Entry Name Focal adhesion - Lemur catta (Ring-tailed lemur)
Description Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class Cellular Processes; Cellular community - eukaryotesBRITE hierarchy
Pathway map Other DBs Organism Lemur catta (Ring-tailed lemur) [GN:
lcat ]
Gene 123624687 PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457 ]
123625428 BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726 ]
123626055 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
123626957 PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329 ]
123628106 VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449 ]
123629856 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
123630278 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
123630827 COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238 ]
123630829 COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238 ]
123632534 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
123632745 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
123634506 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
123639237 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
123639294 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
123639486 PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270 ]
123639706 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
123641429 BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158 ]
123641432 VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858 ]
123644768 RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349 ]
123646573 RAPGEF1; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1 [KO:K06277 ]
123647604 MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754 ]
123648578 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
123650723 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
Compound C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Berman AE, Kozlova NI, Morozevich GE.
Title Integrins: structure and signaling.
Journal Reference Authors Lee JW, Juliano R.
Title Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
Journal Mol Cells 17:188-202 (2004)
Reference Authors Danen EH, Yamada KM.
Title Fibronectin, integrins, and growth control.
Journal Reference Authors Guo W, Giancotti FG.
Title Integrin signalling during tumour progression.
Journal Reference Authors Petit V, Thiery JP.
Title Focal adhesions: structure and dynamics.
Journal Reference Authors Stupack DG, Cheresh DA.
Title Get a ligand, get a life: integrins, signaling and cell survival.
Journal Reference Authors Parsons JT.
Title Focal adhesion kinase: the first ten years.
Journal Reference Authors Mitra SK, Hanson DA, Schlaepfer DD.
Title Focal adhesion kinase: in command and control of cell motility.
Journal Reference Authors Comoglio PM, Boccaccio C, Trusolino L.
Title Interactions between growth factor receptors and adhesion molecules: breaking the rules.
Journal Reference Authors Schlaepfer DD, Mitra SK.
Title Multiple connections link FAK to cell motility and invasion.
Journal Reference Authors Burridge K, Wennerberg K.
Title Rho and Rac take center stage.
Journal Reference Authors Schmitz AA, Govek EE, Bottner B, Van Aelst L.
Title Rho GTPases: signaling, migration, and invasion.
Journal Reference Authors Vanhaesebroeck B, Alessi DR.
Title The PI3K-PDK1 connection: more than just a road to PKB.
Journal Reference Authors Nicholson KM, Anderson NG.
Title The protein kinase B/Akt signalling pathway in human malignancy.
Journal Reference Authors Oloumi A, McPhee T, Dedhar S.
Title Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
Journal Reference Authors Turner CE.
Title Paxillin and focal adhesion signalling.
Journal Reference Authors Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
Title The mechanism of action of the tumour suppressor gene PTEN.
Journal Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related lcat04060 Cytokine-cytokine receptor interaction
lcat04070 Phosphatidylinositol signaling system
KO pathway
