Entry Name IL-17 signaling pathway
Description The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. IL-17C has biological functions similar to those of IL-17A. The functions of IL-17B and IL-17D remain largely elusive. The IL-17 family signals via their correspondent receptors and activates downstream pathways that include NF-kappaB, MAPKs and C/EBPs to induce the expression of antimicrobial peptides, cytokines and chemokines. The receptor proximal adaptor Act1 (an NF-kappaB activator 1) is considered as the master mediator in IL-17A signaling. It is likely that Act1 is a common signal adaptor also shared by other members mediated signalings in this family.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Orthology K05164 interleukin 17 receptor A
K05165 interleukin 17 receptor B
K03171 tumor necrosis factor receptor type 1-associated DEATH domain protein
K02373 FAS-associated death domain protein
K02580 nuclear factor NF-kappa-B p105 subunit
K04735 transcription factor p65
K04379 proto-oncogene protein c-fos
K04448 transcription factor AP-1
K04449 transcription factor jun-D
K05166 interleukin 17 receptor C
K03174 TNF receptor-associated factor 3
K03352 anaphase-promoting complex subunit 5
K04079 molecular chaperone HtpG
K09487 heat shock protein 90kDa beta
K07210 inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467 inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K07209 inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K04734 NF-kappa-B inhibitor alpha
K04440 mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K10048 CCAAT/enhancer binding protein (C/EBP), beta
K09848 TNF receptor-associated factor 4
K07211 inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K09849 TNF receptor-associated factor 5
K12890 serine/arginine-rich splicing factor 1
K05505 C-X-C motif chemokine 1/2/3
K05506 C-X-C motif chemokine 5/6
K12671 C-X-C motif chemokine 10
K03156 tumor necrosis factor superfamily, member 2
K05423 granulocyte colony-stimulating factor
K05427 granulocyte-macrophage colony-stimulating factor
K01388 matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7 ]
K01394 matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17 ]
K07994 matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]
K05168 interleukin 17 receptor E
Reference Authors Song X, Qian Y
Title IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases.
Journal Reference Authors Song X, Qian Y
Title The activation and regulation of IL-17 receptor mediated signaling.
Journal Reference Authors Gu C, Wu L, Li X
Title IL-17 family: cytokines, receptors and signaling.
Journal Reference Authors Gaffen SL, Jain R, Garg AV, Cua DJ
Title The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.
Journal Reference Authors Iwakura Y, Ishigame H, Saijo S, Nakae S
Title Functional specialization of interleukin-17 family members.
Journal Reference Authors Qian Y, Kang Z, Liu C, Li X
Title IL-17 signaling in host defense and inflammatory diseases.
Journal Reference Authors Zhu S, Qian Y
Title IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential.
Journal Reference Authors Zenobia C, Hajishengallis G
Title Basic biology and role of interleukin-17 in immunity and inflammation.
Journal Reference Authors Reynolds JM, Angkasekwinai P, Dong C
Title IL-17 family member cytokines: regulation and function in innate immunity.
Journal Reference Authors Gaffen SL
Title Recent advances in the IL-17 cytokine family.
Journal Reference Authors Gaffen SL
Title An overview of IL-17 function and signaling.
Journal Reference Authors Hu Y, Shen F, Crellin NK, Ouyang W
Title The IL-17 pathway as a major therapeutic target in autoimmune diseases.
Journal Reference Authors Xu S, Cao X
Title Interleukin-17 and its expanding biological functions.
Journal Reference Authors Pappu R, Ramirez-Carrozzi V, Ota N, Ouyang W, Hu Y
Title The IL-17 family cytokines in immunity and disease.
Journal Reference Authors Gaffen SL
Title Structure and signalling in the IL-17 receptor family.
Journal Reference Authors Shen F, Gaffen SL
Title Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.
Journal Reference Authors Doyle MS, Collins ES, FitzGerald OM, Pennington SR
Title New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis.
Journal Reference Authors Gaffen SL, Kramer JM, Yu JJ, Shen F
Title The IL-17 cytokine family.
Journal Reference Authors Chang SH, Dong C
Title Signaling of interleukin-17 family cytokines in immunity and inflammation.
Journal Reference Authors Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B
Title IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.
Journal Reference Authors Qu F, Gao H, Zhu S, Shi P, Zhang Y, Liu Y, Jallal B, Yao Y, Shi Y, Qian Y
Title TRAF6-dependent Act1 phosphorylation by the IkappaB kinase-related kinases suppresses interleukin-17-induced NF-kappaB activation.
Journal Reference Authors Sharkhuu T, Matthaei KI, Forbes E, Mahalingam S, Hogan SP, Hansbro PM, Foster PS
Title Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity.
Journal Related ko04060 Cytokine-cytokine receptor interaction
ko04064 NF-kappa B signaling pathway
LinkDB All DBs
