13305] [EC:2.3.2.26]
101954589  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
101954660  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
101954720  Igsf5; immunoglobulin superfamily member 5 [KO:K06786]
101954731  Jun; transcription factor AP-1 [KO:K04448]
101955056  Whamm; LOW QUALITY PROTEIN: WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
101955365  Actr2; actin-related protein 2 isoform X2 [KO:K17260]
101955375  Runx1; runt-related transcription factor 1 [KO:K08367]
101955555  Actn4; alpha-actinin-4 isoform X3 [KO:K05699]
101955760  Cldn20; claudin-20 [KO:K06087]
101955820  Rab8b; ras-related protein Rab-8B [KO:K07902]
101956646  Pals1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
101956898  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X14 [KO:K04851]
101956976  Cldn12; claudin-12 [KO:K06087]
101957002  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
101957062  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101957121  F11r; junctional adhesion molecule A [KO:K06089]
101957141  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
101957205  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101957234  Arhgap17; rho GTPase-activating protein 17 isoform X7 [KO:K20638]
101957248  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
101957477  Cldn6; claudin-6 [KO:K06087]
101957494  Ocln; occludin [KO:K06088]
101957541  Epb41l4b; band 4.1-like protein 4B [KO:K21111]
101957769  Cldn9; claudin-9 [KO:K06087]
101957784  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101957785  Marveld2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
101957941  Actr3; actin-related protein 3 [KO:K18584]
101958032  Myl6b; myosin light chain 6B [KO:K12751]
101958043  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101958222  Cldn25; putative claudin-25 [KO:K06087]
101958323  Jam2; junctional adhesion molecule B [KO:K06735]
101958324  Myl6; myosin light polypeptide 6 isoform X3 [KO:K12751]
101958360  Arpc1b; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
101958365  Pcna; proliferating cell nuclear antigen [KO:K04802]
101958383  [KO:K06099]
101958546  Ppp2cb; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101958598  Cldn5; claudin-5 [KO:K06087]
101958638  Actb; actin, cytoplasmic 1 [KO:K05692]
101958696  Actg1; actin, cytoplasmic 2 [KO:K05692]
101958725  Cd1e; T-cell surface glycoprotein CD1e, membrane-associated [KO:K06448]
101958865  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X2 [KO:K07200]
101958916  Tuba8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101959005  [KO:K06448]
101959100  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
101959358  [KO:K04513]
101959472  Rap2c; ras-related protein Rap-2c [KO:K07839]
101959670  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101959870  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
101959917  Mpdz; multiple PDZ domain protein isoform X8 [KO:K06095]
101959966  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
101960007  Actr3b; actin-related protein 3B [KO:K18584]
101960012  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101960106  Cldn15; claudin-15 [KO:K06087]
101960338  Mpp4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
101960522  [KO:K06274]
101960769  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101960860  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
101960990  Cttn; src substrate cortactin isoform X1 [KO:K06106]
101960992  [KO:K05755]
101961381  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101961432  Synpo; synaptopodin isoform X1 [KO:K21112]
101961580  Scrib; protein scribble homolog [KO:K16175]
101961819  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
101961864  Gata4; transcription factor GATA-4 [KO:K09183]
101961970  [KO:K06448]
101961973  Ezr; ezrin [KO:K08007]
101962014  Src; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101962500  Cldn11; claudin-11 [KO:K06087]
101962702  [KO:K07839]
101962705  [KO:K05631]
101962827  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101962829  [KO:K06448]
101963108  [KO:K06448]
101963153  Cgn; cingulin isoform X2 [KO:K06102]
101963226  [KO:K06448]
101963227  Myh11; myosin-11 isoform X1 [KO:K10352]
101963269  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101963371  Mapk8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
101963390  [KO:K06448]
101963429  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101963438  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101963776  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101963830  Arhgef18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
101964256  [KO:K06448]
101964354  Dlg3; disks large homolog 3 isoform X4 [KO:K21098]
101964526  [KO:K06448]
101964941  Cldn2; claudin-2 [KO:K06087]
101965258  Cldn1; claudin-1 [KO:K06087]
101965379  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101965411  [KO:K06448]
101965603  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101965699  [KO:K06448]
101965744  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
