KEGG   PATHWAY: lcat04518
Entry
lcat04518                   Pathway                                
Name
Integrin signaling - Lemur catta (Ring-tailed lemur)
Description
Integrins act as the primary transmembrane receptors for cell adhesion, enabling cells to interact with the extracellular matrix (ECM) or counter-receptors on other cells. Through these connections, integrins help control essential cellular functions, including movement, polarity, proliferation, and viability. Ligand binding triggers integrin clustering and recruits actin filaments and various signaling proteins to their cytoplasmic domains, thereby activating downstream pathways.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
lcat04518  Integrin signaling
lcat04518

Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620286  VTN; vitronectin [KO:K06251]
123620468  CHAD; chondroadherin [KO:K06248]
123620522  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
123620572  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
123620638  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
123620722  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123620728  ITGA3; integrin alpha-3 [KO:K06482]
123620839  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123621031  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
123621656  [KO:K06240]
123621678  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123621697  LAMA1; laminin subunit alpha-1 [KO:K05637]
123621930  THBS1; thrombospondin-1 [KO:K16857]
123622345  FBN1; fibrillin-1 [KO:K06825]
123622361  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
123622511  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
123622760  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123622912  FERMT1; fermitin family homolog 1 isoform X1 [KO:K17082]
123623287  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
123623521  CTNNB1; catenin beta-1 [KO:K02105]
123623582  FLNB; filamin-B isoform X1 [KO:K27392]
123624079  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123624368  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123625167  CDH1; cadherin-1 [KO:K05689]
123625492  ITGA8; integrin alpha-8 [KO:K06584]
123625938  PXN; paxillin isoform X1 [KO:K05760]
123626683  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123626869  LAMC2; laminin subunit gamma-2 [KO:K06246]
123626918  LAMB3; laminin subunit beta-3 [KO:K06244]
123627028  LAMC1; laminin subunit gamma-1 [KO:K05635]
123627265  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
123627309  [KO:K23573]
123627310  DMP1; dentin matrix acidic phosphoprotein 1 isoform X1 [KO:K23328]
123627312  [KO:K06253]
123627314  SPP1; osteopontin [KO:K06250]
123627363  FRAS1; extracellular matrix organizing protein FRAS1 isoform X1 [KO:K23379]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627720  NPNT; nephronectin isoform X1 [KO:K06824]
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123628106  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123628143  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
123628302  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
123628484  FLNA; filamin-A isoform X1 [KO:K04437]
123628643  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
123628864  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
123629856  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123630278  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123630462  ITGB5; integrin beta-5 [KO:K06588]
123630505  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123630651  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
123630775  [KO:K06464]
123630818  ITGB2; integrin beta-2 [KO:K06464]
123630827  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
123630829  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
123631525  ACTB; actin, cytoplasmic 1 [KO:K05692]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631770  TNXB; tenascin-X [KO:K06252]
123631783  ITGA11; integrin alpha-11 [KO:K06587]
123631868  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123632034  [KO:K06462]
123632103  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
123632162  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
123632534  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123632683  [KO:K06594]
123632686  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
123632733  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
123633180  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123633252  LAMA2; laminin subunit alpha-2 [KO:K05637]
123633462  THBS2; thrombospondin-2 [KO:K04659]
123633876  ITGA10; integrin alpha-10 [KO:K06586]
123634060  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
123634153  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
123634163  ICAM4; intercellular adhesion molecule 4 isoform X1 [KO:K06581]
123634187  [KO:K02649]
123634195  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
123634479  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123634506  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
123634827  TNN; tenascin-N [KO:K06252]
123635275  TNR; tenascin-R isoform X1 [KO:K06252]
123635347  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
123635697  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123635930  C3; complement C3 [KO:K03990]
123637289  NCK2; cytoplasmic protein NCK2 [KO:K19862]
123637296  LIMS1; LIM and senescent cell antigen-like-containing domain protein 1 isoform X1 [KO:K23354]