101966144  [KO:K04393]
101966292  [KO:K06448]
101966426  Rhoa; transforming protein RhoA [KO:K04513]
101966541  Cldn16; claudin-16 [KO:K06087]
101966583  [KO:K06448]
101966625  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101966654  Myl12b; myosin regulatory light chain 12B [KO:K12757]
101966752  Nf2; merlin isoform X1 [KO:K16684]
101966876  Erbb2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101966934  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101966943  [KO:K12757]
101967027  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101967050  [KO:K07199]
101967139  Was; wiskott-Aldrich syndrome protein [KO:K05747]
101967155  [KO:K06448]
101967289  Cldn18; claudin-18 isoform X2 [KO:K06087]
101967359  Dlg1; disks large homolog 1 isoform X4 [KO:K12076]
101967689  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101967780  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
101968177  Amotl1; angiomotin-like protein 1 isoform X1 [KO:K06104]
101968254  [KO:K07374]
101968553  Myh10; myosin-10 isoform X6 [KO:K10352]
101968902  Cldn8; claudin-8 [KO:K06087]
101968931  Pard3; partitioning defective 3 homolog isoform X2 [KO:K04237]
101968948  Hspa4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101969192  Cldn17; claudin-17 [KO:K06087]
101969334  Cgnl1; cingulin-like protein 1 isoform X2 [KO:K21110]
101969409  Tjp3; tight junction protein ZO-3 [KO:K06097]
101969560  Afdn; afadin isoform X13 [KO:K05702]
101969889  Tuba4a; tubulin alpha-4A chain [KO:K07374]
101969946  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
101970067  Cldn3; claudin-3 [KO:K06087]
101970177  [KO:K07374]
101970359  Cldn4; claudin-4 [KO:K06087]
101970380  Cldn7; claudin-7 [KO:K06087]
101970384  Rdx; radixin [KO:K05762]
101970797  Micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
101970921  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X5 [KO:K07200]
101971159  [KO:K04513]
101971563  Prkcz; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101971730  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X2 [KO:K04431] [EC:2.7.12.2]
101972024  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101972201  [KO:K06099]
101972315  Llgl2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
101972563  Dlg2; disks large homolog 2 isoform X10 [KO:K12075]
101972627  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X4 [KO:K06094]
101972766  [KO:K07374]
101972773  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.39]
101972863  Amotl2; angiomotin-like protein 2 [KO:K06104]
101972990  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101973055  [KO:K07374]
101973150  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
101973320  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
101973343  [KO:K07374]
101973372  Msn; moesin [KO:K05763]
101973749  Cldn34; claudin-34 [KO:K06087]
101973767  [KO:K06274]
101973809  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
101973868  Cldn19; claudin-19 isoform X2 [KO:K06087]
101973983  [KO:K07199]
101974548  Tjp2; tight junction protein ZO-2 [KO:K06098]
101975061  [KO:K07374]
101975090  [KO:K04354]
101975458  [KO:K06448]
101975523  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101975616  Stk11; serine/threonine-protein kinase STK11 isoform X5 [KO:K07298] [EC:2.7.11.1]
101975700  [KO:K06099]
101975739  Cd1c; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1c [KO:K06448]
101975800  Rab8a; ras-related protein Rab-8A [KO:K07901]
101975892  Bves; blood vessel epicardial substance isoform X3 [KO:K21108]
101975982  [KO:K06099]
101976436  [KO:K06099]
101976441  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
101976523  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101976557  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101976882  Myh14; myosin-14 [KO:K10352]
101977225  Sympk; symplekin isoform X1 [KO:K06100]
101977369  Amot; angiomotin isoform X1 [KO:K16819]
101977406  Cldn10; claudin-10 isoform X1 [KO:K06087]
101977601  Jam3; junctional adhesion molecule C [KO:K06785]
101977729  Cldn14; claudin-14 [KO:K06087]
101977768  Cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101977927  [KO:K06087]
101978071  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
101978125  Arhgef2; rho guanine nucleotide exchange factor 2 [KO:K12791]
101978211  [KO:K06087]
101978407  Rab13; ras-related protein Rab-13 [KO:K06109]
101978455  Tjp1; tight junction protein ZO-1 isoform X1 [KO:K05701]
101978495  Patj; inaD-like protein [KO:K06092]
101978523  Pard6g; partitioning defective 6 homolog gamma isoform X2 [KO:K06093]
101978549  Mapk9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101978565  Myh9; myosin-9 isoform X3 [KO:K10352]
101978600  Cldn23; claudin-23 [KO:K06087]
110599557  [KO:K06448]
120887441  [KO:K07374]
120889971  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
120890347  [KO:K06087]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
iti04520  Adherens junction
iti04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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