123638073  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123638505  FGB; fibrinogen beta chain [KO:K03904]
123638506  FGA; fibrinogen alpha chain [KO:K03903]
123638507  FGG; fibrinogen gamma chain [KO:K03905]
123638516  PDGFC; platelet-derived growth factor C [KO:K05450]
123638557  [KO:K04659]
123638671  VEGFC; vascular endothelial growth factor C [KO:K05449]
123639233  PARVG; gamma-parvin isoform X1 [KO:K06275]
123639234  PARVB; beta-parvin isoform X1 [KO:K06275]
123639237  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123639294  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123639374  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123639684  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123639686  ITGA5; integrin alpha-5 [KO:K06484]
123639706  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123639774  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
123640137  VWF; von Willebrand factor [KO:K03900]
123640152  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123640465  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
123641432  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123641437  FERMT3; fermitin family homolog 3 isoform X1 [KO:K17084]
123641878  PDGFD; platelet-derived growth factor D [KO:K05450]
123642363  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
123642456  PARVA; alpha-parvin isoform X1 [KO:K06275]
123642799  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
123643240  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
123643361  LIMS2; LIM and senescent cell antigen-like-containing domain protein 2 isoform X1 [KO:K23354]
123643427  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123643670  ITGA4; integrin alpha-4 [KO:K06483]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123643847  [KO:K06238]
123643905  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123643937  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123643975  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123644039  FN1; fibronectin isoform X1 [KO:K05717]
123644098  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
123644099  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
123644599  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123645036  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123646154  TLN1; talin-1 isoform X1 [KO:K06271]
123646589  LAMC3; laminin subunit gamma-3 [KO:K06247]
123646604  PGF; placenta growth factor isoform X1 [KO:K16859]
123646646  TNC; tenascin isoform X1 [KO:K06252]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123647073  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
123647178  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123647251  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123647516  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
123647710  LAMB4; laminin subunit beta-4 [KO:K06245]
123647712  LAMB1; laminin subunit beta-1 [KO:K05636]
123648225  ITGA2; integrin alpha-2 [KO:K06481]
123648362  THBS4; thrombospondin-4 [KO:K04659]
123648578  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123648588  ITGA1; integrin alpha-1 [KO:K06480]
123648845  FREM2; FRAS1-related extracellular matrix protein 2 [KO:K23380]
123648918  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123649088  FERMT2; fermitin family homolog 2 isoform X1 [KO:K17083]
123649315  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
123649345  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123650282  VCL; vinculin isoform X1 [KO:K05700]
123650686  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123650723  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123650804  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
Reference
PMID:36588107
  Authors
Pang X, He X, Qiu Z, Zhang H, Xie R, Liu Z, Gu Y, Zhao N, Xiang Q, Cui Y
  Title
Targeting integrin pathways: mechanisms and advances in therapy.
  Journal
Signal Transduct Target Ther 8:1 (2023)
DOI:10.1038/s41392-022-01259-6
Reference
PMID:40001469
  Authors
Katoh K
  Title
Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction.
  Journal
Biomolecules 15:biom15020166 (2025)
DOI:10.3390/biom15020166
Reference
PMID:24467163
  Authors
Morse EM, Brahme NN, Calderwood DA
  Title
Integrin cytoplasmic tail interactions.
  Journal
Biochemistry 53:810-20 (2014)
DOI:10.1021/bi401596q
Reference
PMID:12743027
  Authors
Brakebusch C, Fassler R
  Title
The integrin-actin connection, an eternal love affair.
  Journal
EMBO J 22:2324-33 (2003)
DOI:10.1093/emboj/cdg245
Reference
PMID:40748480
  Authors
Ain U, Fatma B, Firdaus H
  Title
The ILK-PINCH-parvin complex: a conserved primary adhesome regulating biological processes.
  Journal
Histochem Cell Biol 163:78 (2025)
DOI:10.1007/s00418-025-02408-y
Reference
PMID:35804980
  Authors
McDonald PC, Dedhar S
  Title
New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis.
  Journal
Cancers (Basel) 14:cancers14133209 (2022)
DOI:10.3390/cancers14133209
Reference
PMID:24904821
  Authors
Shishido S, Bonig H, Kim YM
  Title
Role of integrin alpha4 in drug resistance of leukemia.
  Journal
Front Oncol 4:99 (2014)
DOI:10.3389/fonc.2014.00099
Related
pathway
lcat04010  MAPK signaling pathway
lcat04110  Cell cycle
lcat04150  mTOR signaling pathway
lcat04151  PI3K-Akt signaling pathway
lcat04310  Wnt signaling pathway
lcat04510  Focal adhesion
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko04518   

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